Arts and Humanities Commons^™

Preventing And Treating Narcotic Addiction — A Century Of Federal Drug Control, David Courtwright

David T. Courtwright

Infertility And Moral Luck: The Politics Of Women Blaming Themselves For Infertility, Carolyn Mcleod, Julie Ponesse

Julie E Ponesse

Infertility can be an agonizing experience, especially for women. And, much of the agony has to do with luck: with how unlucky one is in being infertile, and in how much luck is involved in determining whether one can weather the storm of infertility and perhaps have a child in the end. We argue that bad luck associated with being infertile is often bad moral luck for women. The infertile woman often blames herself or is blamed by others for what is happening to her, even when she cannot control or prevent what is happening to her. She has simply …

The Saint Of Worcester: Why Pilgrims Visit Audrey Santo, Mathew Schmalz

Mathew Schmalz

No abstract provided.

Intersectoral And Interagency Partnerships To Investigate Youth Help-Seeking And The Reponses Of At-Risk Young Men To Intervention Services, Coralie Wilson, Frank Deane, Joseph Ciarrochi

joseph Ciarrochi

No abstract provided.

Suicidal Ideation And Help-Negation: Not Just Hopelessness Or Prior Help, Frank Deane, Coralie Wilson, Joseph Ciarrochi

joseph Ciarrochi

This article reports the first study of its kind to specifically examine help-negation for suicidal thoughts (i.e., the inverse relationship between help-seeking intentions for suicidal thinking and levels of suicidal ideation) in a non-clinical university sample. The study establishes the existence of the phenomenon in individuals before levels of suicidal ideation become acute and raises numerous implications for national and international mental health policy development, clinical practice, and directions for prevention and early intervention.

The Increasing Incidence Of Suicide: Economic Development, Individualism, And Social Integration, Gregory Scott, Joseph Ciarrochi, Frank Deane

joseph Ciarrochi

Despite significant improvement in physical health, suicide continues to represent a significant burden in the economically advanced countries. Given that the causes of suicide are not fully known, and that suicide cannot be predicted nor prevented at the individual level, national suicide rates might best be reduced by reducing the overall number of people exposed to suicide risk factors. However, economic development promotes individualism and low social integration, both of which increase suicide risk. For example, high female labor force participation and divorce, indicative of low social integration, are associated with higher suicide rates. Similarly, there appear to be social …

Can Hopelessness And Adolescents' Beliefs And Attitudes About Seeking Help Account For Help Negation?, Coralie Wilson, Joseph Ciarrochi, Frank Deane

joseph Ciarrochi

This article reports the first time the help-negation relationship for suicidal thoughts (i.e., the inverse relationship between help-seeking intentions for suicidal thinking and levels of suicidal ideation) has been specifically examined, and established, in a non-clinical adolescent sample. The study raises major implications for national and international suicide prevention policy development, clinical practice and strategies for ongoing prevention and early intervention

Development Of The Levels Of Emotional Awareness Scale For Children (Leas-C), Joseph Ciarrochi, Frank Deane, Jane Bajgar, Richard Lane

joseph Ciarrochi

A performance-based assessment of the structure and complexity of emotional awareness was developed, the Levels of Emotional Awareness Scale for Children (LEAS-C). A pilot study (N=6, ages 9-12, M(age) =10.2 years) was conducted to construct, trial, and select scenarios suitable for the scale. A larger validity study (N=51, ages 10-11, M(age) =10.3 years) examined the relationship between the LEAS-C and two emotion knowledge tasks: emotion expressions and emotion comprehension; two verbal tasks: vocabulary and verbal productivity; and a cognitive developmental measure: the Parental Descriptions Scale (PDS). Gender differences in LEAS-C performance were also examined. The LEAS-C was significantly related to …

The Phenomenology Of Intersubjectivity In Jaspers And Husserl: On The Capacities And Limits Of Empathy And Communication In Psychiatric Praxis, Sebastian Luft, J. Schlimme

Sebastian Luft

In this article, we present two accounts of intersubjectivity in Jaspers and Husserl, respectively. We argue that both can be brought together for a more satisfying account of empathy and communication in the context of psychiatric praxis. But while we restrict ourselves for the most part to this praxis, we also indicate the larger agenda that drives Jaspers and Husserl, despite all disagreement. Here we spell out, in particular, how a phenomenologically inspired account of empathy and intersubjectivity can have larger ramifications for a theory of social life and interaction. Finally, we argue for a ‘relaxed' view concerning the relation …

Deaf Individuals’ Bilingual Abilities: American Sign Language Proficiency, Reading Skills, And Family Characteristics, Brittany Freel, M. Clark, Melissa Anderson, Gizelle Gilbert, Millicent Musyoka, Peter Hauser

