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Size Of Food Bowl And Scoop Affects Amount Of Food Owners Feed Their Dogs, M Murphy, A Lusby, J Bartges, Claudia Kirk Dec 2011

Size Of Food Bowl And Scoop Affects Amount Of Food Owners Feed Their Dogs, M Murphy, A Lusby, J Bartges, Claudia Kirk

Claudia A Kirk

The incidence of canine obesity appears to be increasing dramatically and understanding factors impacting the amount of food pet owners provide their dogs may improve weight management. Human research has shown the size of food bowls, plates and utensils can significantly impact the amount of food portioned and consumed. This effect can be attributed to both the Delboeuf optical illusion and the Ebbinghaus-Titchener size-contrast illusion. To investigate the existence of a similar effect with dog owners, 54 dogs and their owners were recruited for a four treatment randomized prospective trial. Owners scooped out a normal kibble-based meal using a small ...


Effects Of Early Experience On Food Acceptance In A Colony Of Adult Research Cats: A Preliminary Study, B Hamper, B Rohrbach, Claudia Kirk, Angela Lusby, Joe Bartges Dec 2011

Effects Of Early Experience On Food Acceptance In A Colony Of Adult Research Cats: A Preliminary Study, B Hamper, B Rohrbach, Claudia Kirk, Angela Lusby, Joe Bartges

Claudia A Kirk

Acceptance of feline commercial canned and raw-type moist foods was evaluated in 18 adult cats with and without dietary pre-exposure to the same moist foods in the postweaning period. We hypothesized that cats pre-exposed to moist foods would readily accept canned or raw foods on re-exposure as adults, despite consuming a commercial expanded dry food for a period of 7-23 months. A total of 13 cats were fed 1 of 3 moist foods (commercial canned, commercial raw, or homemade raw foods) exclusively between 9 and 20 weeks of age (exposed), and 5 adult cats were offered only dry food during ...


Size Of Food Bowl And Scoop Affects Amount Of Food Owners Feed Their Dogs, Maryanne Murphy, Angela Witzel, Joe Bartges, Claudia Kirk Dec 2010

Size Of Food Bowl And Scoop Affects Amount Of Food Owners Feed Their Dogs, Maryanne Murphy, Angela Witzel, Joe Bartges, Claudia Kirk

Claudia A Kirk

The incidence of canine obesity appears to be increasing dramatically and understanding factors impacting the amount of food pet owners provide their dogs may improve weight management. Human research has shown the size of food bowls, plates and utensils can significantly impact the amount of food portioned and consumed. This effect can be attributed to both the Delboeuf optical illusion and the Ebbinghaus-Titchener size-contrast illusion. To investigate the existence of a similar effect with dog owners, 54 dogs and their owners were recruited for a four treatment randomized prospective trial. Owners scooped out a normal kibble-based meal using a small ...


Comparison Of A Human Portable Blood Glucose Meter, Veterinary Portable Blood Glucose Meter, And Automated Chemistry Analyzer For Measurement Of Blood Glucose Concentrations In Dogs, Beth Johnson, Michael Fry, Bente Flatland, Claudia Kirk Nov 2009

Comparison Of A Human Portable Blood Glucose Meter, Veterinary Portable Blood Glucose Meter, And Automated Chemistry Analyzer For Measurement Of Blood Glucose Concentrations In Dogs, Beth Johnson, Michael Fry, Bente Flatland, Claudia Kirk

Claudia A Kirk

OBJECTIVE: To compare blood glucose concentrations measured with 2 portable blood glucose meters (PBGMs) validated for use in dogs (PBGM-D) and humans (PBGM-H) and an automated chemistry analyzer. DESIGN: Validation study. SAMPLE POPULATION: 92 samples of fresh whole blood and plasma from 83 dogs with various diseases. PROCEDURES: Each PBGM was used to measure whole blood glucose concentration, and the automated analyzer was used to measure plasma glucose concentration. Passing-Bablok linear regression and Bland-Altman plots were used to determine correlations and bias between the PBGMs and the automated analyzer. Calculated acceptability limits based on combined inherent instrument imprecision were used ...


