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Body Mass-Normalized Moderate Dose Of Dietary Nitrate Intake Improves Endothelial Function And Walking Capacity In Patients With Peripheral Artery Disease, Elizabeth J. Pekas, Tesean Wooden, Santosh K. Yadav, Song-Young Park
Body Mass-Normalized Moderate Dose Of Dietary Nitrate Intake Improves Endothelial Function And Walking Capacity In Patients With Peripheral Artery Disease, Elizabeth J. Pekas, Tesean Wooden, Santosh K. Yadav, Song-Young Park
Health and Kinesiology Faculty Publications
Peripheral artery disease (PAD) is characterized by the accumulation of atherosclerotic plaques in the lower extremity conduit arteries, which impairs blood flow and walking capacity. Dietary nitrate has been used to reduce blood pressure (BP) and improve walking capacity in PAD. However, a standardized dose for PAD has not been determined. Therefore, we sought to determine the effects of a body mass-normalized moderate dose of nitrate (0.11 mmol nitrate/kg) as beetroot juice on serum nitrate/nitrite, vascular function, walking capacity, and tissue oxygen utilization capacity in patients with PAD. A total of 11 patients with PAD received either nitrate supplement or …
Acute Mitochondrial Antioxidant Intake Improves Endothelial Function, Antioxidant Enzyme Activity, And Exercise Tolerance In Patients With Peripheral Artery Disease, Song-Young Park, Elizabeth J. Pekas, Ronald Headid Iii, Won-Mok Son, Tesean Wooden, Jiwon Song, Gwenael Layec, Santosh K. Yadav, Paras K. Mishra, Iraklis Pipinos
Acute Mitochondrial Antioxidant Intake Improves Endothelial Function, Antioxidant Enzyme Activity, And Exercise Tolerance In Patients With Peripheral Artery Disease, Song-Young Park, Elizabeth J. Pekas, Ronald Headid Iii, Won-Mok Son, Tesean Wooden, Jiwon Song, Gwenael Layec, Santosh K. Yadav, Paras K. Mishra, Iraklis Pipinos
Health and Kinesiology Faculty Publications
Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the leg arteries, which causes claudication. This may be in part due to vascular mitochondrial dysfunction and excessive reactive oxygen species (ROS) production. A mitochondrial-targeted antioxidant (MitoQ) has been shown to improve vascular mitochondrial function that, in turn, led to improved vascular function in older adults and animal models. However, the roles of vascular mitochondria in vascular function including endothelial function and arterial stiffness in patients with PAD are unknown; therefore, with the use of acute MitoQ intake, this study examined the roles of vascular mitochondria in endothelial function, arterial …
Low Intensity Resistance Exercise Training With Blood Flow Restriction: Insight Into Cardiovascular Function, And Skeletal Muscle Hypertrophy In Humans, Song-Young Park, Yi Sub Kwak, Andrew Harveson, Joshua C. Weavil, Kook E. Seo
Low Intensity Resistance Exercise Training With Blood Flow Restriction: Insight Into Cardiovascular Function, And Skeletal Muscle Hypertrophy In Humans, Song-Young Park, Yi Sub Kwak, Andrew Harveson, Joshua C. Weavil, Kook E. Seo
Health and Kinesiology Faculty Publications
Attenuated functional exercise capacity in elderly and diseased populations is a common problem, and stems primarily from physical inactivity. Decreased function and exercise capacity can be restored by maintaining muscular strength and mass, which are key factors in an independent and healthy life. Resistance exercise has been used to prevent muscle loss and improve muscular strength and mass. However, the intensities necessary for traditional resistance training to increase muscular strength and mass may be contraindicated for some at risk populations, such as diseased populations and the elderly. Therefore, an alternative exercise modality is required. Recently, blood flow restriction (BFR) with …