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Sympathoinhibition And Vasodilation Contribute To The Acute Hypotensive Response Of The Superoxide Dismutase Mimic, Mntnbuoe-2-Pyp5+, In Hypertensive Animals, Sarah L. Schlichte, Elizabeth J. Pekas, Taylor J. Bruett, Elizabeth A. Kosmacek, Bryan T. Hackfort, Jordan M. Rasmussen, Kaushik P. Patel, Song-Young Park, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman

Health and Kinesiology Faculty Publications

The pathogenesis of hypertension has been linked to excessive levels of reactive oxygen species (ROS), particularly superoxide (O2•−), in multiple tissues and organ systems. Overexpression of superoxide dismutase (SOD) to scavenge O2•− has been shown to decrease blood pressure in hypertensive animals. We have previously shown that MnTnBuOE-2-PyP5+ (BuOE), a manganese porphyrin SOD mimic currently in clinical trials as a normal tissue protector for cancer patients undergoing radiation therapy, can scavenge O2•− and acutely decrease normotensive blood pressures. Herein, we hypothesized that BuOE decreases hypertensive blood pressures. Using angiotensin II (AngII)-hypertensive mice, we demonstrate that BuOE administered both intraperitoneally and …