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Mmp9 Mediates Acute Hyperglycemia-Induced Human Cardiac Stem Cell Death By Upregulating Apoptosis And Pyroptosis In Vitro, Santosh K. Yadav, Tyler N. Kambis, Sumit Kar, Song-Young Park, Paras K. Mishra
Mmp9 Mediates Acute Hyperglycemia-Induced Human Cardiac Stem Cell Death By Upregulating Apoptosis And Pyroptosis In Vitro, Santosh K. Yadav, Tyler N. Kambis, Sumit Kar, Song-Young Park, Paras K. Mishra
Health and Kinesiology Faculty Publications
Providing a conducive microenvironment is critical to increase survival of transplanted stem cells in regenerative therapy. Hyperglycemia promotes stem cell death impairing cardiac regeneration in the diabetic heart. Understanding the molecular mechanisms of high glucose-induced stem cell death is important for improving cardiac regeneration in diabetic patients. Matrix metalloproteinase-9 (MMP9), a collagenase, is upregulated in the diabetic heart, and ablation of MMP9 decreases infarct size in the non-diabetic myocardial infarction heart. In the present study, we aim to investigate whether MMP9 is a mediator of hyperglycemia-induced cell death in human cardiac stem cells (hCSCs) in vitro. We created MMP9−/− hCSCs …