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The Neuromodulatory And Hormonal Effects Of Transcutaneous Vagus Nerve Stimulation As Evidenced By Salivary Alpha Amylase, Salivary Cortisol, Pupil Diameter, And The P3 Event-Related Potential, Christopher M. Warren, Klodiana D. Tona, L. Ouwerkerk, Jeroen Van Paridon, Fenna Poletiek, Henk Van Steenbergen, Jos A. Bosch, Sander Nieuwenhuis
The Neuromodulatory And Hormonal Effects Of Transcutaneous Vagus Nerve Stimulation As Evidenced By Salivary Alpha Amylase, Salivary Cortisol, Pupil Diameter, And The P3 Event-Related Potential, Christopher M. Warren, Klodiana D. Tona, L. Ouwerkerk, Jeroen Van Paridon, Fenna Poletiek, Henk Van Steenbergen, Jos A. Bosch, Sander Nieuwenhuis
Psychology Faculty Publications
Background
Transcutaneous vagus nerve stimulation (tVNS) is a new, non-invasive technique being investigated as an intervention for a variety of clinical disorders, including epilepsy and depression. It is thought to exert its therapeutic effect by increasing central norepinephrine (NE) activity, but the evidence supporting this notion is limited.
Objective
In order to test for an impact of tVNS on psychophysiological and hormonal indices of noradrenergic function, we applied tVNS in concert with assessment of salivary alpha amylase (SAA) and cortisol, pupil size, and electroencephalograph (EEG) recordings.
Methods
Across three experiments, we applied real and sham tVNS to 61 healthy participants …