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Inflammatory Response Following High-Intensity Interval Training (Hiit) Across Different Exercise Modalities: A Pilot Study, Bailey Mclagan, Jared Moore, George Salem
Inflammatory Response Following High-Intensity Interval Training (Hiit) Across Different Exercise Modalities: A Pilot Study, Bailey Mclagan, Jared Moore, George Salem
International Journal of Exercise Science: Conference Proceedings
Exercise-related muscular contractions produce and release numerous myokines, namely interleukins (IL) 6, 8, and 10. Most studies have focused on longer duration (>60 minutes) exercise and suggest that the IL-6 response to running is greater than that of cycling. However, to date, the effect of 4x4 High-Intensity Interval Training (HIIT) and modality on the inflammatory response to exercise have not been reported. PURPOSE: This pilot investigation characterized the inflammatory biomarker response to HIIT 4x4 running and cycling protocols. METHODS: Five young, recreationally active volunteers (1 female, 4 males; 27.20 ± 3.42 years) completed a heart rate max …
Stimulated Muscle Contractions Regulate Membrane-Bound And Soluble Tlr4 To Prevent Lps-Induced Signaling And Myotube Atrophy In Skeletal Muscle Cells, Jeremy B. Ducharme, Zachary J. Fennel, Zachary J. Mckenna, Quint N. Berkemeier, Michael R. Deyhle
Stimulated Muscle Contractions Regulate Membrane-Bound And Soluble Tlr4 To Prevent Lps-Induced Signaling And Myotube Atrophy In Skeletal Muscle Cells, Jeremy B. Ducharme, Zachary J. Fennel, Zachary J. Mckenna, Quint N. Berkemeier, Michael R. Deyhle
International Journal of Exercise Science: Conference Proceedings
Toll-like receptor 4 (TLR4) activation by lipopolysaccharides (LPS) contributes to chronic inflammation and causes upregulation of muscle atrophy signaling pathways. Exercise can suppress LPS/TLR4 axis activation by reducing the expression of TLR4 on immune cells. It is unknown how this regulation occurs, and it is not clear how exercise affects TLR4 on skeletal muscle. PURPOSE: To uncover the nature and mechanisms by which exercise affects TLR4 expression and intracellular signaling using cell culture models and human experiments. METHODS: C2C12 myotubes were subjected to electrical pulse stimulation (EPS) with and without subsequent treatment with 500 ng/mL lipopolysaccharide (LPS) along with …
Exercise Mobilizes Early And Late Differentiated Cd8 T Cells Expressing A Marker Of Exhaustion, Rebekah Hunt, Mahmoud Elzayat, Emily C. Lavoy
Exercise Mobilizes Early And Late Differentiated Cd8 T Cells Expressing A Marker Of Exhaustion, Rebekah Hunt, Mahmoud Elzayat, Emily C. Lavoy
International Journal of Exercise Science: Conference Proceedings
T cell differentiation occurs following activation of key functions, such as proliferation and cytokine production. Naïve (NA) and central memory (CM) T cells are early differentiated, whereas effector memory (EM) and RA+ effector memory cells (EMRA) are later differentiated. CD57 expression, a putative marker of exhaustion, has also been used to identify later differentiated cells, although recent data indicate CD57 can also be expressed by NA and CM. Exercise mobilizes EM and EMRA to a greater extent than NA and CM. Separately, exercise has been shown to preferentially mobilize CD57+ cells. Whether these exercise responsive CD57+ cells arise from highly …