Melissa L. Anderson

The current study investigated the bilingual abilities of 55 Deaf individuals, examining both American Sign Language (ASL) competency and English reading skills. Results revealed a positive relationship between ASL competency and English skills, with highly competent signers scoring higher on a measure of reading comprehension. Additionally, family characteristics (e.g., parental education level, family hearing status) were entered into the analysis to ascertain their effect on Deaf individuals’ bilingual abilities. The findings support the theory that competency in ASL may serve as a bridge to the acquisition of English print. Moreover, the findings provide support for the critical period hypothesis for …

Choreographing Lived Experience: Dance, Feelings And The Storytelling Body, Karin Eli, Rosie Kay

Karin Eli

Although narrative-based research has been central to studies of illness experience, the inarticulate, sensory experiences of illness often remain obscured by exclusively verbal or textual inquiry. To foreground the body in our investigation of subjective and intersubjective aspects of eating disorders, we—a medical anthropologist and a contemporary dance choreographer—designed a collaborative project, in which we studied the experiences of women who had eating disorders, through eight weeks of integrating dance practice-based, discussion-based and interview-based research. Grounded in the participants’ own reflections on choreographing, dancing and watching others perform solos about their eating disordered experiences, our analysis examines the types of …

Brief Motivational Interviewing Training For Allied Health Professionals: Targeting Eating Behaviour Change, Elizabeth Edwards, Peta Stapleton

Dr Elizabeth Edwards

No abstract provided.

Barriers And Facilitators For Colorectal Cancer Screening Practices In The Latino Community: Perspectives From Community Leaders, Ana Natale-Pereira, Jonnie Marks, Marielos Vega, Dawne Mouzon, Shawna Hudson, Debbie Salas-Lopez

Debbie Salas-Lopez MD, MPH

BACKGROUND: Colorectal cancer (CRC) is the second-leading cause of cancer-related death in the United States and the third most commonly diagnosed cancer among Latinos. While Latinos represent one of the fastest-growing ethnic groups in the United States, their participation in cancer prevention and treatment trials is low. METHODS: Thirty-six Latino community leaders participated in five focus groups that examined factors affecting CRC screening practices among Latinos. RESULTS: The top four barriers identified were low knowledge and awareness of CRC, language barriers, lack of insurance, and undocumented legal status. Additional barriers included seeking health care only when sick, fatalism, fear, denial …

Perspectives On Cancer Screening Among Latino Community Members And Internal Medicine Residents, Debbie Salas-Lopez, Dawne Mouzon, Jonnie Marks, Neil Kothari, Ana Natale-Pereira

Debbie Salas-Lopez MD, MPH

BACKGROUND: Latinos have lower rates of cancer screening, partially because of cultural beliefs that conflict with those of health care professionals. Moreover, established programs for training physicians in cultural competency often fail to incorporate input from the community.

METHODS: To explore beliefs about cancer and cancer screening among Latino community members and internal medicine residents. Three focus groups of Latino community members (n = 31) and one focus group of internal medicine residents (n = 9) were conducted to compare ideas regarding cancer and cancer screening.

RESULTS: We identified clear disconnects between residents and Latino community members regarding their understandings …

Development Of Antigen-Specific Memory Cd8+ T Cells Following Live-Attenuated Chimeric West Nile Virus Vaccination, Heidi Smith, Thomas Monath, Pamela Pazoles, Alan Rothman, Diane Casey, Masanori Terajima, Francis Ennis, Farshad Guirakhoo, Sharone Green

Alan Rothman

ChimeriVax-WN02 is a novel live-attenuated West Nile virus (WNV) vaccine containing modified WNV premembrane (prM) and envelope (E) sequences inserted into the yellow fever 17D vaccine genome. We investigated the induction and evolution of CD8(+) T cell responses to a WNV envelope epitope, which is a dominant target in naturally infected HLA-A*02-positive individuals. WNV epitope-specific CD8(+) T cells were detected by HLA tetramer staining in 22 of 23 donors tested, with peak frequencies occurring between days 14 and 28. WNV epitope-specific T cells evolved from an effector phenotype to a long-lived memory phenotype. In the majority of donors, CD8(+) T …

Intracellular Cytokine Production By Dengue Virus-Specific T Cells Correlates With Subclinical Secondary Infection, Steven Hatch, Timothy Endy, Stephen Thomas, Anuja Mathew, James Potts, Pamela Pazoles, Daniel Libraty, Robert Gibbons, Alan Rothman

Alan Rothman

The pathophysiology of dengue virus infection remains poorly understood, although secondary infection is strongly associated with more severe disease. In the present study, we performed a nested, case-control study comparing the responses of pre-illness peripheral blood mononuclear cells between children who would subsequently develop either subclinical or symptomatic secondary infection 6-11 months after the baseline blood samples were obtained and frozen. We analyzed intracellular cytokine production by CD4(+) and CD8(+) cells in response to stimulation with dengue antigen. We found higher frequencies of dengue virus-specific TNFalpha, IFNgamma-, and IL-2-producing T cells among schoolchildren who subsequently developed subclinical infection, compared with …

