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Age-Related Endothelial Dysfunction In Human Skeletal Muscle Feed Arteries: The Role Of Free Radicals Derived From Mitochondria In The Vasculature, Song-Young Park, Robert H. I. Andtbacka, John R. Hyngstrom, Van Reese, M. P. Murphy, Russell S. Richardson
Age-Related Endothelial Dysfunction In Human Skeletal Muscle Feed Arteries: The Role Of Free Radicals Derived From Mitochondria In The Vasculature, Song-Young Park, Robert H. I. Andtbacka, John R. Hyngstrom, Van Reese, M. P. Murphy, Russell S. Richardson
Health and Kinesiology Faculty Publications
Aim
This study sought to determine the role of free radicals derived from mitochondria in the vasculature in the recognized age-related endothelial dysfunction of human skeletal muscle feed arteries (SMFAs).
Methods
A total of 44 SMFAs were studied with and without acute exposure to the mitochondria-targeted antioxidant MitoQ and nitric oxide synthase (NOS) blockade. The relative abundance of proteins from the electron transport chain, phosphorylated (p-) to endothelial (e) NOS ratio, manganese superoxide dismutase (MnSOD) and the mitochondria-derived superoxide () levels were assessed in SMFA. Endothelium-dependent and endothelium-independent SMFA vasodilation was assessed in response to flow-induced shear stress, acetylcholine (ACh) …