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The Effect Of Acute And Chronic Thermotherapy On Type 2 Diabetic Skeletal Muscle Cell Viability And Gene Expression: Pilot Study, Louay Bachnak, Jean Sparks, Xavier F. Gonzales, Daniel Newmire, Felix Omoruyi
The Effect Of Acute And Chronic Thermotherapy On Type 2 Diabetic Skeletal Muscle Cell Viability And Gene Expression: Pilot Study, Louay Bachnak, Jean Sparks, Xavier F. Gonzales, Daniel Newmire, Felix Omoruyi
International Journal of Exercise Science: Conference Proceedings
Diabetes is a chronic metabolic disease affecting millions of people globally. Type 2 diabetes is associated with insulin resistance or a defective secretion of insulin from the pancreas. The skeletal muscle system accounts for 80% of glucose uptake and is a vital player in healthy aging and muscle mass maintenance. PURPOSE: The purpose of this study was to investigate the effects of thermotherapy on gene expression and cell viability in Type 2 Diabetic skeletal muscle. METHODS: Human skeletal muscle myoblast (HSMM) and Diabetic Type 2 human skeletal muscle myoblast (D-HSMM) (Lonza Inc, Walkersville, MD) were cultured until 90% confluency was, …
Disuse Atrophy Occurs Without A Change In Mitochondrial Respiratory Control Ratio During Hindlimb Unloading In Mice, Indu Reddy Enukonda, Megan E. Rosa-Caldwell, David E. Lee, Jacob L. Brown, Richard A. Perry, Tyrone A. Washington, Nicholas P. Greene, Michael P. Wiggs
Disuse Atrophy Occurs Without A Change In Mitochondrial Respiratory Control Ratio During Hindlimb Unloading In Mice, Indu Reddy Enukonda, Megan E. Rosa-Caldwell, David E. Lee, Jacob L. Brown, Richard A. Perry, Tyrone A. Washington, Nicholas P. Greene, Michael P. Wiggs
International Journal of Exercise Science: Conference Proceedings
Skeletal muscle atrophy commonly occurs during prolonged periods of inactivity, however, the precise mechanisms that cause muscle atrophy have yet to be determined. Specifically, a controversy exists on whether mitochondrial dysfunction is a cause or consequence of disuse muscle atrophy. PURPOSE: The purpose of this study was to determine if a change in the respiratory control ratio, which is a ratio of maximal O2 respiration to leak respiration, could be detected prior to muscle atrophy in a time-course study in mice. METHODS: Disuse atrophy was induced using hindlimb unloading (HU) in adult, C57BL/6J male mice for 0 …
Replicating Intermittent Fasting In Human Skeletal Muscle Cells: A Pilot Study, Lael K. Ceriani, Felix Omoruyi, Jean Sparks, Daniel E. Newmire, Xavier F. Gonzales
Replicating Intermittent Fasting In Human Skeletal Muscle Cells: A Pilot Study, Lael K. Ceriani, Felix Omoruyi, Jean Sparks, Daniel E. Newmire, Xavier F. Gonzales
International Journal of Exercise Science: Conference Proceedings
Type 2 diabetes (T2D), the most common form of diabetes (90-95% of diagnoses), is marked by decreased insulin sensitivity (insulin resistance) or a defect in insulin secretion. T2D disrupts nutrient signaling where the body cannot maintain adequate blood glucose levels. Inability to receive glucose in skeletal muscle due to insulin resistance in T2D results in oxidative stress and increased muscle atrophy. Properly regulated glucose uptake is pivotal for healthy aging and maintenance of the skeletal muscle system. PURPOSE: The purpose of this study is to examine the effects of nutrient deprivation on human skeletal muscle metabolism, with an emphasis …
A Comparison Of High-Intensity Interval Running And Tabata On Post-Exercise Metabolism, Lauren E. Pate
A Comparison Of High-Intensity Interval Running And Tabata On Post-Exercise Metabolism, Lauren E. Pate
International Journal of Exercise Science: Conference Proceedings
