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Full-Text Articles in Education
Strong Relationship Between Vascular Function In The Coronary And Brachial Arteries: A Clinical Coming Of Age For The Updated Flow-Mediated Dilation Test?, Ryan M. Broxterman, Melissa A. Witman, Joel D. Trinity, H. Jonathan Groot, Matthew J. Rossman, Song-Young Park, Simon Malenfant, Jayson R. Gifford, Oh-Sung Kwon, Soung Hun Park, Catherine L. Jarrett, Katherine L. Shields, Jay R. Hydren, Angela V. Bisconti, Theophilus Owan, Anu Abraham, Anwar Tandar, Charles Y. Lui, Brigham R. Smith, Russell S. Richardson
Strong Relationship Between Vascular Function In The Coronary And Brachial Arteries: A Clinical Coming Of Age For The Updated Flow-Mediated Dilation Test?, Ryan M. Broxterman, Melissa A. Witman, Joel D. Trinity, H. Jonathan Groot, Matthew J. Rossman, Song-Young Park, Simon Malenfant, Jayson R. Gifford, Oh-Sung Kwon, Soung Hun Park, Catherine L. Jarrett, Katherine L. Shields, Jay R. Hydren, Angela V. Bisconti, Theophilus Owan, Anu Abraham, Anwar Tandar, Charles Y. Lui, Brigham R. Smith, Russell S. Richardson
Health and Kinesiology Faculty Publications
Early detection of coronary artery dysfunction is of paramount cardiovascular clinical importance, but a noninvasive assessment is lacking. Indeed, the brachial artery flow-mediated dilation test only weakly correlated with acetylcholine-induced coronary artery function (r=0.36). However, brachial artery flow-mediated dilation methodologies have, over time, substantially improved. This study sought to determine if updates to this technique have improved the relationship with coronary artery function and the noninvasive indication of coronary artery dysfunction. Coronary artery and brachial artery function were assessed in 28 patients referred for cardiac catheterization (61±11 years). Coronary artery function was determined by the change in artery diameter with …
Assessment Of Human Adipose Tissue Microvascular Function Using Videomicroscopy, Melissa G. Farb, Song-Young Park, Shakun Karki, Noyan Gokce
Assessment Of Human Adipose Tissue Microvascular Function Using Videomicroscopy, Melissa G. Farb, Song-Young Park, Shakun Karki, Noyan Gokce
Health and Kinesiology Faculty Publications
While obesity is closely linked to the development of metabolic and cardiovascular disease, little is known about mechanisms that govern these processes. It is hypothesized that pro-atherogenic mediators released from fat tissues particularly in association with central/visceral adiposity may promote pathogenic vascular changes locally and systemically, and the notion that cardiovascular disease may be the consequence of adipose tissue dysfunction continues to evolve. Here, we describe a unique method of videomicroscopy that involves analysis of vasodilator and vasoconstrictor responses of intact small human arterioles removed from the adipose depot of living human subjects. Videomicroscopy is used to examine functional properties …
Wnt5a-Jnk Regulation Of Vascular Insulin Resistance In Human Obesity, Melissa G. Farb, Shakun Karki, Song-Young Park, Samantha M. Saggese, Brian Carmine, Donald T. Hess, Caroline Apovian, Jessica L. Fetterman, Rosa Breton-Romero, Naomi M. Hamburg, Jose J. Fuster, Maria A. Zuriaga, Kenneth Walsh, Noyan Gokce
Wnt5a-Jnk Regulation Of Vascular Insulin Resistance In Human Obesity, Melissa G. Farb, Shakun Karki, Song-Young Park, Samantha M. Saggese, Brian Carmine, Donald T. Hess, Caroline Apovian, Jessica L. Fetterman, Rosa Breton-Romero, Naomi M. Hamburg, Jose J. Fuster, Maria A. Zuriaga, Kenneth Walsh, Noyan Gokce
Health and Kinesiology Faculty Publications
Obesity is associated with the development of vascular insulin resistance; however, pathophysiological mechanisms are poorly understood. We sought to investigate the role of WNT5A-JNK in the regulation of insulin-mediated vasodilator responses in human adipose tissue arterioles prone to endothelial dysfunction. In 43 severely obese (BMI 44±11 kg/m2) and five metabolically normal non-obese (BMI 26±2 kg/m2) subjects, we isolated arterioles from subcutaneous and visceral fat during planned surgeries. Using videomicroscopy, we examined insulin-mediated, endothelium-dependent vasodilator responses and characterized adipose tissue gene and protein expression using real-time polymerase chain reaction and Western blot analyses. Immunofluorescence was used to quantify endothelial nitric oxide …