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Diet And Sex Differences Induce Unique Alterations Of Markers For Blood Brain Barrier Integrity In Age-Accelerated Mice, Dakota R. Kamm, Kenneth A. Witt, Karin E. Sandoval, Megan L. Schaller, Matthew P. Harris, Joshua S. Wooten

International Journal of Exercise Science: Conference Proceedings

The role of diet on brain health has received significant attention, with the Western diet (WD) contributing to cerebrovascular alterations and neurodegenerative disease. The blood-brain barrier (BBB) may play a particularly important role as it forms the interface between the peripheral circulation and the central nervous system. The WD has been shown to negatively impact the BBB. Whether there are sex specific differences with diet on BBB integrity remains unclear. PURPOSE: To determine the effect of diet and sex on the mRNA expression of markers of BBB integrity in an age-accelerated mouse model. METHODS: Male and female Senescence …