It is unclear how post-exercise metabolism would compare following the completion of 2 different modes of high-intensity exercise. PURPOSE: Compare the effects of high-intensity interval running (HIIR) and Tabata when performed at a similar duration and intensity. METHODS: Recreationally active individuals (n = 7; 6F, 1M; age = 22.2 ± 2.1 yrs; body mass = 64.2 ± 12.0 kg; body fat% = 26.2±3.1) completed 1) a rest bout, 2) a Tabata bout using only body callisthenic exercises, and 3) a bout of high-intensity interval running (HIIR) on a motorized treadmill. Participants performed each of the 3 bouts on separate …
Acute Maltodextrin Supplementation During Resistance Exercise, Dylan T. Wilburn, Steven Machek, Tom Cardaci, Paul Hwang, Darryn Willoughby
Acute Maltodextrin Supplementation During Resistance Exercise, Dylan T. Wilburn, Steven Machek, Tom Cardaci, Paul Hwang, Darryn Willoughby
International Journal of Exercise Science: Conference Proceedings
PURPOSE: Most of the research investigating the ergogenic enhancing mechanisms of carbohydrate have been conducted using aerobic based exercise. Therefore, the purpose of this study was to investigate the effects of pre-exercise maltodextrin ingestion on resistance exercise performance, serum insulin, epinephrine, glucose, and muscle glycogen concentrations. METHODS: In a double blind, cross over, repeated measures design, participants completed four sets to failure at 70% of 1-RM with 45s rest on the angled leg press with or without pre-exercise maltodextrin (2g/kg) after a 3hr fast. Serum glucose, epinephrine, and insulin were assessed at baseline, 30 min post-ingestion, immediately after, and 1hr …
Ubiquitin Proteasome System Activity Is Suppressed By Curcumin Following Exercise-Induced Muscle Damage In Human Skeletal Muscle, Thomas D. Cardaci, Steven B. Machek, Dylan T. Wilburn, Paul S. Hwang, Darryn Willoughby Phd
Ubiquitin Proteasome System Activity Is Suppressed By Curcumin Following Exercise-Induced Muscle Damage In Human Skeletal Muscle, Thomas D. Cardaci, Steven B. Machek, Dylan T. Wilburn, Paul S. Hwang, Darryn Willoughby Phd
International Journal of Exercise Science: Conference Proceedings
PURPOSE: Curcumin is a natural polyphenolic compound with antioxidant and anti-inflammatory properties. In vitro and in vivo animal studies have demonstrated that exposure to curcumin leads to dysregulation of the ubiquitin-proteasome system (UPS). However, to date, no study has investigated curcumin’s ability to influence UPS activity in a human model. Therefore, the purpose of this study was to investigate the effects of curcumin supplementation on markers of UPS activity in the presence of elevations in UPS activity due to exercise-induced muscle damage. METHODS: Twenty-three recreationally active male and female participants between the ages of 18-30 were randomized into …
Plasma Lipid, Glucose, And Immune Responses To Consumption Of Nutritive And Nonnutritive Sweeteners And Exercise, Jarrett Walbolt, Yunsuk Koh
Plasma Lipid, Glucose, And Immune Responses To Consumption Of Nutritive And Nonnutritive Sweeteners And Exercise, Jarrett Walbolt, Yunsuk Koh
International Journal of Exercise Science: Conference Proceedings
Although nonnutritive sweeteners are widely used as substitutes for nutritive sweeteners, it is currently uncertain how these commonly available sweeteners affect plasma glucose and lipid metabolism. PURPOSE: To examine how nutritive and nonnutritive sweeteners influence plasma lipid profiles, complete blood counts, and plasma glucose content at rest and during exercise. METHODS: This randomized, double-blinded, cross-over design study included 9 healthy, college aged, individuals (4 females and 5 males). In four separate visits, participants consumed 8 oz of sweetened drink in random order with either 445mg of stevia, 507mg of aspartame, 169mg of sucralose, or 110,000mg of sucrose mixed into water. …
