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Estrogen Receptor Alpha Controls Mitochondrial Function And Metabolic Homeostasis, And Is Critical For Exercise-Induced Improvements In Metabolism, Alexia M. Joseph
Estrogen Receptor Alpha Controls Mitochondrial Function And Metabolic Homeostasis, And Is Critical For Exercise-Induced Improvements In Metabolism, Alexia M. Joseph
International Journal of Exercise Science: Conference Proceedings
Skeletal muscle is an important tissue responsible for locomotion, oxidative metabolism, and insulin-stimulated glucose disposal. Because exercise is the most effective means to combat metabolic dysfunction and prevent the progression of type 2 diabetes, our laboratory is interested in understanding the molecular transducers underlying the health benefits of exercise. Previous work by our group has shown that muscle ESR1/ERα expression is correlated with indices of metabolic health, and Esr1 expression in muscle is induced following exercise training.
PURPOSE: Determine whether genetic overexpression of Esr1 to mimic transcript induction by physical activity is sufficient to produce favorable metabolic changes …