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Assessment Of Human Adipose Tissue Microvascular Function Using Videomicroscopy, Melissa G. Farb, Song-Young Park, Shakun Karki, Noyan Gokce
Assessment Of Human Adipose Tissue Microvascular Function Using Videomicroscopy, Melissa G. Farb, Song-Young Park, Shakun Karki, Noyan Gokce
Health and Kinesiology Faculty Publications
While obesity is closely linked to the development of metabolic and cardiovascular disease, little is known about mechanisms that govern these processes. It is hypothesized that pro-atherogenic mediators released from fat tissues particularly in association with central/visceral adiposity may promote pathogenic vascular changes locally and systemically, and the notion that cardiovascular disease may be the consequence of adipose tissue dysfunction continues to evolve. Here, we describe a unique method of videomicroscopy that involves analysis of vasodilator and vasoconstrictor responses of intact small human arterioles removed from the adipose depot of living human subjects. Videomicroscopy is used to examine functional properties …
Wnt5a Regulates Adipose Tissue Angiogenesis Via Antiangiogenic Vegf-A165b In Obese Humans, Melissa G. Farb, Doan T.M. Ngo, Song-Young Park, Samantha M. Saggese, Naomi M. Hamburg, Brian Carmine, Donald T. Hess, Kenneth Walsh, Noyan Gokce
Wnt5a Regulates Adipose Tissue Angiogenesis Via Antiangiogenic Vegf-A165b In Obese Humans, Melissa G. Farb, Doan T.M. Ngo, Song-Young Park, Samantha M. Saggese, Naomi M. Hamburg, Brian Carmine, Donald T. Hess, Kenneth Walsh, Noyan Gokce
Health and Kinesiology Faculty Publications
Experimental studies have suggested that Wingless-related integration site 5A (WNT5A) is a proinflammatory secreted protein that is associated with metabolic dysfunction in obesity. Impaired angiogenesis in fat depots has been implicated in the development of adipose tissue capillary rarefaction, hypoxia, inflammation, and metabolic dysfunction. We have recently demonstrated that impaired adipose tissue angiogenesis is associated with overexpression of antiangiogenic factor VEGF-A165b in human fat and the systemic circulation. In the present study, we postulated that upregulation of WNT5A is associated with angiogenic dysfunction and examined its role in regulating VEGF-A165b expression in human obesity. We biopsied subcutaneous and visceral adipose …