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Therapeutic Effects Of Prolonged Cannabidiol Treatment On Psychological Symptoms And Cognitive Function In Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial, Nadia Solowij, Samantha J. Broyd, Camilla Beale, Julie-Anne Prick, Lisa-Marie Greenwood, Hendrika H. Van Hell, Chao Suo, Peter Galettis, Nagesh B. Pai, Shanlin Fu, Rodney J. Croft, Jennifer H. Martin, Murat Yucel
Therapeutic Effects Of Prolonged Cannabidiol Treatment On Psychological Symptoms And Cognitive Function In Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial, Nadia Solowij, Samantha J. Broyd, Camilla Beale, Julie-Anne Prick, Lisa-Marie Greenwood, Hendrika H. Van Hell, Chao Suo, Peter Galettis, Nagesh B. Pai, Shanlin Fu, Rodney J. Croft, Jennifer H. Martin, Murat Yucel
Faculty of Social Sciences - Papers (Archive)
Chronic cannabis use has been associated with impaired cognition and elevated psychological symptoms, particularly psychotic-like experiences.
Prolonged Cannabidiol Treatment Effects On Hippocampal Subfield Volumes In Current Cannabis Users, Camilla Beale, Samantha J. Broyd, Yann Chye, Mark M. Schira, Peter Galettis, Jennifer H. Martin, Murat Yucel, Nadia Solowij
Prolonged Cannabidiol Treatment Effects On Hippocampal Subfield Volumes In Current Cannabis Users, Camilla Beale, Samantha J. Broyd, Yann Chye, Mark M. Schira, Peter Galettis, Jennifer H. Martin, Murat Yucel, Nadia Solowij
Faculty of Social Sciences - Papers (Archive)
No abstract provided.
Effect Of Cannabis Use In People With Chronic Non-Cancer Pain Prescribed Opioids: Findings From A 4-Year Prospective Cohort Study, Gabrielle Campbell, Wayne Hall, Amy Peacock, Nicholas Lintzeris, Raimondo Bruno, Briony K. Larance, Suzanne Nielsen, Milton Cohen, Gary Chan, Richard P. Mattick, Fiona Blyth, Marian D. Shanahan, Timothy Dobbins, Michael P. Farrell, Louisa Degenhardt
Effect Of Cannabis Use In People With Chronic Non-Cancer Pain Prescribed Opioids: Findings From A 4-Year Prospective Cohort Study, Gabrielle Campbell, Wayne Hall, Amy Peacock, Nicholas Lintzeris, Raimondo Bruno, Briony K. Larance, Suzanne Nielsen, Milton Cohen, Gary Chan, Richard P. Mattick, Fiona Blyth, Marian D. Shanahan, Timothy Dobbins, Michael P. Farrell, Louisa Degenhardt
Faculty of Social Sciences - Papers (Archive)
Background Interest in the use of cannabis and cannabinoids to treat chronic non-cancer pain is increasing, because of their potential to reduce opioid dose requirements. We aimed to investigate cannabis use in people living with chronic non-cancer pain who had been prescribed opioids, including their reasons for use and perceived effectiveness of cannabis; associations between amount of cannabis use and pain, mental health, and opioid use; the effect of cannabis use on pain severity and interference over time; and potential opioid-sparing effects of cannabis. Methods The Pain and Opioids IN Treatment study is a prospective, national, observational cohort of people …
The Neurobiology Of Cannabis Use Disorders: A Call For Evidence, Valentina Lorenzetti, Janna Cousijn, Nadia Solowij, Hugh Garavan, C Suo, Murat Yucel, Antonio Verdejo-Garcia
The Neurobiology Of Cannabis Use Disorders: A Call For Evidence, Valentina Lorenzetti, Janna Cousijn, Nadia Solowij, Hugh Garavan, C Suo, Murat Yucel, Antonio Verdejo-Garcia
Faculty of Social Sciences - Papers (Archive)
Using cannabis is perceived by many as relatively harmless, but the adverse effects of problematic cannabis use are significant.
Clinical Trials Of Medicinal Cannabis For Appetite-Related Symptoms From Advanced Cancer: A Survey Of Preferences, Attitudes And Beliefs Among Patients Willing To Consider Participation, Tim Luckett, Jane Phillips, Nicholas Lintzeris, David J. Allsop, J Lee, Nadia Solowij, Jennifer H. Martin, L Lam, R Aggarwal, Nikki Mccaffrey, David C. Currow, R Chye, Melanie Lovell, Iain Prof Iain Mcgregor, Meera Agar
Clinical Trials Of Medicinal Cannabis For Appetite-Related Symptoms From Advanced Cancer: A Survey Of Preferences, Attitudes And Beliefs Among Patients Willing To Consider Participation, Tim Luckett, Jane Phillips, Nicholas Lintzeris, David J. Allsop, J Lee, Nadia Solowij, Jennifer H. Martin, L Lam, R Aggarwal, Nikki Mccaffrey, David C. Currow, R Chye, Melanie Lovell, Iain Prof Iain Mcgregor, Meera Agar
Faculty of Social Sciences - Papers (Archive)
Australian clinical trials are planned to evaluate medicinal cannabis in a range of clinical contexts. Aims: To explore the preferences, attitudes and beliefs of patients eligible and willing to consider participation in a clinical trial of medicinal cannabis for poor appetite and appetite-related symptoms from advanced cancer.