The Role Of Key Adipokines In Obesity And Insulin Resistance In Cats, Angela Lusby, Claudia Kirk, Joe Bartges Aug 2009

The Role Of Key Adipokines In Obesity And Insulin Resistance In Cats, Angela Lusby, Claudia Kirk, Joe Bartges

Claudia A Kirk

No abstract provided.


Changes In Hepatic Gene Expression In Dogs With Experimentally Induced Nutritional Iron Deficiency, Michael Fry, Claudia Kirk, Jason Liggett, Gregory Daniel, Seung Baek, Julia Gouffon, P Chimakurthy, B Rekapalli Dec 2008

Changes In Hepatic Gene Expression In Dogs With Experimentally Induced Nutritional Iron Deficiency, Michael Fry, Claudia Kirk, Jason Liggett, Gregory Daniel, Seung Baek, Julia Gouffon, P Chimakurthy, B Rekapalli

Claudia A Kirk

BACKGROUND AND OBJECTIVE: We investigated hepatic gene expression in dogs with experimentally induced nutritional iron deficiency (ID). Our hypothesis was that ID would result in decreased hepcidin gene expression, and possibly in altered expression of other genes associated with iron metabolism. METHODS: Liver biopsies were collected from each of 3 dogs before induction of ID, at the point of maximal ID, and after resolution of ID. Using Affymetrix microarray technology and analytical tools specifically designed for microarray data, we identified genes that had at least a 2-fold change in expression in response to ID. Four genes were selected for further ...


Influence Of Dirlotapide, A Microsomal Triglyceride Transfer Protein Inhibitor, On The Digestibility Of A Dry Expanded Diet In Adult Dogs, Claudia Kirk Jul 2007

Influence Of Dirlotapide, A Microsomal Triglyceride Transfer Protein Inhibitor, On The Digestibility Of A Dry Expanded Diet In Adult Dogs, Claudia Kirk

Claudia A Kirk

The objectives of this study were to evaluate the effects of dirlotapide, a microsomal triglyceride transfer protein inhibitor, on apparent nutrient digestibility of an expanded dry dog food, on defecation frequency and fecal consistency. Eighteen beagles were randomized to either placebo (n = 6) or dirlotapide (n = 12). Testing was divided into a 21-day adaptation phase (days -21 to -1) and a 35-day treatment (digestibility testing) phase (days 0-35). During the treatment phase, dogs were administered oral dirlotapide (0.3 mg/kg) or placebo (0.06 mL/kg) once daily. For digestibility testing, feces were collected over two periods for 7 ...


A Canine Aflatoxicosis Outbreak And Guidelines For Handling Commercial Dog Food Contaminations, J Smith, Katherine Stenske, Shelley Newman, Claudia Kirk Mar 2007

A Canine Aflatoxicosis Outbreak And Guidelines For Handling Commercial Dog Food Contaminations, J Smith, Katherine Stenske, Shelley Newman, Claudia Kirk

Claudia A Kirk

No abstract provided.


Influence Of Hydrochlorothiazide On Urinary Calcium Oxalate Relative Supersaturation In Healthy Young Adult Female Domestic Shorthaired Cat, A Hezel, Joe Bartges, Claudia Kirk, Sherry Cox, N Geyer, T Moyers, J Hayes Dec 2006

Influence Of Hydrochlorothiazide On Urinary Calcium Oxalate Relative Supersaturation In Healthy Young Adult Female Domestic Shorthaired Cat, A Hezel, Joe Bartges, Claudia Kirk, Sherry Cox, N Geyer, T Moyers, J Hayes

Claudia A Kirk

Hydrochlorothiazide (1 mg/kg PO q12h) or placebo was administered to healthy cats for 2 weeks in a masked, placebo-controlled, crossover-design study, and 24-hour urine samples were collected. When cats received hydrochlorothiazide, 24-hour urine volume, ammonia, chloride, creatinine, magnesium, oxalic acid, phosphate, potassium, and sodium were significantly higher than when cats received placebo. Hydrochlorothiazide was associated with significantly lower urinary saturation for calcium oxalate, but no difference was found in 24-hour urine calcium and citrate, urinary saturation for struvite, or blood ionized calcium. Hydrochlorothiazide decreased urinary saturation for calcium oxalate and could be useful in managing cats with calcium oxalate ...


