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1: "To Know Ourselves", The U.S. Department Of Energy, The Human Genome Project
1: "To Know Ourselves", The U.S. Department Of Energy, The Human Genome Project
Genomics: Past & Future
AT THE END OF THE ROAD in Little Cottonwood Canyon, near Salt Lake City, Alta is a place of near-mythic renown among skiers. In time it may well assume similar status among molecular geneticists. In December 1984, a conference there, co-sponsored by the U.S. Department of Energy, pondered a single question: Does modern DNA research offer a way of detecting tiny genetic mutations—and, in particular, of observing any increase in the mutation rate among the survivors of the Hiroshima and Nagasaki bombings and their descendants? In short the answer was, Not yet. But in an atmosphere of rare intellectual fertility, …
2: "The Mapping Of Chromosome 16", Norman A. Doggett, Raymond L. Stallings, Carl E. Hildebrand, Robert K. Moyzis
2: "The Mapping Of Chromosome 16", Norman A. Doggett, Raymond L. Stallings, Carl E. Hildebrand, Robert K. Moyzis
Genomics: Past & Future
Human chromosome 16 is the main focus of the mapping efforts at Los Alamos. The large photomicrograph on these opening pages illustrates the starting point for those mapping efforts, the evaluation of our chromosome-16-specific library of cloned fragments. Among the 23 pairs of human chromosomes, one pair, chromosome 16, is identified by fluorescence in-situ hybridization. Thousands of yellow fluorescent probes derived from the clone library have hybridized to both copies of chromosome 16. The high density and uniform coverage of the fluorescent signals were a strong indication that we could use the library to construct a map of overlapping cloned …