Impact Of Astaxanthin Supplementation On Postprandial Oxidative Stress, Liliana I. Renteria, Matthew J. Mcallister
Impact Of Astaxanthin Supplementation On Postprandial Oxidative Stress, Liliana I. Renteria, Matthew J. Mcallister
International Journal of Exercise Science: Conference Proceedings
Astaxanthin is a naturally occurring carotenoid found in salmon and microalgae that has antioxidative properties. Previous research shows dietary supplementation may result in increased endogenous antioxidant status and reduced markers of oxidative stress (OS). Research suggests OS causes increased risk for cardiometabolic and other chronic diseases, making it important to find interventions that can decrease occurrence of OS. While astaxanthin has been shown to be antioxidative, most studies observing the impact of astaxanthin has on OS has involved rodent models, therefore human trials are needed. PURPOSE: The purpose of this study was to assess whether four weeks of astaxanthin supplementation …
Improved Glucose Tolerance And Glucose Utilization With Neuromuscular Electrical Stimulation, Michael J. Sanchez, Michelle Galvan, Dante Nacim, Sudip Bajpeyi
Improved Glucose Tolerance And Glucose Utilization With Neuromuscular Electrical Stimulation, Michael J. Sanchez, Michelle Galvan, Dante Nacim, Sudip Bajpeyi
International Journal of Exercise Science: Conference Proceedings
Sedentariness and increased body fat are the leading risk factors for developing insulin resistance, obesity, and type 2 diabetes. We have shown that muscle contraction induced by electrical pulse stimulation increase GLUT4 content in an in vitro primary cell culture model. Neuromuscular electrical stimulation (NMES) is a novel alternative strategy to induce muscle contraction in humans. Although widely used in rehabilitation settings to prevent muscle atrophy, effectiveness of NMES-induced muscle contractions in improving metabolic health is not clear. PURPOSE: To investigate the effects of four weeks of NMES on glucose tolerance, substrate utilization, and muscle mass in a sedentary overweight/obese …
A Comparison Of The Effects Of Moderate-Intensity Continuous Cycling And High-Intensity Interval Cycling On Postprandial Lipemia And Glycemia, Autumn Oliver, David J. Buckley, James R. Rowe Jr
A Comparison Of The Effects Of Moderate-Intensity Continuous Cycling And High-Intensity Interval Cycling On Postprandial Lipemia And Glycemia, Autumn Oliver, David J. Buckley, James R. Rowe Jr
International Journal of Exercise Science: Conference Proceedings
Both moderate-intensity continuous exercise (MICE) and high-intensity interval exercise (HIIE) has been reported to reduce the magnitude of postprandial lipemia and glycemia. It is unclear if performing MICE or HIIE of similar duration and work would have a comparable effect on postprandial lipemia or glycemia. PURPOSE: Examine the postprandial lipemic and glycemic response following the completion of high-intensity interval cycling (HIIC) and moderate-intensity continuous cycling (MICC) that is of equal duration and comparable work output. METHODS: Participants were mildly active males (n = 12; age = 21.9 ± 1.8 yrs; body mass = 90.1 ± 16.8 kg; BF% = …
No Changes In Appetite Stimulating Hormones Following Swimming And Cycling Exercise Interventions, Brandon G. Fico, Mohammed Alkatan, Yuzi Zhang, Hirofumi Tanaka
No Changes In Appetite Stimulating Hormones Following Swimming And Cycling Exercise Interventions, Brandon G. Fico, Mohammed Alkatan, Yuzi Zhang, Hirofumi Tanaka
International Journal of Exercise Science: Conference Proceedings
