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Impact Of Age On The Vasodilatory Function Of Human Skeletal Muscle Feed Arteries, Song-Young Park, S. J. Ives, J. R. Gifford, R. H. I. Andtbacka, John R. Hyngstrom, Van Reese, Gwenael Layec, Leena P. Bharath, J. David Symons, Russell S. Richardson
Impact Of Age On The Vasodilatory Function Of Human Skeletal Muscle Feed Arteries, Song-Young Park, S. J. Ives, J. R. Gifford, R. H. I. Andtbacka, John R. Hyngstrom, Van Reese, Gwenael Layec, Leena P. Bharath, J. David Symons, Russell S. Richardson
Health and Kinesiology Faculty Publications
Although advancing age is often associated with attenuated skeletal muscle blood flow and skeletal muscle feed arteries (SMFAs) have been recognized to play a regulatory role in the vasculature, little is known about the impact of age on the vasodilatory capacity of human SMFAs. Therefore, endothelium-dependent and -independent vasodilation were assessed in SMFAs (diameter: 544 ± 63 μm) obtained from 24 (equally represented) young (33 ± 2 yr) and old (71 ± 2 yr) subjects in response to three stimuli: 1) flow-induced shear stress, 2) ACh, and 3) sodium nitropusside (SNP). Both assessments of endothelium-dependent vasodilation, flow …