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Strong Relationship Between Vascular Function In The Coronary And Brachial Arteries: A Clinical Coming Of Age For The Updated Flow-Mediated Dilation Test?, Ryan M. Broxterman, Melissa A. Witman, Joel D. Trinity, H. Jonathan Groot, Matthew J. Rossman, Song-Young Park, Simon Malenfant, Jayson R. Gifford, Oh-Sung Kwon, Soung Hun Park, Catherine L. Jarrett, Katherine L. Shields, Jay R. Hydren, Angela V. Bisconti, Theophilus Owan, Anu Abraham, Anwar Tandar, Charles Y. Lui, Brigham R. Smith, Russell S. Richardson

Health and Kinesiology Faculty Publications

Early detection of coronary artery dysfunction is of paramount cardiovascular clinical importance, but a noninvasive assessment is lacking. Indeed, the brachial artery flow-mediated dilation test only weakly correlated with acetylcholine-induced coronary artery function (r=0.36). However, brachial artery flow-mediated dilation methodologies have, over time, substantially improved. This study sought to determine if updates to this technique have improved the relationship with coronary artery function and the noninvasive indication of coronary artery dysfunction. Coronary artery and brachial artery function were assessed in 28 patients referred for cardiac catheterization (61±11 years). Coronary artery function was determined by the change in artery diameter with …