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Trpv1 Channels In Human Skeletal Muscle Feed Arteries: Implications For Vascular Function, Stephen J. Ives, Song-Young Park, Oh-Sung Kwon, Jayson R. Gifford, Robert H. I. Andtbacka, John R. Hyngstrom, Russell S. Richardson

Health and Kinesiology Faculty Publications

New Findings

• What is the central question of this study?

  We sought to determine whether human skeletal muscle feed arteries (SFMAs) express TRPV1 channels and what role they play in modulating vascular function.

• What is the main finding and its importance?

  Human SMFAs do express functional TRPV1 channels that modulate vascular function, specifically opposing α-adrenergic receptor-mediated vasocontraction and potentiating vasorelaxation, in an endothelium-dependent manner, as evidenced by the α1-receptor-mediated responses. Thus, the vasodilatory role of TRPV1 channels, and their ligand capsaicin, could be a potential therapeutic target for improving vascular function. Additionally, given the ‘sympatholytic’ effect of TRPV1 activation and …

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Α1- And Α2-Adrenergic Responsiveness In Human Skeletal Muscle Feed Arteries: The Role Of Trpv Ion Channels In Heat-Induced Sympatholysis, J. R. Gifford, S. J. Ives, Song-Young Park, R. H. I. Andtbacka, John R. Hyngstrom, Michelle T. Mueller, Gerald S. Treinman, Christopher Ward, Joel D. Trinity, Russell S. Richardson

Health and Kinesiology Faculty Publications

The purpose of this study was to determine if heat inhibits α2-adrenergic vasocontraction, similarly to α1-adrenergic contraction, in isolated human skeletal muscle feed arteries (SMFA) and elucidate the role of the temperature-sensitive vanilloid-type transient receptor potential (TRPV) ion channels in this response. Isolated SMFA from 37 subjects were studied using wire myography. α1 [Phenylephrine (PE)]- and α2 [dexmedetomidine (DEX)]-contractions were induced at 37 and 39°C with and without TRPV family and TRPV4-specific inhibition [ruthenium red (RR) and RN-1734, respectively]. Endothelial function [acetylcholine (ACh)] and smooth muscle function [sodium nitroprusside (SNP) and potassium chloride (KCl)] were also assessed under these conditions. …

G05-1582 How To Reduce Heat Stress In Dairy Cattle, Jeffrey F. Keown, Paul J. Kononoff, Richard J. Grant

University of Nebraska-Lincoln Extension: Historical Materials

Four ways to reduce heat stress and maintain production and fertility in dairy cattle.

Heat stress is one of the leading causes of decreased production and fertility in Nebrasks dairy cattle during summer months. These losses are apparent in the decreased amount of milk shipped, increased days open and decreased breedings per conception. Some heat stress is unavoidable, but effects can be minimized if certain management practices are followed.

Nf04-605 Smoking Meat And Poultry, Julie A. Albrecht

University of Nebraska-Lincoln Extension: Historical Materials

Where there's smoke, there's well-flavored meat and poultry. Using a smoker is one method of imparting natural smoke flavor to large cuts of meat, whole poultry and turkey breasts. This slow cooking technique keeps them tender, too.

Smoking is slowly cooking food indirectly in the presence of a fire. This can be done by using a "smoker," which is an outdoor cooker especially designed for this purpose. Use these simple guidelines for smoking food safely.

Ec02-105 Nebraska Corn Hybrid Tests, 2002, Lenis Alton Nelson, Robert N. Klein, Roger Wesley Elmore, David D. Baltensperger, Charles A. Shapiro, Stevan Z. Knezevic, James Krall

University of Nebraska-Lincoln Extension: Historical Materials

This circular is a progress report of corn hybrid performance tests conducted by the Agronomy Department and the Northeast, South Central, West Central and Panhandle Research Extension Centers of Nebraska and University of Wyoming at Torrington. Conduct of experiments and publication of results is a joint effort of the Agricultural Research Division and the Cooperative Extension Service. Tests were supported in part by fees paid by hybrid seed corn producers.

Ec01-105 Nebraska Corn Hybrid Tests 2001, Lenis Alton Nelson, Robert N. Klein, Roger Wesley Elmore, David D. Baltensperger, Charles A. Shapiro, Stevan Z. Knezevic, James Krall

University of Nebraska-Lincoln Extension: Historical Materials

This circular is a progress report of corn hybrid performance tests conducted by the Agronomy Department and the Northeast, South Central, West Central and Panhandle Research and Extension Centers of Nebraska and University of Wyoming at Torrington. Conduct of experiments and publication of results is a joint effort of the Agricultural Research Division and the Cooperative Extension Service.

Ec00-279 Synchronizing Esetrus In Beef Cattle, Richard J. Rasby, Gene H. Deutscher

University of Nebraska-Lincoln Extension: Historical Materials

Synchronization of estrus (heat) involves manipulating the estrous cycle of beef females in a herd so they can be bred at approximately the same time. There are several traditional protocols available for synchronizing estrus among beef females.