Mismatch Negativity And P50 Sensory Gating In Abstinent Former Cannabis Users, Samantha J. Broyd, Lisa-Marie Greenwood, Hendrika H. Van Hell, Rodney J. Croft, Hannah Coyle, Benjamin Lee-Bates, Juanita Todd, Stuart J. Johnstone, Patricia Michie, Nadia Solowij
Mismatch Negativity And P50 Sensory Gating In Abstinent Former Cannabis Users, Samantha J. Broyd, Lisa-Marie Greenwood, Hendrika H. Van Hell, Rodney J. Croft, Hannah Coyle, Benjamin Lee-Bates, Juanita Todd, Stuart J. Johnstone, Patricia Michie, Nadia Solowij
Faculty of Social Sciences - Papers (Archive)
Prolonged heavy exposure to cannabis is associated with impaired cognition and brain functional and structural alterations. We recently reported attenuated mismatch negativity (MMN) and altered P50 sensory gating in chronic cannabis users. This study investigated the extent of brain functional recovery (indexed by MMN and P50) in chronic users after cessation of use. Eighteen ex-users (median 13.5 years prior regular use; median 3.5 years abstinence) and 18 nonusers completed (1) a multifeature oddball task with duration, frequency, and intensity deviants and (2) a P50 paired-click paradigm. Trend level smaller duration MMN amplitude and larger P50 ratios (indicative of poorer sensory …
Hippocampal Harms, Protection And Recovery Following Regular Cannabis Use, Murat Yucel, Valentina Lorenzetti, C Suo, Andrew Zalesky, Alex Fornito, Michael J. Takagi, Daniel Lubman, Nadia Solowij
Hippocampal Harms, Protection And Recovery Following Regular Cannabis Use, Murat Yucel, Valentina Lorenzetti, C Suo, Andrew Zalesky, Alex Fornito, Michael J. Takagi, Daniel Lubman, Nadia Solowij
Faculty of Social Sciences - Papers (Archive)
Shifting policies towards legalisation of cannabis for therapeutic and recreational use raise significant ethical issues for health-care providers seeking evidence-based recommendations. We investigated whether heavy cannabis use is associated with persistent harms to the hippocampus, if exposure to cannabidiol offers protection, and whether recovery occurs with abstinence. To do this, we assessed 111 participants: 74 long-term regular cannabis users (with an average of 15.4 years of use) and 37 non-user healthy controls. Cannabis users included subgroups of participants who were either exposed to Δ9-tetrahydrocannabinol (THC) but not to cannabidiol (CBD) or exposed to both, and former users with sustained abstinence. …
The Role Of Cannabinoids In Neuroanatomic Alterations In Cannabis Users, Valentina Lorenzetti, Nadia Solowij, Murat Yuecel
The Role Of Cannabinoids In Neuroanatomic Alterations In Cannabis Users, Valentina Lorenzetti, Nadia Solowij, Murat Yuecel
Faculty of Social Sciences - Papers (Archive)
The past few decades have seen a marked change in the composition of commonly smoked cannabis. These changes primarily involve an increase of the psychoactive compound Delta(9)-tetrahydrocannabinol (THC) and a decrease of the potentially therapeutic compound cannabidiol (CBD). This altered composition of cannabis may be linked to persistent neuroanatomic alterations typically seen in regular cannabis users. In this review, we summarize recent findings from human structural neuroimaging investigations. We examine whether neuroanatomic alterations are 1) consistently observed in samples of regular cannabis users, particularly in cannabinoid receptor-high areas, which are vulnerable to the effects of high circulating levels of THC, …
Are Cannabis Expectancies Related To Subjective Drug Experiences And Schizotypy?, Emma Barkus, Tahlia Muddle, John Stirling, Shon Lewis
Are Cannabis Expectancies Related To Subjective Drug Experiences And Schizotypy?, Emma Barkus, Tahlia Muddle, John Stirling, Shon Lewis
Faculty of Social Sciences - Papers (Archive)
Objective: There is an established literature on cannabis expectancies and how these relate to patterns of cannabis use and clinical outcomes. However increasingly we are becoming interested in how cannabis expectancies shape the subjective experiences people have during drug use, and vice versa. Here we present data reporting how cannabis expectancies relate to subjective experiences after cannabis. Additionally we will determine whether an index of psychosis proneness (schizotypy) is related to cannabis expectancies. Method: A sample of recreational cannabis users (n=137) completed the brief Schizotypal Personality Questionnaire, the Cannabis Experiences Questionnaire and the Marijuana Effects Expectancy Questionnaire. Results: Cannabis expectancies …
Gross Morphological Brain Changes With Chronic, Heavy Cannabis Use, Valentina Lorenzetti, Nadia Solowij, Sarah Whittle, Alex Fornito, Daniel Lubman, Christos Pantelis, Murat Yücel
Gross Morphological Brain Changes With Chronic, Heavy Cannabis Use, Valentina Lorenzetti, Nadia Solowij, Sarah Whittle, Alex Fornito, Daniel Lubman, Christos Pantelis, Murat Yücel
