Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Education
Acute Mitochondrial Antioxidant Intake Improves Endothelial Function, Antioxidant Enzyme Activity, And Exercise Tolerance In Patients With Peripheral Artery Disease, Song-Young Park, Elizabeth J. Pekas, Ronald Headid Iii, Won-Mok Son, Tesean Wooden, Jiwon Song, Gwenael Layec, Santosh K. Yadav, Paras K. Mishra, Iraklis Pipinos
Acute Mitochondrial Antioxidant Intake Improves Endothelial Function, Antioxidant Enzyme Activity, And Exercise Tolerance In Patients With Peripheral Artery Disease, Song-Young Park, Elizabeth J. Pekas, Ronald Headid Iii, Won-Mok Son, Tesean Wooden, Jiwon Song, Gwenael Layec, Santosh K. Yadav, Paras K. Mishra, Iraklis Pipinos
Health and Kinesiology Faculty Publications
Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the leg arteries, which causes claudication. This may be in part due to vascular mitochondrial dysfunction and excessive reactive oxygen species (ROS) production. A mitochondrial-targeted antioxidant (MitoQ) has been shown to improve vascular mitochondrial function that, in turn, led to improved vascular function in older adults and animal models. However, the roles of vascular mitochondria in vascular function including endothelial function and arterial stiffness in patients with PAD are unknown; therefore, with the use of acute MitoQ intake, this study examined the roles of vascular mitochondria in endothelial function, arterial …
Vasodilatory And Vascular Mitochondrial Respiratory Function With Advancing Age: Evidence Of A Free Radically Mediated Link In The Human Vasculature, Soung Hun Park, Oh-Sung Kwon, Song-Young Park, Joshua C. Weavil, Jay R. Hydren, Van Reese, Robert H. I. Andtbacka, John R. Hyngstrom, Russell S. Richardson
Vasodilatory And Vascular Mitochondrial Respiratory Function With Advancing Age: Evidence Of A Free Radically Mediated Link In The Human Vasculature, Soung Hun Park, Oh-Sung Kwon, Song-Young Park, Joshua C. Weavil, Jay R. Hydren, Van Reese, Robert H. I. Andtbacka, John R. Hyngstrom, Russell S. Richardson
Health and Kinesiology Faculty Publications
Recognizing the age-related decline in skeletal muscle feed artery (SMFA) vasodilatory function, this study examined the link between vasodilatory and mitochondrial respiratory function in the human vasculature. Twenty-four SMFAs were harvested from young (35 ± 6 yr, n = 9) and old (71 ± 9 yr, n = 15) subjects. Vasodilation in SMFAs was assessed, by pressure myography, in response to flow-induced shear stress, acetylcholine (ACh), and sodium nitroprusside (SNP) while mitochondrial respiration was measured, by respirometry, in permeabilized SMFAs. Endothelium-dependent vasodilation was significantly attenuated in the old, induced by both flow (young: 92 ± 3, old: 45 ± 4%) …