Influence Of Prednisolone On Urinary Calcium Oxalate And Struvite Relative Supersaturation In Healthy Young Adult Female Domestic Shorthaired Cats, N Geyer, Joe Bartges, Claudia Kirk, Sherry Cox, A Hezel, T Moyers, J Hayes Dec 2006

Influence Of Prednisolone On Urinary Calcium Oxalate And Struvite Relative Supersaturation In Healthy Young Adult Female Domestic Shorthaired Cats, N Geyer, Joe Bartges, Claudia Kirk, Sherry Cox, A Hezel, T Moyers, J Hayes

Claudia A Kirk

Prednisolone (10 mg PO q24h) or placebo was administered to healthy cats for 2 weeks in a masked, placebo-controlled, crossover-design study, and 24-hour urine samples were collected. When cats received prednisolone, 24-hour urine pH was lower and 24-hour urine excretion of creatinine, magnesium, phosphate, and potassium was higher than when cats received placebo. No significant difference was found in urinary relative supersaturation for calcium oxalate (CaOx) or struvite between treatment groups. Prednisolone administration did not induce diuresis, nor was it associated with increased calcium excretion or urinary saturation for CaOx in these healthy cats. Results of this study, however, should ...


Clinical Evaluation Of Dietary Modification For Treatment Of Spontaneous Chronic Kidney Disease In Cats, S Ross, C Osborne, Claudia Kirk, S Lowry, L Koehler, D Polzin Sep 2006

Clinical Evaluation Of Dietary Modification For Treatment Of Spontaneous Chronic Kidney Disease In Cats, S Ross, C Osborne, Claudia Kirk, S Lowry, L Koehler, D Polzin

Claudia A Kirk

Objective-To determine whether a renal diet modified in protein, phosphorus, sodium, and lipid content was superior to an adult maintenance diet in minimizing uremic episodes and mortality rate in cats with stage 2 or 3 chronic kidney disease (CKD). Design-Double-masked, randomized, controlled clinical trial. Animals-45 client-owned cats with spontaneous stage 2 or 3 CKD. Procedures-Cats were randomly assigned to an adult maintenance diet (n = 23 cats) or a renal diet (22) and evaluated trimonthly for up to 24 months. Efficacy of the renal diet, compared with the maintenance diet, in minimizing uremia, renal-related deaths, and all causes of death was ...


Reticulocyte Indices In A Canine Model Of Nutritional Iron Deficiency, Michael Fry, Claudia Kirk May 2006

Reticulocyte Indices In A Canine Model Of Nutritional Iron Deficiency, Michael Fry, Claudia Kirk

Claudia A Kirk

BACKGROUND: Reticulocyte indices, especially reticulocyte hemoglobin content (CH retic), have shown promise as markers of iron deficiency (ID), but there have been no prospective investigations of reticulocyte indices in experimental models of ID. OBJECTIVES: The objective of this study was to compare reticulocyte indices with conventional hematologic and biochemical indices as markers of ID in dogs. METHODS: Iron deficiency was induced in 7 dogs by feeding an iron-deficient diet, and corrected by restoring dietary iron and by giving iron parenterally. Blood samples were collected at weekly intervals. Results of hematologic and biochemical tests were compared using t-tests and receiver operator ...


Comparison Of A Low Carbohydrate-Low Fiber Diet And A Moderate Carbohydrate-High Fiber Diet In The Management Of Feline Diabetes Mellitus, N Bennett, D Greco, M Peterson, Claudia Kirk, M Mathes, M Fettman Mar 2006

Comparison Of A Low Carbohydrate-Low Fiber Diet And A Moderate Carbohydrate-High Fiber Diet In The Management Of Feline Diabetes Mellitus, N Bennett, D Greco, M Peterson, Claudia Kirk, M Mathes, M Fettman

Claudia A Kirk

This study compared the effects of a moderate carbohydrate-high fiber (MC-HF) food and a low carbohydrate-low fiber (LC-LF) food on glycemic control in cats with diabetes mellitus. Sixty-three diabetic cats (48 male castrated, 15 female spayed) were randomly assigned to be fed either a canned MC-HF (n = 32) food or a canned LC-LF (n = 31) food for 16 weeks. Owners were blinded to the type of diet fed. CBC, urinalysis, serum chemistry panel, fructosamine concentration and thyroxine concentration were determined on initial examination, and a complete blood count, serum chemistry panel, urinalysis and serum fructosamine concentration were repeated every 4 ...