Faculty of Social Sciences - Papers (Archive)
We investigated the morphology of multiple brain regions in a rare sample of 15 very heavy cannabis users with minimal psychiatric comorbidity or significant exposure to other substances (compared with 15 age- and IQ-matched non-cannabis-using controls) using manual techniques. Heavy cannabis users demonstrated smaller hippocampus and amygdala volumes, but no alterations of the orbitofrontal and anterior- and paracingulate cortices, or the pituitary gland. These findings indicate that chronic cannabis use has a selective and detrimental impact on the morphology of the mediotemporal lobe.
Smoking Mull: A Grounded Theory Model On The Dynamics Of Combined Tobacco And Cannabis Use Among Men, A Banbury, Avigdor Zask, Stacy M. Carter, Eric Van Beurden, R Tokley, Megan Passey, Jan Copeland
Smoking Mull: A Grounded Theory Model On The Dynamics Of Combined Tobacco And Cannabis Use Among Men, A Banbury, Avigdor Zask, Stacy M. Carter, Eric Van Beurden, R Tokley, Megan Passey, Jan Copeland
Faculty of Social Sciences - Papers (Archive)
Issue addressed Australians' use of cannabis has been increasing. Over a third of Australians (35.4%) have used cannabis at some time in their lives and 10.3% are recent users. Almost two‐thirds of cannabis users combine cannabis with tobacco. The aim of this study was to understand the process of mulling - smoking tobacco and cannabis together - using a grounded theory approach. Methods Twenty‐one in‐depth semistructured interviews were conducted with men aged 25-34 and living on the North Coast of New South Wales. Interviews explored participants' smoking practices, histories and cessation attempts. Results A model describing mulling behaviour and the …
An Investigation Of Mismatch Negativity In Current And Ex-Cannabis Users Using A Feature Controlled Method, Felicity Webster, Samantha Broyd, Lisa-Marie Greenwood, Rodney J. Croft, Juanita Todd, Patricia Michie, Stuart Johnstone, Benjamin Lee-Bates, Hannah Coyle, Nadia Solowij
An Investigation Of Mismatch Negativity In Current And Ex-Cannabis Users Using A Feature Controlled Method, Felicity Webster, Samantha Broyd, Lisa-Marie Greenwood, Rodney J. Croft, Juanita Todd, Patricia Michie, Stuart Johnstone, Benjamin Lee-Bates, Hannah Coyle, Nadia Solowij
Faculty of Social Sciences - Papers (Archive)
Abstract presented at the 23rd Australasian Society for Psychophysiology Conference, 20-22 Nov 2013, Wollongong, Australia
Chronic Effects Of Cannabis On Sensory Gating, Samantha J. Broyd, Lisa-Marie Greenwood, Rodney Croft, Anna Dalecki, Juanita Todd, Patricia T. Michie, Stuart J. Johnstone, Nadia Solowij
Chronic Effects Of Cannabis On Sensory Gating, Samantha J. Broyd, Lisa-Marie Greenwood, Rodney Croft, Anna Dalecki, Juanita Todd, Patricia T. Michie, Stuart J. Johnstone, Nadia Solowij
Faculty of Social Sciences - Papers (Archive)
Chronic cannabis use has been associated with neurocognitive deficits, alterations in brain structure and function, and with psychosis. This study investigated the effects of chronic cannabis use on P50 sensory-gating in regular users, and explored the association between sensory gating, cannabis use history and the development of psychotic-like symptoms. Twenty controls and 21 regular cannabis users completed a P50 paired-click (S1 and S2) paradigm with an inter-pair interval of 9. s. The groups were compared on P50 amplitude to S1 and S2, P50 ratio (S2/S1) and P50 difference score (S1-S2). While cannabis users overall did not differ from controls on …
Alteration To Hippocampal Shape In Cannabis Users With And Without Schizophrenia, Nadia Solowij, Mark Walterfang, Daniel I. Lubman, Sarah Whittle, Valentina Lorenzetti, Martin Styner, Dennis Velakoulis, Christos Pantelis, Murat Yuecel
Alteration To Hippocampal Shape In Cannabis Users With And Without Schizophrenia, Nadia Solowij, Mark Walterfang, Daniel I. Lubman, Sarah Whittle, Valentina Lorenzetti, Martin Styner, Dennis Velakoulis, Christos Pantelis, Murat Yuecel
Faculty of Social Sciences - Papers (Archive)
Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users. There is a paucity of research investigating potential additive effects of cannabis use on brain pathology associated with schizophrenia. In this study, we performed hippocampal shape analysis in cannabis-using and non-using patients with schizophrenia, healthy cannabis users and healthy non-using controls. Hippocampal shape changes were observed in each group relative to controls, with the greatest degree of alterations (i.e., deflations across the hippocampus, and with an anterior predisposition), in cannabis-using schizophrenia patients. These alterations were associated with cannabis use patterns and psychotic symptoms.