This extension circular discusses the programs and protocols used in synchronizing estrus in the beef cow.

Ec00-105 Nebraska Corn Hybrid Tests 2000, Lenis Alton Nelson, Robert N. Klein, Roger Wesley Elmore, David D. Baltensperger, Charles A. Shapiro, Stevan Z. Knezevic, James Krall

University of Nebraska-Lincoln Extension: Historical Materials

This circular is a progress report of corn hybrid performance tests conducted by the Agronomy Department and the Northeast, South Central, West Central and Panhandle Research and Extension Centers of Nebraska and University of Wyoming at Torrington. Conduct of experiments and publication of results is a joint effort of the Agricultural Research Division and the Cooperative Extension Service.

G89-952 Estrus (Heat) Detection Guidelines, Jeffrey F. Keown, Duane N. Rice

University of Nebraska-Lincoln Extension: Historical Materials

Ways to spot cows in heat are covered in this NebGuide.

Several factors are essential in maintaining a herd's reproductive health. Among the most important are: (1) maintaining accurate records, (2) knowing the visual signs of estrus (heat), (3) using proper heat detection aids, and (4) maintaining a herd health program.

By taking the four basic steps listed above, the expected calving interval for dairy animals will be close to the recommended 12 to 13 months. Beef producers need to strive for a 12-month calving interval to maintain a profitable enterprise.

This 12- to 13-month calving interval returns the most …

G85-760 Natural Air Corn Drying, Richard O. Pierce, Thomas L. Thompson

University of Nebraska-Lincoln Extension: Historical Materials

This NebGuide discusses factors affecting natural air corn drying system performance, and gives recommendations for bins filled over a one- to two-day period.

Natural air drying is an energy efficient drying method that is particularly well suited to Nebraska weather conditions. A high quality dried product, with little of the stress cracking or heat damage associated with high temperature drying, is an added attraction. However, good management practices must be followed to achieve satisfactory drying results.

A major concern with this method is overloading the bin with corn too wet to be dried without spoilage or deterioration, especially when the …

G85-741 Estrous Synchronization For Beef Cattle, Gene H. Deutscher

University of Nebraska-Lincoln Extension: Historical Materials

This NebGuide discusses the potential benefits of estrous synchronization, how the products and programs work, and the results and costs involved. Estrous (heat) synchronization can help beef producers improve production efficiency and economic returns. Controlling estrus and ovulation in cycling females means breeding is completed in a short period of time. Instead of females being bred over a 21-day period, synchronization can shorten the breeding period to less than 5 days, depending on the program selected. The use of synchronization has great potential for improving beef production, but it requires good management for success. Producers should understand the advantages, as …

G81-574 Reproductive Diseases In Cattle, Duane Rice

University of Nebraska-Lincoln Extension: Historical Materials

The reproductive diseases mentioned in this NebGuide comprise some of the more common problems confronting the cattle industry today.

Although many advances have been made in controlling reproductive diseases in cattle, serious losses are still common. These losses can be reduced by recognizing the diseases and following the proper management recommendations that are available today. Nearly 50 percent of reproductive failure in cattle is due to infectious diseases, and there are vaccines available that can prevent some of these. Management recommendations may include: 1) vaccines, 2) general sanitation, 3) artificial insemination (AI) or, if a problem is already present, 4) …

G80-530 Brooder House And Equipment For The Home Flock, Earl W. Gleaves

University of Nebraska-Lincoln Extension: Historical Materials

This NebGuide discusses housing and equipment needs for raising home poultry flocks.

This NebGuide lists and describes some of the types of houses and equipment that can be used to raise a home poultry flock. Other management suggestions are included in a series of NebGuides that are available from your county Extension office.

G80-537 Reproductive Trace Anatomy And Physiology Of The Cow, Gene H. Deutscher

University of Nebraska-Lincoln Extension: Historical Materials

Knowledge of basic reproduction will help a producer to obtain higher conception rates when using estrous synchronization and/or artificial insemination. The reproductive performance of a cow herd has a great influence on the income and profit realized. A good understanding of the anatomy and physiology of the cow's reproductive system is, therefore, beneficial for successful management. Knowledge of basic reproduction will help a producer to obtain higher conception rates when using estrous synchronization and/or artificial insemination. It will also allow for a better understanding of pregnancy examinations, reproductive diseases and calving difficulty problems.

Rb32-266 Cooling Milk On Nebraska Farms, P.A. Downs, E.B. Lewis

University of Nebraska-Lincoln Extension: Historical Materials

The desire of Nebraska people to continue the improvement of living conditions and to secure more healthful foods has been responsible for many changes in methods of caring for milk. One of the important factors in keeping milk sweet and of good quality is the process of cooling and keeping it cool until used. Three of these processes are as follows: placing containers of warm milk in any quantity of still water or still air at temperatures ranging from freezing to within a few degrees of the temperature of the milk, placing the containers in such positions that air or …