Determinants Of Inapparent And Symptomatic Dengue Infection In A Prospective Study Of Primary School Children In Kamphaeng Phet, Thailand, Timothy Endy, Kathryn Anderson, Ananda Nisalak, In-Kyu Yoon, Sharone Green, Alan Rothman, Stephen Thomas, Richard Jarman, Daniel Libraty, Robert Gibbons

Alan Rothman

BACKGROUND: Dengue viruses are a major cause of morbidity in tropical and subtropical regions of the world. Inapparent dengue is an important component of the overall burden of dengue infection. It provides a source of infection for mosquito transmission during the course of an epidemic, yet by definition is undetected by health care providers. Previous studies of inapparent or subclinical infection have reported varying ratios of symptomatic to inapparent dengue infection.

METHODOLOGY/PRINCIPAL FINDINGS: In a prospective study of school children in Northern Thailand, we describe the spatial and temporal variation of the symptomatic to inapparent (S:I) dengue illness ratio. Our …

T-Cell Responses To Dengue Virus In Humans, Ichiro Kurane, Takaji Matsutani, Ryuji Suzuki, Tomohiko Takasaki, Siripen Kalayanarooj, Sharone Green, Alan Rothman, Francis Ennis

Alan Rothman

Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8- and CD8+CD4- T cells in humans. In primary infection, T-cell responses to DENV are serotype cross-reactive, but the highest response is to the serotype that caused the infection. The epitopes recognized by DENV-specific T cells are located in most of the structural and non-structural proteins, but NS3 is the protein that is most dominantly recognized. In patients with dengue hemorrhagic fever (DHF) caused by secondary DENV infection, T cells are highly activated in vivo. …

B-Cell Responses During Primary And Secondary Dengue Virus Infections In Humans, Anuja Mathew, Kim West, Siripen Kalayanarooj, Robert Gibbons, Anon Srikiatkhachorn, Sharone Green, Daniel Libraty, Smita Jaiswal, Alan Rothman

Alan Rothman

Low-avidity serotype-cross-reactive antibodies are hypothesized to play a key role in triggering severe disease in patients with secondary dengue virus (DENV) infection. However, there is little systematic information about the frequency, avidity, and cross-reactivity of DENV-specific B cells in individuals experiencing primary instead of secondary infection. We compared DENV-specific B-cell responses in a cohort of Thai children with primary or secondary DENV infection. B cells specific for DENV precursor membrane protein, envelope (E) protein, and nonstructural protein 1 were detectable in immune peripheral blood mononuclear cells with the highest frequencies of DENV E-specific B cells detected in patients experiencing primary …

Health Behaviour Change Counselling For Healthy Eating And Physical Activity: An Examination Of Brief Motivational Interviewing Training, Elizabeth Edwards(Nee Scott), Peta Stapleton

Dr Elizabeth Edwards

No abstract provided.

Caritas In Communion: Theological Foundations Of Catholic Health Care, M. Lysaught

M. Therese Lysaught

No abstract provided.

Brief Motivational Interviewing For Healthy Eating And Physical Activity, Peta Stapleton, Elizabeth Edwards(Nee Scott)

Dr Elizabeth Edwards

No abstract provided.

Development Of Antigen-Specific Memory Cd8+ T Cells Following Live-Attenuated Chimeric West Nile Virus Vaccination, Heidi Smith, Thomas Monath, Pamela Pazoles, Alan Rothman, Diane Casey, Masanori Terajima, Francis Ennis, Farshad Guirakhoo, Sharone Green

Sharone Green

ChimeriVax-WN02 is a novel live-attenuated West Nile virus (WNV) vaccine containing modified WNV premembrane (prM) and envelope (E) sequences inserted into the yellow fever 17D vaccine genome. We investigated the induction and evolution of CD8(+) T cell responses to a WNV envelope epitope, which is a dominant target in naturally infected HLA-A*02-positive individuals. WNV epitope-specific CD8(+) T cells were detected by HLA tetramer staining in 22 of 23 donors tested, with peak frequencies occurring between days 14 and 28. WNV epitope-specific T cells evolved from an effector phenotype to a long-lived memory phenotype. In the majority of donors, CD8(+) T …

B-Cell Responses During Primary And Secondary Dengue Virus Infections In Humans, Anuja Mathew, Kim West, Siripen Kalayanarooj, Robert Gibbons, Anon Srikiatkhachorn, Sharone Green, Daniel Libraty, Smita Jaiswal, Alan Rothman

