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Disuse Atrophy Occurs Without A Change In Mitochondrial Respiratory Control Ratio During Hindlimb Unloading In Mice, Indu Reddy Enukonda, Megan E. Rosa-Caldwell, David E. Lee, Jacob L. Brown, Richard A. Perry, Tyrone A. Washington, Nicholas P. Greene, Michael P. Wiggs
Disuse Atrophy Occurs Without A Change In Mitochondrial Respiratory Control Ratio During Hindlimb Unloading In Mice, Indu Reddy Enukonda, Megan E. Rosa-Caldwell, David E. Lee, Jacob L. Brown, Richard A. Perry, Tyrone A. Washington, Nicholas P. Greene, Michael P. Wiggs
International Journal of Exercise Science: Conference Proceedings
Skeletal muscle atrophy commonly occurs during prolonged periods of inactivity, however, the precise mechanisms that cause muscle atrophy have yet to be determined. Specifically, a controversy exists on whether mitochondrial dysfunction is a cause or consequence of disuse muscle atrophy. PURPOSE: The purpose of this study was to determine if a change in the respiratory control ratio, which is a ratio of maximal O2 respiration to leak respiration, could be detected prior to muscle atrophy in a time-course study in mice. METHODS: Disuse atrophy was induced using hindlimb unloading (HU) in adult, C57BL/6J male mice for 0 …
Ubiquitin Proteasome System Activity Is Suppressed By Curcumin Following Exercise-Induced Muscle Damage In Human Skeletal Muscle, Thomas D. Cardaci, Steven B. Machek, Dylan T. Wilburn, Paul S. Hwang, Darryn Willoughby Phd
Ubiquitin Proteasome System Activity Is Suppressed By Curcumin Following Exercise-Induced Muscle Damage In Human Skeletal Muscle, Thomas D. Cardaci, Steven B. Machek, Dylan T. Wilburn, Paul S. Hwang, Darryn Willoughby Phd
International Journal of Exercise Science: Conference Proceedings
PURPOSE: Curcumin is a natural polyphenolic compound with antioxidant and anti-inflammatory properties. In vitro and in vivo animal studies have demonstrated that exposure to curcumin leads to dysregulation of the ubiquitin-proteasome system (UPS). However, to date, no study has investigated curcumin’s ability to influence UPS activity in a human model. Therefore, the purpose of this study was to investigate the effects of curcumin supplementation on markers of UPS activity in the presence of elevations in UPS activity due to exercise-induced muscle damage. METHODS: Twenty-three recreationally active male and female participants between the ages of 18-30 were randomized into …
A Wearable Garment To Mitigate Low Back Pain In Astronauts, Curtis Neeld, Miranda Moore, Alexis Quintana, Audra Romans, Arianne Scheller, Charles Swieczkowski, Nicholas A. Levine, Brandon R. Rigby
A Wearable Garment To Mitigate Low Back Pain In Astronauts, Curtis Neeld, Miranda Moore, Alexis Quintana, Audra Romans, Arianne Scheller, Charles Swieczkowski, Nicholas A. Levine, Brandon R. Rigby
International Journal of Exercise Science: Conference Proceedings
The microgravity environment of space is known to cause a wide array of adverse physiological effects on the bodies of astronauts. Among these effects, low back pain due to space adaptation is commonly reported by astronauts. In fact, this pain, caused primarily by atrophy of the erector spinae musculature, has the highest incidence rate among all musculoskeletal-related conditions reported by this population while in space. Low back pain and the consequences of other medical conditions may become magnified as the duration of missions increases over the next few decades. Therefore, determining methods of preventing and mitigating the deleterious effects of …