Primary Hair Growth In Dogs Depends On Dietary Selenium Concentrations, S Yu, K Wedekind, Claudia Kirk, R Nachreiner Mar 2006

Primary Hair Growth In Dogs Depends On Dietary Selenium Concentrations, S Yu, K Wedekind, Claudia Kirk, R Nachreiner

Claudia A Kirk

Selenium (Se) plays an important role in hair growth. The objective of this study was to investigate the effect of dietary selenium concentration on hair growth in dogs. Thirty-six beagles were stratified into six groups based on age, gender and body condition score. The dogs were fed a torula yeast-based canned food for 3 weeks. Then the dogs were fed varying amounts of selenium supplied as selenomethionine for an additional 24 weeks. Analysed selenium concentrations in the experimental foods for the six groups were 0.04, 0.09, 0.12, 0.54, 1.03 and 5.04 mg/kg dry ...


Prevalence And Risk Factors For Obesity In Adult Dogs From Private Us Veterinary Practices, E Lund, P Armstrong, Claudia Kirk, J Klausner Dec 2005

Prevalence And Risk Factors For Obesity In Adult Dogs From Private Us Veterinary Practices, E Lund, P Armstrong, Claudia Kirk, J Klausner

Claudia A Kirk

Using a cross-sectional study design, the prevalence of overweight and obesity in dogs over 1 year of age seen by US veterinarians during 1995 was determined. Risk factors for overweight and obesity were also determined from the following variables: age, breed, gender, body condition score, food type, reported concurrent disease, and geographic region. Thirty-four percent of adult dogs (n=21,754) were overweight or obese. From multivariate analyses, overweight dogs were more likely to be older, of certain breeds (Cocker Spaniel, Labrador Retriever, Dalmatian, Dachshund, Rottweiler, Golden Retriever, Shetland Sheepdog, Mixed-breed), neutered, and to consume a semi-moist food as their ...


Effects Of Sodium Chloride On Selected Parameters In Cats, Claudia Kirk, D Jewell, S Lowry Dec 2005

Effects Of Sodium Chloride On Selected Parameters In Cats, Claudia Kirk, D Jewell, S Lowry

Claudia A Kirk

This study used 36 cats with varying renal insufficiency and physiologic status to evaluate the effect of a food high in sodium chloride (HSC) compared with a low sodium chloride (LSC) food on selected blood parameters and blood pressure. Cats eating the HSC food had an increase in serum creatinine, urea nitrogen, and phosphorus compared with cats eating the LSC food. Also, cats eating the HSC food had increased fractional excretion of calcium and increased fractional shortening during cardiac contraction. There was no effect of food on systolic, diastolic, or mean arterial pressure.


Post Treatment Skeletal Mineral Accretion In Malnourished, Growing Animals, Susan Lauten, Joe Bartges, Claudia Kirk, E Klaphake Nov 2005

Post Treatment Skeletal Mineral Accretion In Malnourished, Growing Animals, Susan Lauten, Joe Bartges, Claudia Kirk, E Klaphake

Claudia A Kirk

No abstract provided.


Evaluation Of The Association Between Initial Proteinuria And Morbidity Rate Or Death In Dogs With Naturally Occurring Chronic Renal Failure, F Jacob, D Polzin, C Osborne, J Neaton, Claudia Kirk, T Allen, L Swanson Jan 2005

Evaluation Of The Association Between Initial Proteinuria And Morbidity Rate Or Death In Dogs With Naturally Occurring Chronic Renal Failure, F Jacob, D Polzin, C Osborne, J Neaton, Claudia Kirk, T Allen, L Swanson

Claudia A Kirk

OBJECTIVE: To determine whether urine protein-to-creatinine ratio (UP:C) > or = 1.0 at initial diagnosis of chronic renal failure (CRF) is associated with greater risk of development of uremic crises, death, and progression of renal failure in dogs. DESIGN: Prospective cohort study. ANIMALS: 45 dogs with CRF PROCEDURE: Dogs were prospectively assigned to 2 groups on the basis of initial UP:C < 1.0 or 2 > or = 1.0. The association between magnitude of proteinuria and development of uremic crises and death was determined before and after dogs with initial UP:C > or =1.0 were assigned to 3 subgroups and compared with dogs ...


