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Resistance Exercise Elicits Selective Mobilization And Adhesion Characteristics Of Granulocytes And Monocyte Subsets, Adam Jajtner Jan 2016

Resistance Exercise Elicits Selective Mobilization And Adhesion Characteristics Of Granulocytes And Monocyte Subsets, Adam Jajtner

Electronic Theses and Dissertations

Resistance exercise eliciting muscle damage results in an immune response, leading to increases in circulating cytokines, and immune cell mobilization. Classical monocytes respond to muscle damage, however, little is known about the intermediate or nonclassical monocyte response to resistance exercise. Moreover, the impact of polyphenol supplementation in conjunction with resistance exercise on the innate immune response is unknown. The purpose of this study was to examine the immune response following resistance exercise with (PPB) and without (PL) polyphenol supplementation. Thirty-nine untrained men were randomized into three groups: PPB (n=13, 21.8±2.5yrs, 171.2±5.5cm, 71.2±8.2kg), PL (n=15, 21.6±2.5yrs, 176.5±4.9cm, 84.0±15.7kg) or a control …


Intramuscular Tnf-Alpha Signaling In Response To Resistance Exercise And Recovery In Untrained Males., Jeremy Townsend Jan 2016

Intramuscular Tnf-Alpha Signaling In Response To Resistance Exercise And Recovery In Untrained Males., Jeremy Townsend

Electronic Theses and Dissertations

INTRODUCTION: The nuclear factor kappa B (NF-κβ) signaling cascade is responsible for mediating stress-activated catabolic effects of Tumor Necrosis Factor Alpha (TNF-α) downstream of the TNF receptor (TNFR1). NF-κβ transcription factor remains inhibited in the cytosol of the muscle and can be stimulated for translocation and transcription by a variety of external stimuli, most notably by pro-inflammatory cytokines and oxidative stress. Nevertheless, currently there is a gap in the literature with regard to the time course effect of NF-κβ signaling following acute resistance exercise in humans. PURPOSE: To observe the effects of an acute lower-body resistance exercise protocol and subsequent …


Acute Pro-Inflammatory Immune Response Following Different Resistance Exercise Protocols In Trained Men, Adam Wells Jan 2015

Acute Pro-Inflammatory Immune Response Following Different Resistance Exercise Protocols In Trained Men, Adam Wells

Electronic Theses and Dissertations

The successful regeneration of muscle tissue is dependent upon the infiltration of phagocytic CD14++CD16- monocytes that support the proliferation and differentiation of myogenic precursor cells. Physiologically, the magnitude of the cellular response following resistance exercise is dictated by the level of receptor expression on the plasma membrane of the monocyte, as well as the secretion of their cognate ligands from tissue resident cells. However, it remains unclear whether the innate pro-inflammatory immune response varies with different resistance training protocols, and how it may impact recovery and the muscle remodeling process. Therefore, the purpose of this investigation was to examine temporal …


Intramuscular Anabolic Signaling And Endocrine Response Following Different Resistance Exercise Protocols In Trained Men, Adam Gonzalez Jan 2015

Intramuscular Anabolic Signaling And Endocrine Response Following Different Resistance Exercise Protocols In Trained Men, Adam Gonzalez

Electronic Theses and Dissertations

The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway appears to be the primary regulator of protein synthesis and growth. While resistance exercise paradigms are often divided into hypertrophy (HYP) and strength (STR) protocols, it is unknown whether these protocols differentially stimulate mTORC1 signaling. The purpose of this study was to examine mTORC1 signaling in conjunction with circulating hormone concentrations following a typical lower-body HYP and STR resistance exercise protocol. Ten resistance-trained men (24.7±3.4y; 90.1±11.3kg; 176.0±4.9cm) performed each resistance exercise protocol in a random, counterbalanced order. Blood samples were obtained at baseline (BL), immediately (IP), 30 minutes (30P), 1 …


The Effect Of Training Volume And Intensity On Improvements In Muscular Strength And Size In Resistance-Trained Men, Gerald Mangine Jan 2015

The Effect Of Training Volume And Intensity On Improvements In Muscular Strength And Size In Resistance-Trained Men, Gerald Mangine

Electronic Theses and Dissertations

The magnitude of improvements in muscular strength and size are influenced by the volume and intensity of a resistance training program. While it is clearly advantageous for resistance-trained individuals to utilize programming specific to these goals, it not clear which is more important. Therefore the purpose of the present investigation was to determine the effect of focusing on training volume versus intensity on changes in muscle size and strength. Changes in muscular strength and size were examined in 29 resistance-trained men following 8 weeks of resistance training. Participants were randomly assigned to either a high volume (VOL, n = 14, …