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Variability Of The Aerodynamic Measures Of Leporine Larynges Exposed To Inhaled Corticosteroids, Miriam Angela Cannon Bake
Variability Of The Aerodynamic Measures Of Leporine Larynges Exposed To Inhaled Corticosteroids, Miriam Angela Cannon Bake
Theses and Dissertations
This thesis examined the effects of combination inhaled corticosteroids (ICs) on the stability of six aerodynamic measures of phonation utilizing a traditional benchtop model with leporine larynges. The motivation for this study was based on the increase of voice disorders associated with IC use in recent years. The aerodynamic measures examined were phonation threshold pressure (PTP), phonation threshold flow (PTF), onset resistance, sustained pressure, sustained flow, and sustained resistance. Leporine larynges were selected as the model for this study due to histological similarities between leporine and human vocal folds that make them ideal for translational research. Rabbits were either exposed …
Effects Of Inhaled Combination Corticosteroid Drugs On Aerodynamic Measures Of Phonation And Visual-Perceptual Measures Of Vocal Fold And Arytenoid Tissue In Excised Rabbit Larynges, Christina Lynn Pang
Effects Of Inhaled Combination Corticosteroid Drugs On Aerodynamic Measures Of Phonation And Visual-Perceptual Measures Of Vocal Fold And Arytenoid Tissue In Excised Rabbit Larynges, Christina Lynn Pang
Theses and Dissertations
The purpose of this thesis is to examine the effects of inhaled corticosteroid drugs (ICs) on the voice due to their frequent use in treating an increasing prevalence of asthma disorders. As part of a larger five-year study, the focus of this thesis is specifically on whether 8 weeks of in vivo exposure to ICs will cause changes in the sustained subglottal pressure, sustained airflow, and visual-perceptual ratings of edema and erythema in excised rabbit larynges. Researchers administered either ICs or a control nebulized isotonic saline solution to 22 rabbits in vivo, sacrificed them, and harvested their larynges for benchtop …