Familial Analysis Of Mmn In Cannabis Users: A Case Study, Felicity Webster, Samantha Broyd, Rodney J. Croft, Hendrika H. Van Hell, Lisa-Marie Greenwood, Stuart Johnstone, Juanita Todd, Patricia Michie, Nadia Solowij
Familial Analysis Of Mmn In Cannabis Users: A Case Study, Felicity Webster, Samantha Broyd, Rodney J. Croft, Hendrika H. Van Hell, Lisa-Marie Greenwood, Stuart Johnstone, Juanita Todd, Patricia Michie, Nadia Solowij
Faculty of Social Sciences - Papers (Archive)
Abstract presented at the 23rd Australasian Society for Psychophysiology Conference, 20-22 Nov 2013, Wollongong, Australia
The Effects Of Regular Long-Term Cannabis Use On Auditory Mismatch Negativity (Mmn), Lisa-Marie Greenwood, Samantha J. Broyd, Rodney J. Croft, Patricia T. Michie, Juanita Todd, Stuart J. Johnstone, Robyn Murray, Nadia Solowij
The Effects Of Regular Long-Term Cannabis Use On Auditory Mismatch Negativity (Mmn), Lisa-Marie Greenwood, Samantha J. Broyd, Rodney J. Croft, Patricia T. Michie, Juanita Todd, Stuart J. Johnstone, Robyn Murray, Nadia Solowij
Faculty of Social Sciences - Papers (Archive)
Abstract presented at the 3rd Biennial Schizophrenia International Research Conference Florence, Italy 14-18 April 2012
Does Cannabis Cause Lasting Brain Damage?, Nadia Solowij, Murat Yucel, Valentina Lorenzetti, Dan Lubman
Does Cannabis Cause Lasting Brain Damage?, Nadia Solowij, Murat Yucel, Valentina Lorenzetti, Dan Lubman
Faculty of Social Sciences - Papers (Archive)
Until recently, it was possible to state with some confi - dence that there was no evidence of cannabis-related brain damage in humans. There was some support from the animal literature, but few human studies had been conducted where the findings could not be explained by methodological or other confounding factors. Recent evidence for gross morphological, connectivity and microstructural changes has now emerged that warrants further consideration. If cannabis were found to alter the structural integrity of the brain, then this may assist us to understand the mechanisms by which cannabis triggers psychotic symptoms or overt psychosis in vulnerable individuals.
Visuospatial Memory Deficits In Long Term Heavy Cannabis Users: Relation To Psychotic Symptoms And Regional Brain Volumes, Nadia Solowij, Colleen Respondek, Robert A. Battisti, Sarah Whittle, Daniel Dr Daniel Lubman, Murat Yucel
Visuospatial Memory Deficits In Long Term Heavy Cannabis Users: Relation To Psychotic Symptoms And Regional Brain Volumes, Nadia Solowij, Colleen Respondek, Robert A. Battisti, Sarah Whittle, Daniel Dr Daniel Lubman, Murat Yucel
Faculty of Social Sciences - Papers (Archive)
Abstract from the XXVI CINP Congress, Munich, 13-17 July 2008
Cannabis And Cognitive Function: Relevant To Psychosis, Nadia Solowij
Cannabis And Cognitive Function: Relevant To Psychosis, Nadia Solowij
Faculty of Social Sciences - Papers (Archive)
Abstract from 'Brainwaves'- The Australasian Society for Psychiatric Research Annual Meeting 2006, 6-8 December, Sydney, Australia