Education Commons^™

Sympathoinhibition And Vasodilation Contribute To The Acute Hypotensive Response Of The Superoxide Dismutase Mimic, Mntnbuoe-2-Pyp5+, In Hypertensive Animals, Sarah L. Schlichte, Elizabeth J. Pekas, Taylor J. Bruett, Elizabeth A. Kosmacek, Bryan T. Hackfort, Jordan M. Rasmussen, Kaushik P. Patel, Song-Young Park, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman

Health and Kinesiology Faculty Publications

The pathogenesis of hypertension has been linked to excessive levels of reactive oxygen species (ROS), particularly superoxide (O2•−), in multiple tissues and organ systems. Overexpression of superoxide dismutase (SOD) to scavenge O2•− has been shown to decrease blood pressure in hypertensive animals. We have previously shown that MnTnBuOE-2-PyP5+ (BuOE), a manganese porphyrin SOD mimic currently in clinical trials as a normal tissue protector for cancer patients undergoing radiation therapy, can scavenge O2•− and acutely decrease normotensive blood pressures. Herein, we hypothesized that BuOE decreases hypertensive blood pressures. Using angiotensin II (AngII)-hypertensive mice, we demonstrate that BuOE administered both intraperitoneally and …

The Effects Of Mat Pilates Training On Vascular Function And Body Fatness In Obese Young Women With Elevated Blood Pressure, Alexei Wong, Arturo Figueroa, Stephen M. Fischer, Reza Bagheri, Song-Young Park

Health and Kinesiology Faculty Publications

BACKGROUND

Effective nonpharmacological interventions targeting the enhancement of vascular function and decline of body fatness (BF) in obese individuals are indispensable for the prevention of hypertension and cardiovascular events in young adults. Mat Pilates training (MPT) has gained significant popularity worldwide, yet its effects on vascular function and body composition are understudied. We examined the effects of MPT on vascular function and BF in young obese women with elevated blood pressure (BP). METHODS

Twenty-eight young obese women with elevated BP were randomized to an MPT (n = 14) or a nonexercising control (CON, n = 14) group for 12 …

Taekwondo Training Reduces Blood Catecholamine Levels And Arterial Stiffness In Postmenopausal Women With Stage-2 Hypertension: Randomized Clinical Trial, Sang-Ho Lee, Steven D. Scott, Elizabeth J. Pekas, Seungyong Lee, Seok Hoon Lee, Song-Young Park

Health and Kinesiology Faculty Publications

Objective: Menopause is associated with a progressive impairment of vascular function and muscular strength in women. Accordingly, the purpose of this study was to determine if Taekwondo training could improve blood catecholamine levels, arterial stiffness, blood pressure (BP) and skeletal muscle strength in postmenopausal women with stage-2 hypertension.

Methods: 20 postmenopausal women (70 ± 4 years old) with stage-2 hypertension were randomly assigned to a 1) Taekwondo training (TT; n = 10) or 2) Control (CON; n = 10) group. Taekwondo training was performed for 60 minutes/day, 3 days/week for 12-weeks.

Results: There were significant (P …

Combined Exercise Training Reduces Blood Pressure, Arterial Stiffness, And Insulin Resistance In Obese Prehypertensive Adolescent Girls, Won-Mok Son, Ki-Dong Sung, Leena P. Bharath, Kong-Jib Choi, Song-Young Park

Health and Kinesiology Faculty Publications

Childhood obesity is strongly linked to pathological processes for cardiovascular diseases in later adulthood. Obese adolescent girls with high blood pressure (BP) are reported to have increased arterial stiffness, which is associated with the development of hypertension and atherosclerosis. The present study sought to examine the impact of combined resistance and aerobic exercise (CRAE) training on BP, brachial-ankle pulse wave velocity (baPWV), insulin resistance (IR), and body composition in obese prehypertensive girls. Forty girls (age, 15 ± 1 years; systolic BP, 132 ± 2 mmHg, diastolic BP, 80 ± 5 mmHg) were randomly assigned to either a combined exercise (EX, …