Prevalence And Risk Factors For Obesity In Adult Cats From Private Us Veterinary Practices., E Lund, P Armstrong, Claudia Kirk, J Klausner Dec 2004

Prevalence And Risk Factors For Obesity In Adult Cats From Private Us Veterinary Practices., E Lund, P Armstrong, Claudia Kirk, J Klausner

Claudia A Kirk

Using a cross-sectional study design, the prevalence of overweight and obesity in adult cats seen by US veterinarians during 1995 was determined. Risk factors for overweight and obesity were also determined from the following variables: age, breed, gender, body condition score, food type, reported concurrent disease, and geographic region. Thirty-five percent of adult cats (n=8,159) were overweight or obese. From multivariate analyses, overweight cats were more likely to be neutered, male, eating a premium or therapeutic food, and to be concurrently diagnosed with disease of the oral cavity or urinary tract. Obese cats were more likely to be ...


Thyroid To Salivary Ratios Determined By Technetium-99m Pertechnetate Imaging In Thirty-Two Euthyroid Cats, T Henrikson, L Armbrust, J Hoskinson, G Milliken, K Wedekind, Claudia Kirk, R Nachreiner Dec 2004

Thyroid To Salivary Ratios Determined By Technetium-99m Pertechnetate Imaging In Thirty-Two Euthyroid Cats, T Henrikson, L Armbrust, J Hoskinson, G Milliken, K Wedekind, Claudia Kirk, R Nachreiner

Claudia A Kirk

Thyroid to salivary (TS) ratio is the most commonly used scintigraphic parameter for differentiating euthyroid and hyperthyroid cats. Studies to determine the normal TS ratio have been performed in small cat populations. In this study, the TS ratio was determined in 32 cats between 8 and 13 years of age. The study population was documented to be euthyroid based on normal initial and 6-week follow-up serum thyroid concentrations and normal T3 suppression tests. All images were obtained with a low-energy all-purpose collimator between 20 and 40 min after the injection of approximately 111 MBq (3.0 mCi) pertechnetate. Manual regions ...


Effects Of Diet On Urine Composition Of Cats With Calcium Oxalate Urolithiasis, J Lulich, C Osborne, Claudia Kirk, C Lekcharoensuk, Joe Bartges Dec 2003

Effects Of Diet On Urine Composition Of Cats With Calcium Oxalate Urolithiasis, J Lulich, C Osborne, Claudia Kirk, C Lekcharoensuk, Joe Bartges

Claudia A Kirk

Ten client-owned cats with calcium oxalate (CaOx) urolithiasis were evaluated to determine the effect of diet on urine CaOx saturation. Two dietary treatments were evaluated in each cat: the diet consumed just prior to urolith detection and a canned diet formulated to prevent CaOx uroliths. This study revealed that hypercalciuria is a consistent abnormality in cats with CaOx urolith formation. When urolith-forming cats consumed a diet formulated to prevent urolith formation, activity product ratios for CaOx (which estimate the degree to which urine is saturated with CaOx) were significantly lower. These results suggest that consumption of an appropriately formulated urolith-prevention ...


Association Between Initial Systolic Blood Pressure And Risk Of Developing A Uremic Crisis Or Of Dying In Dogs With Chronic Renal Failure, F Jacob, D Polzin, C Osborne, J Neaton, C Lekcharoensuk, T Allen, Claudia Kirk, L Swanson Jan 2003

Association Between Initial Systolic Blood Pressure And Risk Of Developing A Uremic Crisis Or Of Dying In Dogs With Chronic Renal Failure, F Jacob, D Polzin, C Osborne, J Neaton, C Lekcharoensuk, T Allen, Claudia Kirk, L Swanson

Claudia A Kirk

OBJECTIVE: To determine whether high systolic blood pressure (SBP) at the time of initial diagnosis of chronic renal failure in dogs was associated with increased risk of uremic crisis, risk of dying, or rate of decline in renal function. DESIGN: Prospective cohort study. ANIMALS: 45 dogs with spontaneous chronic renal failure. PROCEDURE: Dogs were assigned to 1 of 3 groups on the basis of initial SBP (high, intermediate, low); Kaplan-Meier and Cox proportional hazards methods were used to estimate the association between SBP and development of a uremic crisis and death. The reciprocal of serum creatinine concentration was used as ...


