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Α1- And Α2-Adrenergic Responsiveness In Human Skeletal Muscle Feed Arteries: The Role Of Trpv Ion Channels In Heat-Induced Sympatholysis, J. R. Gifford, S. J. Ives, Song-Young Park, R. H. I. Andtbacka, John R. Hyngstrom, Michelle T. Mueller, Gerald S. Treinman, Christopher Ward, Joel D. Trinity, Russell S. Richardson
Α1- And Α2-Adrenergic Responsiveness In Human Skeletal Muscle Feed Arteries: The Role Of Trpv Ion Channels In Heat-Induced Sympatholysis, J. R. Gifford, S. J. Ives, Song-Young Park, R. H. I. Andtbacka, John R. Hyngstrom, Michelle T. Mueller, Gerald S. Treinman, Christopher Ward, Joel D. Trinity, Russell S. Richardson
Health and Kinesiology Faculty Publications
The purpose of this study was to determine if heat inhibits α2-adrenergic vasocontraction, similarly to α1-adrenergic contraction, in isolated human skeletal muscle feed arteries (SMFA) and elucidate the role of the temperature-sensitive vanilloid-type transient receptor potential (TRPV) ion channels in this response. Isolated SMFA from 37 subjects were studied using wire myography. α1 [Phenylephrine (PE)]- and α2 [dexmedetomidine (DEX)]-contractions were induced at 37 and 39°C with and without TRPV family and TRPV4-specific inhibition [ruthenium red (RR) and RN-1734, respectively]. Endothelial function [acetylcholine (ACh)] and smooth muscle function [sodium nitroprusside (SNP) and potassium chloride (KCl)] were also assessed under these conditions. …