Swimming is a favorable and ideal modality of exercise for individuals with obesity and arthritis as it encompasses a minimal weight-bearing stress and a reduced heat load. However, the available evidence indicates that regular swimming may not be effective in reducing body weight and body fatness. A current hypothesis is that exercise in cold water somehow stimulates appetite. PURPOSE: We determined the effect of swimming exercise training on fasting concentrations of ghrelin, insulin, leptin, and peptide YY in obese individuals with osteoarthritis. Cycling training was included as a non-weight bearing land-based comparison group. METHODS: Thirty-nine obese participants with …
Acute Vs. Chronic Citrulline Malate Supplementation On Muscle Fatigue, Alyssa N. Fick, Tyler M. Farney, Matthew S. Stone, Robert J. Kowalsky, Christopher M. Hearon
Acute Vs. Chronic Citrulline Malate Supplementation On Muscle Fatigue, Alyssa N. Fick, Tyler M. Farney, Matthew S. Stone, Robert J. Kowalsky, Christopher M. Hearon
International Journal of Exercise Science: Conference Proceedings
Citrulline malate has been proposed to aid in reducing fatigue by increasing blood flow through promoting an increase in the nitric oxide synthase pathway along with the ability to remove ammonia and lactate accumulations. Results on the effectiveness of an acute supplementation are mixed, but it is proposed that regular consumption may help to attenuate the onset of fatigue during exercise. PURPOSE: To investigate the effects of acute and chronic citrulline malate supplementation on fatigue rate of the quadriceps. METHODS: Recreationally trained males (n=18, 24±5 yr, 83±14 kg, 174±6 cm) participated in seven testing sessions. The familiarization …
Relationship Between Muscular Performance Changes And Increases In Body Mass During Overfeeding Plus Resistance Training, Christian Rodriguez, Robert W. Smith, Matthew T. Stratton, Patrick S. Harty, Baylor A. Johnson, Jacob R. Dellinger, Marqui L. Benavides, Bradley Vincent, Abegale D. Williams, Sarah J. White, Grant M. Tinsley
Relationship Between Muscular Performance Changes And Increases In Body Mass During Overfeeding Plus Resistance Training, Christian Rodriguez, Robert W. Smith, Matthew T. Stratton, Patrick S. Harty, Baylor A. Johnson, Jacob R. Dellinger, Marqui L. Benavides, Bradley Vincent, Abegale D. Williams, Sarah J. White, Grant M. Tinsley
International Journal of Exercise Science: Conference Proceedings
Two critical components of muscular performance are muscular strength (e.g., the maximal load that can be lifted for a given exercise) and muscular endurance (e.g., the maximal number of repetitions that can be performed at a given load). When seeking improvements in muscular performance, it is common to employ nutritional strategies that create an energy surplus and a resultant gain in body mass. Varying rates of body mass gain are often prescribed to optimize training adaptations, including improvements in muscular performance; however, the relationship between rate of body mass gain and muscular performance improvements, if any, is not entirely clear. …
A Dietary Assessment Of Mid-Spectrum Chronic Kidney Disease, Kathleen E. Adair, Jeffrey S. Forsse, Matthew Peterson, Jeffery L. Heileson
A Dietary Assessment Of Mid-Spectrum Chronic Kidney Disease, Kathleen E. Adair, Jeffrey S. Forsse, Matthew Peterson, Jeffery L. Heileson
International Journal of Exercise Science: Conference Proceedings
Diets of adult individuals with mid-spectrum (stages III and IV) Chronic Kidney Disease (CKD) remain understudied. The 2015-2020 Dietary Guidelines for Americans food patterns based on the Recommended Dietary Allowances (RDA) in concert with the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI) guidelines are advised to individuals with CKD. Estimated glomerular filtration rate (eGFR) remains the best method for tracking CKD progression, yet relationships between self-reported dietary intake and eGFR are understudied. PURPOSE: To assess the self-reported dietary pattern in patients with stage III or IV CKD in contrast to the RDA and NKF KDOQI dietary guidelines …