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Full-Text Articles in Education
Salt Restriction Lowers Blood Pressure At Rest And During Exercise Without Altering Peripheral Hemodynamics In Hypertensive Individuals, Stephen M. Ratchford, Ryan M. Broxterman, Taylor La Salle, Oh-Sung Kwon, Song-Young Park, Paul N. Hopkins, Russell S. Richardson, Joel D. Trinity
Salt Restriction Lowers Blood Pressure At Rest And During Exercise Without Altering Peripheral Hemodynamics In Hypertensive Individuals, Stephen M. Ratchford, Ryan M. Broxterman, Taylor La Salle, Oh-Sung Kwon, Song-Young Park, Paul N. Hopkins, Russell S. Richardson, Joel D. Trinity
Health and Kinesiology Faculty Publications
Dietary salt restriction is a well-established approach to lower blood pressure and reduce cardiovascular disease risk in hypertensive individuals. However, little is currently known regarding the effects of salt restriction on central and peripheral hemodynamic responses to exercise in those with hypertension. Therefore, this study sought to determine the impact of salt restriction on the central and peripheral hemodynamic responses to static-intermittent handgrip (HG) and dynamic single-leg knee extension (KE) exercise in individuals with hypertension. Twenty-two subjects (14 men and 8 women, 51 ± 10 yr, 173 ± 11 cm, 99 ± 23 kg) forewent their antihypertensive medication use for …
Trpv1 Channels In Human Skeletal Muscle Feed Arteries: Implications For Vascular Function, Stephen J. Ives, Song-Young Park, Oh-Sung Kwon, Jayson R. Gifford, Robert H. I. Andtbacka, John R. Hyngstrom, Russell S. Richardson
Trpv1 Channels In Human Skeletal Muscle Feed Arteries: Implications For Vascular Function, Stephen J. Ives, Song-Young Park, Oh-Sung Kwon, Jayson R. Gifford, Robert H. I. Andtbacka, John R. Hyngstrom, Russell S. Richardson
Health and Kinesiology Faculty Publications
New Findings
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What is the central question of this study?
We sought to determine whether human skeletal muscle feed arteries (SFMAs) express TRPV1 channels and what role they play in modulating vascular function.
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What is the main finding and its importance?
Human SMFAs do express functional TRPV1 channels that modulate vascular function, specifically opposing α-adrenergic receptor-mediated vasocontraction and potentiating vasorelaxation, in an endothelium-dependent manner, as evidenced by the α1-receptor-mediated responses. Thus, the vasodilatory role of TRPV1 channels, and their ligand capsaicin, could be a potential therapeutic target for improving vascular function. Additionally, given the ‘sympatholytic’ effect of TRPV1 activation and …