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Determination Of Isotherms Of Enantiomers On A Chiral Stationary Phase Using Supercritical Fluid Chromatography, Wade Newlin Mack Ii
Determination Of Isotherms Of Enantiomers On A Chiral Stationary Phase Using Supercritical Fluid Chromatography, Wade Newlin Mack Ii
USF Tampa Graduate Theses and Dissertations
Supercritical fluids provide a robust, tunable environment with favorable transport properties and enhanced solubility. Supercritical carbon dioxide is an environmentally friendly substance that has distinct advantages to traditional solvents used in large scale chemical processing. Ibuprofen is an enantiomeric drug that has been shown to fight prostate cancer and has been used as a mild Alzheimer's disease treatment in the S conformation. Purification of high value products with decreased hazardous material consumption is accomplished by employing supercritical fluid chromatography (SFC). Large scale, single enantiomer purification of pharmaceuticals is dependent on scale-up information. Equilibrium isotherms provide the necessary information to scale-up …
Determination Of Ibuprofen Isotherm Using Supercritical Fluid Chromatography, Loi Ho
Determination Of Ibuprofen Isotherm Using Supercritical Fluid Chromatography, Loi Ho
USF Tampa Graduate Theses and Dissertations
Chromatography is widely used to determine physiochemical properties data including adsorption isotherm. In the separation of enantiomers through sorptive processes, supercritical fluids allow efficient and green alternatives to liquid solvent based systems. The isotherm information is vital in the development of operating policies and design of preparative chromatographic or moving bed separation schemes. Determination of sorption isotherms from experimental chromatographic elution data is automated and compared with different chromatogram model. Procedures were developed and validated for separation of R- and S- ibuprofen with supercritical 〖CO〗_2 and ethanol mixture as the mobile phase over a chiral stationary phase. The isotherms for …