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Impacts Of Mitochondrial-Targeted Antioxidant (Mitoq) On Skeletal Muscle Mitochondrial Function In Peripheral Arterial Disease Patients, Jiwon Song

UNO Student Research and Creative Activity Fair

Peripheral arterial disease (PAD) is an atherosclerotic disease that affects the arteries in the legs, causing decreased blood flow and oxygen transfer capacity to the skeletal muscle. This ischemia in the skeletal muscle in PAD patients may result in increased inflammation and mitochondrial dysfunction due to increased reactive oxygen species (ROS) production. Inflammation and ROS production have been shown to attenuate vascular function in PAD patients Mitochondrial-targeted antioxidants (such as MitoQ) have been shown to combat ROS and inflammation in various diseases.

Purpose: We sought to examine the impacts of MitoQ intake on vascular function measurements in PAD patients. …