Clinical Guidelines For Managing Calcium Oxalate Uroliths In Cats: Diagnosis, Urolith Removal, And Monitoring, Claudia Kirk, G Ling, C Osborne, B Novotny Dec 2002

Clinical Guidelines For Managing Calcium Oxalate Uroliths In Cats: Diagnosis, Urolith Removal, And Monitoring, Claudia Kirk, G Ling, C Osborne, B Novotny

Claudia A Kirk

No abstract provided.


Clinical Guidelines For Managing Calcium Oxalate Uroliths In Cats: Medical Therapy, Hydration, And Dietary Therapy, Claudia Kirk, G Ling, C Osborne, B Novotny Dec 2002

Clinical Guidelines For Managing Calcium Oxalate Uroliths In Cats: Medical Therapy, Hydration, And Dietary Therapy, Claudia Kirk, G Ling, C Osborne, B Novotny

Claudia A Kirk

This article covers the effective monitoring and treatment protocols for the management of a cat with recurrent calcium oxalate urolithiasis, wherein an treatment approach is preferred. The evidence that supports interventions in medical therapy, hydration and dietary therapy are discussed.


Clinical Evaluation Of Dietary Modification For Treatment Of Spontaneous Chronic Renal Failure In Dogs, F Jacob, D Polzin, C Osborne, T Allen, Claudia Kirk, J Neaton, C Lekcharoensuk, L Swanson Apr 2002

Clinical Evaluation Of Dietary Modification For Treatment Of Spontaneous Chronic Renal Failure In Dogs, F Jacob, D Polzin, C Osborne, T Allen, Claudia Kirk, J Neaton, C Lekcharoensuk, L Swanson

Claudia A Kirk

OBJECTIVE: To determine whether a diet used for dogs with renal failure (renal food [RF]) was superior to an adult maintenance food (MF) in minimizing uremic crises and mortality rate in dogs with spontaneous chronic renal failure. DESIGN: Double-masked, randomized, controlled clinical trial. ANIMALS: 38 dogs with spontaneous chronic renal failure. PROCEDURE: Dogs were randomly assigned to a group fed adult MF or a group fed RF and evaluated for up to 24 months. The 2 groups were of similar clinical, biochemical, and hematologic status. The effects of diets on uremic crises and mortality rate were compared. Changes in renal ...


Associations Between Dry Dietary Factors And Canine Calcium Oxalate Uroliths, C Lekcharoensuk, C Osborne, J Lulich, R Pusoonthornthum, Claudia Kirk, L Ulrich, L Koehler, K Carpenter, L Swanson Feb 2002

Associations Between Dry Dietary Factors And Canine Calcium Oxalate Uroliths, C Lekcharoensuk, C Osborne, J Lulich, R Pusoonthornthum, Claudia Kirk, L Ulrich, L Koehler, K Carpenter, L Swanson

Claudia A Kirk

OBJECTIVE: To identify factors in dry diets associated with the occurrence of calcium oxalate (CaOx) uroliths in dogs. ANIMALS: 600 dogs with CaOx uroliths and 898 dogs without urinary tract diseases. PROCEDURE: Univariate and multivariate logistic regression were performed. RESULTS: Compared with diets with the highest concentrations of sodium, dry diets with the lowest concentrations of sodium, phosphorus, calcium, chloride, protein, magnesium, or potassium were linearly associated with increased risk of CaOx urolith formation. Significant nonlinear associations between increased occurrence of CaOx uroliths and urine acidifying potential and low moisture content were observed. Significant nonlinear associations between decreased occurrence of ...


