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The Effect Of Acute Aerobic Exercise And Rapamycin Treatment On Autophagy And The Heat Shock Response In Peripheral Blood Mononuclear Cells Of Prediabetics, James Jermey Mccormick
The Effect Of Acute Aerobic Exercise And Rapamycin Treatment On Autophagy And The Heat Shock Response In Peripheral Blood Mononuclear Cells Of Prediabetics, James Jermey Mccormick
Health, Exercise, and Sports Sciences ETDs
Objectives: Recently, a malfunction of the autophagic pathway has been implicated with impaired glucose metabolism and progression from prediabetes to type 2 diabetes. Further, an interconnection has been suggested between the autophagy and heat shock protein (HSP) systems. The aims of the present study were to investigate the effects of exercise and rapamycin treatment (RAPA) on the autophagic process and HSP in peripheral blood mononuclear cells (PBMCs) from prediabetics compared to controls. Methods: Two groups matched for age and sex served as subjects and consisted of six prediabetic (42.4±11.7) and six controls (44.4±11.9). Subjects exercised at 50% of VO2max for …
Effect Of Branched-Chain Amino Acid Supplementation On Recovery Of Performance And Muscle Damage, & Autophagy And Heat Shock Protein Response, Trisha Vandusseldorp
Effect Of Branched-Chain Amino Acid Supplementation On Recovery Of Performance And Muscle Damage, & Autophagy And Heat Shock Protein Response, Trisha Vandusseldorp
Health, Exercise, and Sports Sciences ETDs
Purpose: To investigate: 1) if branched-chain amino acid supplementation (BCAA) enhances recovery from acute, eccentric resistance exercise as measured by indirect markers of muscle damage, and 2) the impact of acute, eccentric resistance exercise on markers of autophagy and heat shock protein during recovery. Methods: Twenty resistance-trained males were randomly assigned to eight days of BCAA or PLCB and adhered to a diet consisting of 1.2 g/kg/d protein. On day five, all subjects completed 10x8 eccentric squats at 70% one repetition maximum (1RM), followed by 5x20 split jumps. Plasma creatine kinase (CK), erythrocyte glutathione, vertical jump (VJ), maximal voluntary isometric …
Coordination Between Autophagy And The Heat Shock Response: Evidence From Exercise In Animals And Humans, Nathan H. Cole
Coordination Between Autophagy And The Heat Shock Response: Evidence From Exercise In Animals And Humans, Nathan H. Cole
Health, Exercise, and Sports Sciences ETDs
Proteins play a critical role in nearly every biological activity. In consequence, organismal health and homeostasis often hinges on the ability of intracellular regulatory systems to sustain the quality and function of these diverse, structurally complex macromolecules. Correct protein function depends on correct form, and during periods of destabilizing cellular stress, protein quality is managed in part by the heat shock response, which acts to support, isolate, and reform new or damaged proteins, and in part by the autophagic recycling of abnormal proteins, cytotoxic protein aggregates, and terminally damaged organelles. We conducted a pooled analysis of available research in humans …