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Full-Text Articles in Education
Cardiac, Skeletal, And Smooth Muscle Mitochondrial Respiration: Are All Mitochondria Created Equal?, Song-Young Park, J. R. Gifford, R. H. I. Andtbacka, Joel D. Trinity, John R. Hyngstrom, Ryan S. Garten, Nikolaos A. Diakos, S. J. Ives, Flemming Dela, Steen Larsen, Stavros Drakos, Russell S. Richardson
Cardiac, Skeletal, And Smooth Muscle Mitochondrial Respiration: Are All Mitochondria Created Equal?, Song-Young Park, J. R. Gifford, R. H. I. Andtbacka, Joel D. Trinity, John R. Hyngstrom, Ryan S. Garten, Nikolaos A. Diakos, S. J. Ives, Flemming Dela, Steen Larsen, Stavros Drakos, Russell S. Richardson
Health and Kinesiology Faculty Publications
Unlike cardiac and skeletal muscle, little is known about vascular smooth muscle mitochondrial respiration. Therefore, the present study examined mitochondrial respiratory rates in smooth muscle of healthy human feed arteries and compared with that of healthy cardiac and skeletal muscles. Cardiac, skeletal, and smooth muscles were harvested from a total of 22 subjects (53 ± 6 yr), and mitochondrial respiration was assessed in permeabilized fibers. Complex I + II, state 3 respiration, an index of oxidative phosphorylation capacity, fell progressively from cardiac to skeletal to smooth muscles (54 ± 1, 39 ± 4, and 15 ± 1 pmol·s−1·mg−1, P < 0.05, respectively). Citrate synthase (CS) activity, an index of mitochondrial density, also fell progressively from cardiac to skeletal to smooth muscles (222 ± 13, 115 ± 2, and 48 ± 2 μmol·g−1·min−1, P …