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Full-Text Articles in Education
Altered Skeletal Muscle Mitochondrial Phenotype In Copd: Disease Vs. Disuse, Jayson R. Gifford, Joel D. Trinity, Oh-Sung Kwon, Gwenael Layec, Ryan S. Garten, Song-Young Park, Ashley D. Nelson, Russell S. Richardson
Altered Skeletal Muscle Mitochondrial Phenotype In Copd: Disease Vs. Disuse, Jayson R. Gifford, Joel D. Trinity, Oh-Sung Kwon, Gwenael Layec, Ryan S. Garten, Song-Young Park, Ashley D. Nelson, Russell S. Richardson
Health and Kinesiology Faculty Publications
Patients with chronic obstructive pulmonary disease (COPD) exhibit an altered skeletal muscle mitochondrial phenotype, which often includes reduced mitochondrial density, altered respiratory function, and elevated oxidative stress. As this phenotype may be explained by the sedentary lifestyle that commonly accompanies this disease, the aim of this study was to determine whether such alterations are still evident when patients with COPD are compared to control subjects matched for objectively measured physical activity (PA; accelerometry). Indexes of mitochondrial density [citrate synthase (CS) activity], respiratory function (respirometry in permeabilized fibers), and muscle oxidative stress [4-hydroxynonenal (4-HNE) content] were assessed in muscle fibers biopsied …
Quadriceps Exercise Intolerance In Patients With Chronic Obstructive Pulmonary Disease: The Potential Role Of Altered Skeletal Muscle Mitochondrial Respiration, J. R. Gifford, Joel D. Trinity, Gwenael Layec, Ryan S. Garten, Song-Young Park, Matthew J. Rossman, Steen Larsen, Flemming Dela, Russell S. Richardson
Quadriceps Exercise Intolerance In Patients With Chronic Obstructive Pulmonary Disease: The Potential Role Of Altered Skeletal Muscle Mitochondrial Respiration, J. R. Gifford, Joel D. Trinity, Gwenael Layec, Ryan S. Garten, Song-Young Park, Matthew J. Rossman, Steen Larsen, Flemming Dela, Russell S. Richardson
Health and Kinesiology Faculty Publications
This study sought to determine if qualitative alterations in skeletal muscle mitochondrial respiration, associated with decreased mitochondrial efficiency, contribute to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). Using permeabilized muscle fibers from the vastus lateralis of 13 patients with COPD and 12 healthy controls, complex I (CI) and complex II (CII)-driven State 3 mitochondrial respiration were measured separately (State 3:CI and State 3:CII) and in combination (State 3:CI+CII). State 2 respiration was also measured. Exercise tolerance was assessed by knee extensor exercise (KE) time to fatigue. Per milligram of muscle, State 3:CI+CII and State 3:CI were reduced …