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Abnormal Electrophysiological Motor Responses In Huntington's Disease: Evidence Of Premanifest Compensation, Lauren Turner, Rodney J. Croft, Andrew Churchyard, Jeffrey C. L Looi, Deborah M. Apthorp, Nellie Georgiou-Karistianis
Abnormal Electrophysiological Motor Responses In Huntington's Disease: Evidence Of Premanifest Compensation, Lauren Turner, Rodney J. Croft, Andrew Churchyard, Jeffrey C. L Looi, Deborah M. Apthorp, Nellie Georgiou-Karistianis
Faculty of Social Sciences - Papers (Archive)
Background: Huntington's disease (HD) causes progressive motor dysfunction through characteristic atrophy. Changes to neural structure begin in premanifest stages yet individuals are able to maintain a high degree of function, suggesting involvement of supportive processing during motor performance. Electroencephalography (EEG) enables the investigation of subtle impairments at the neuronal level, and possible compensatory strategies, by examining differential activation patterns. We aimed to use EEG to investigate neural motor processing (via the Readiness Potential; RP), premotor processing and sensorimotor integration (Contingent Negative Variation; CNV) during simple motor performance in HD. Methods: We assessed neural activity associated with motor preparation and processing …