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Altered Skeletal Muscle Mitochondrial Phenotype In Copd: Disease Vs. Disuse, Jayson R. Gifford, Joel D. Trinity, Oh-Sung Kwon, Gwenael Layec, Ryan S. Garten, Song-Young Park, Ashley D. Nelson, Russell S. Richardson

Health and Kinesiology Faculty Publications

Patients with chronic obstructive pulmonary disease (COPD) exhibit an altered skeletal muscle mitochondrial phenotype, which often includes reduced mitochondrial density, altered respiratory function, and elevated oxidative stress. As this phenotype may be explained by the sedentary lifestyle that commonly accompanies this disease, the aim of this study was to determine whether such alterations are still evident when patients with COPD are compared to control subjects matched for objectively measured physical activity (PA; accelerometry). Indexes of mitochondrial density [citrate synthase (CS) activity], respiratory function (respirometry in permeabilized fibers), and muscle oxidative stress [4-hydroxynonenal (4-HNE) content] were assessed in muscle fibers biopsied …