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Flavonol Specific 3-O Glucosyltransferase (Cp3gt) Mutant S20g+T21s: Enzyme Structure And Function, Hayden Fobare
Flavonol Specific 3-O Glucosyltransferase (Cp3gt) Mutant S20g+T21s: Enzyme Structure And Function, Hayden Fobare
Undergraduate Honors Theses
Flavonols are a major subclass of flavonoids and are considered the most abundant subclass of flavonoids. Flavonols are classified as having a hydroxyl group on the 3rd carbon of the C ring. The most prevalent modification to flavonols is glucosylation. The flavonol specific 3-O glucosyltransferase (Cp3GT) enzyme from grapefruit (Citrus paradisi) is the topic of this research and specifically adds glucose to flavonols at the 3-OH position. The level of activity varies depending on the flavonol structure. This makes Cp3GT an ideal model system for studying the structure/function relationship of Cp3GT using site-directed mutants. S20G+T21S is a …