Association Between Dietary Factors And Calcium Oxalate And Magnesium Ammonium Phosphate Urolithiasis In Cats, C Lekcharoensuk, C Osborne, J Lulich, R Pusoonthornthum, Claudia Kirk, L Ulrich, L Koehler, K Carpenter, L Swanson Oct 2001

Association Between Dietary Factors And Calcium Oxalate And Magnesium Ammonium Phosphate Urolithiasis In Cats, C Lekcharoensuk, C Osborne, J Lulich, R Pusoonthornthum, Claudia Kirk, L Ulrich, L Koehler, K Carpenter, L Swanson

Claudia A Kirk

OBJECTIVE: To identify dietary factors associated with the increase in occurrence of calcium oxalate (CaOx) uroliths and the decrease in occurrence of magnesium ammonium phosphate (MAP) uroliths in cats. DESIGN: Case-control study. ANIMALS: 173 cats with CaOx uroliths, 290 cats with MAP uroliths, and 827 cats without any urinary tract diseases. PROCEDURE: Univariate and multivariate logistic regression were performed. RESULTS: Cats fed diets low in sodium or potassium or formulated to maximize urine acidity had an increased risk of developing CaOx uroliths but a decreased risk of developing MAP uroliths. Additionally, compared with the lowest contents, diets with the highest ...


Effects Of Hydrochlorothiazide And Diet In Dogs With Calcium Oxalate Urolithiasis, J Lulich, C Osborne, C Lekcharoensuk, Claudia Kirk, T Allen May 2001

Effects Of Hydrochlorothiazide And Diet In Dogs With Calcium Oxalate Urolithiasis, J Lulich, C Osborne, C Lekcharoensuk, Claudia Kirk, T Allen

Claudia A Kirk

OBJECTIVE: To determine whether hydrochlorothiazide (HCTZ) reduces urinary calcium excretion in dogs with calcium oxalate urolithiasis. DESIGN: Original study. ANIMALS: 8 dogs with calcium oxalate urolithiasis. PROCEDURE: 4 treatment protocols were evaluated in each dog (a low calcium, low protein diet designed to prevent calcium oxalate urolith formation with and without administration of HCTZ [2 mg/kg (0.9 mg/lb) of body weight, PO, q 12 h] and a maintenance diet with higher quantities of protein and calcium with and without administration of HCTZ). At the end of each 2-week treatment period, 24-hour urine samples were collected. Blood samples ...


Oral Chromium Picolinate And Control Of Glycemia In Insulin-Treated Diabetic Dogs, Claudia Kirk, S Schachter, R Nelson Dec 2000

Oral Chromium Picolinate And Control Of Glycemia In Insulin-Treated Diabetic Dogs, Claudia Kirk, S Schachter, R Nelson

Claudia A Kirk

Chromium is an essential dietary trace mineral involved in carbohydrate and lipid metabolism. Chromium is required for cellular uptake of glucose, and chromium deficiency causes insulin resistance. Chromium supplementation may improve insulin sensitivity and has been used as adjunct treatment of diabetes mellitus in humans. In this study, 13 dogs with naturally acquired diabetes mellitus were treated with insulin for 3 months, then with insulin and chromium picolinate for 3 months. Dogs weighing <15 kg (33 lb: n = 9) were administered 200 microg of chromium picolinate PO once daily for I month, then 200 microg of chromium picolinate twice daily for 2 months. Dogs weighing >15 kg (n = 4) received 200 microg of chromium picolinate once daily for 2 weeks, then 200 microg twice daily for 2 weeks, then 400 microg twice ...


Hepatotoxicity Of Stanozolol In Cats., K Harkin, L Cowan, G Andrews, R Basaraba, J Fischer, L Debowes, J Roush, M Guglielmino, Claudia Kirk Aug 2000

Hepatotoxicity Of Stanozolol In Cats., K Harkin, L Cowan, G Andrews, R Basaraba, J Fischer, L Debowes, J Roush, M Guglielmino, Claudia Kirk

Claudia A Kirk

OBJECTIVE: To determine hepatotoxicity of stanozolol in cats and to identify clinicopathologic and histopathologic abnormalities in cats with stanozolol-induced hepatotoxicosis. DESIGN: Clinical trial and case series. ANIMALS: 12 healthy cats, 6 cats with chronic renal failure, and 3 cats with gingivitis and stomatitis. PROCEDURES: Healthy cats and cats with renal failure were treated with stanozolol (25 mg, i.m., on the first day, then 2 mg, p.o., q 12 h) for 4 weeks. Cats with gingivitis were treated with stanozolol at a dosage of 1 mg, p.o., every 24 hours. RESULTS: Most healthy cats and cats with renal ...