Sharone Green

Low-avidity serotype-cross-reactive antibodies are hypothesized to play a key role in triggering severe disease in patients with secondary dengue virus (DENV) infection. However, there is little systematic information about the frequency, avidity, and cross-reactivity of DENV-specific B cells in individuals experiencing primary instead of secondary infection. We compared DENV-specific B-cell responses in a cohort of Thai children with primary or secondary DENV infection. B cells specific for DENV precursor membrane protein, envelope (E) protein, and nonstructural protein 1 were detectable in immune peripheral blood mononuclear cells with the highest frequencies of DENV E-specific B cells detected in patients experiencing primary …

Long Term Recall Of Memory Cd8 T Cells In Mice To First And Third Generation Smallpox Vaccines, Sharone Green, Francis Ennis, Anuja Mathew

Sharone Green

Since long-term immunity is a critical component of any effective vaccine, we compared over a 15-month period, the strength, durability and specificity of immunity of an attenuated smallpox vaccine Modified Vaccinia Ankara (MVA) to the New York City Board of Health (NYCBH) vaccine. The frequencies of CD8(+) T cells to an immunodominant CD8 T cell epitope B8R(20-27) remained remarkably stable in mice given either MVA or NYCBH. Both groups were also protected from a lethal intranasal challenge with Western Reserve strain of vaccinia virus (VACV-WR). Cytokine responses to virus-specific peptides were detectable with significant boosting upon challenge. Expression of most …

Which Stressors Are Associated With Which Forms Of Depression In A Homogenous Sample? An Analysis Of The Effects Of Lifestyle Changes And Demands On Five Subtypes Of Depression, Vicki Bitsika, Christopher Sharpley

Vicki Bitsika

Background: Although depression is often considered as a single or unitary construct, evidence indicates the existence of several major subtypes of depression, some of which have distinct neurobiological bases and treatment options. Objective: To explore the incidence of five subtypes of depression, and to identify which lifestyle changes and stressor demands are associated with each of five established subtypes of depression, within a homogenous non-clinical sample. Method: 398 Australian university students completed the Effects of University Study on Lifestyle Questionnaire to identify their major stressors, plus the Zung Self-Rating Depression Scale to measure their symptomatology. Regression analysis was used to …

Fibre: Male Participants Not Getting Enough, Rebecca Thorne, Jane O'Shea, Qingsheng Zhang, Linda Tapsell, Marijka Batterham, Karen Charlton

Qingsheng Zhang

A regular intake of dietary fibre has been associated with a number of health benefits. Consuming a high fibre diet may significantly lower the risk of developing heart disease, stroke, hypertension, diabetes and obesity (Anderson et al, 2009). Foods high in fibre such as fruit, vegetables, legumes and wholegrains are regularly included in diets targeting weight loss as they are low in fat, sugar and salt and contain a number of vitamins and minerals. Participants in trials using healthy background diets may increase their fibre intake in addition to the study variables. The aim of this study was to report …

Start Date May Predict Attrition 6 Months Into A 12mth Dietary Intervention Weight Loss Trial, Jane O'Shea, Linda Tapsell, Marijka Batterham, Karen Charlton, Yasmine Probst, Rebecca Thorne, Qingsheng Zhang, Holley Jones

Qingsheng Zhang

Participant recruitment is a difficult and time consuming aspect of clinical trials, often resulting in delays and budget overruns. Having reached recruitment targets the next challenge is participant retention. Some weight-loss studies have attrition rates around 60% which may introduce bias in the results. It may be possible to reduce attrition rates if known predictors can be found but to date few studies produced consistent results. The aim of this exploratory study was to determine whether start date could be a predictor of attrition for participants involved in the SMART weight loss clinical trial (ACTRN12608000425392). Recruitment for the trial occurred …

Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Hormonal Markers Of Appetite, Karen Charlton, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Jane O'Shea, Qingsheng Zhang, Eleanor Beck

Qingsheng Zhang

The effects of three different meat-containing breakfast meals (pork, beef or chicken) on acute satiety and appetite regulatory hormones were compared using a within-subjects study design. Thirty fasting non-smoking pre-menopausal women attended a research centre on three test days to consume, a meat-containing meal matched in energy (kJ) and protein content, palatability, and appearance. No difference was found between meat groups for either energy intake or macronutrient profile of food consume data subsequent ad libitum buffet lunch, or over the rest of the day. Visual Analogue Scale(VAS) ratings for hunger and satiety over an 180min period did not differ between …

Cholesterol-Lowering Effects Of B-Glucan Containing Breakfast Cereals And Snack Bars, Karen Charlton, Linda Tapsell, Marijka Batterham, Jane O'Shea, Rebecca Thorne, Qingsheng Zhang, Eleanor Beck

Qingsheng Zhang

No abstract provided.