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Self-Assessment Tool For Evaluating Periodontal Conditions, Haslina Rani, Tuti Ningseh Mohd-Dom, Shahida Mohd-Said, Nur Azwani Johari

Makara Journal of Health Research

Background: The global prevalence of periodontal disease is steadily rising. Early detection through the active screening of potential patients is important because periodontal disease leads to high disease, clinical, and economic burdens. The aim of this study is to develop a simple periodontal assessment tool for the Malay-speaking population; this tool is referred to in this work as MyGusi.

Methods: Translation and back-translation of a self-assessment tool containing 10 items related to periodontal health conditions and risk behaviors were conducted by three bilingual translators. Nine periodontists were selected to determine the content validity of the tool. After pre-testing …

Oral Microbiome And Gingival Tissue Apoptosis And Autophagy Transcriptomics, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Elliot Neumann, Luis Orraca, Janis Gonzalez Martinez, Octavio A. Gonzalez

Dental Medicine Faculty Publications

Objective: This study focused on documenting characteristics of the gingival transcriptome during various stages of periodontitis targeting genes associated with apoptotic and autophagic pathways and changes that specifically associate with features of the oral microbiome. Methods: Macaca mulatta (n = 18; 12-23 years) were examined at baseline and 0.5, 1, and 3 months of disease progression, as well as 5 months with clinical disease resolution. 16S sequencing and microarray analyses examined changes in the microbiome and gingival transcriptome, respectively, at each time point from every animal. Results: Specific patterns of apoptotic and autophagic genes were identified related to the initiation …

Oral Microbiome And Gingival Tissue Apoptosis And Autophagy Transcriptomics, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Elliot Neumann, Luis Orraca, Janis Gonzalez Martinez, Octavio A. Gonzalez

Center for Oral Health Research Faculty Publications

Objective: This study focused on documenting characteristics of the gingival transcriptome during various stages of periodontitis targeting genes associated with apoptotic and autophagic pathways and changes that specifically associate with features of the oral microbiome.

Methods: Macaca mulatta (n = 18; 12–23 years) were examined at baseline and 0.5, 1, and 3 months of disease progression, as well as 5 months with clinical disease resolution. 16S sequencing and microarray analyses examined changes in the microbiome and gingival transcriptome, respectively, at each time point from every animal.

Results: Specific patterns of apoptotic and autophagic genes were identified related to the …

Maternal Chronic Oral Infection With Periodontitis And Pericoronitis As A Possible Risk Factor For Preeclampsia In Egyptian Pregnant Women (Microbiological And Serological Study)., Lobna Azziz, Hala El-Menoufy, Rehab Tarek Elsharkawy, Mona Z. Zaghloul, Dina Sabry

Future Dental Journal

Background: Several studies have hypothesized that oral infection may increase the risk of preeclampsia. We explore the relationship between chronic oral infection and the risk of preeclampsia in Egyptian pregnant women. Methodology: Forty preeclamptic women with periodontitis and/or pericoronitis (group I) and 40 control subjects having periodontitis and/or pericoronitis (group II) were subjected to microbiological assessment of subgingival plaque, pseudo-pocket and placental samples. TNF-a was determined in gingival crevicular fluid (GCF), saliva and serum by ELISA and real time PCR. Results: There was no statistically significant difference between the two groups as regards to subgingival plaque and pericoronal pseudo-pocket organisms …

The Effect Of Mechanical Vibration On Alveolar Bone Following Experimental Periodontitis: A Time Course Study, Joshua Murphy

Master's Theses (2009 -)

Introduction: High-frequency vibration with low magnitude acceleration has varying effects on alveolar bone. The objectives of this study were to establish a murine model for periodontitis and to explore the best time window of this model to investigate the effects of high frequency, low magnitude mechanical vibration on alveolar bone following ligature-induced experimental periodontitis. Materials and Methods: Ninety-five 11-week-old inbred strain C57BL/67 male mice were randomly assigned into four groups: 1) healthy control (n = 9); 2) healthy + mechanical vibration (n = 8); 3) experimental periodontitis + no treatment (n=7); and 4) experimental periodontitis + vibration (n = 9). …

Commentary: Phytocannabinoids As Therapeutic Agents To Combat Chronic Gingival Disease., Nick Narek Ohanian

Pacific Journal of Health

The therapeutic potential of cannabis has been harnessed for thousands of years yet the United States Food and Drug Administration (FDA) has still not approved cannabis as a safe or effective drug. The FDA has, however, approved the manufacturing of pharmaceutical drugs, which contain a “synthetic version of a substance that is present in the marijuana” and other compounds that mimic its action. A search of the US National Library of Medicine and National Institute of Health for keywords “CBD” and “Periodontitis” together yields only 2 publications. Although the current State and Federal regulations on the use of cannabis for …

The Emerging Oral Pathogen, Filifactor Alocis, Disrupts Neutrophil Functions To Enhance Survival And Dysregulate Inflammation., Irina Miralda Molina

Electronic Theses and Dissertations

Periodontitis is an irreversible, chronic inflammatory disease where pathogenic microbial communities accumulate in the gingival crevice. Advances in culture-independent techniques have facilitated the identification of new bacterial species in periodontal lesions, such as the Gram-positive anaerobe, Filifactor alocis. Neutrophils are a major component of the innate host response, and the outcome of their interaction with F. alocis may be a determinant of oral health status. While neutrophil functions typically protect the host against periodontal disease, oral pathogens have adapted to evade or disarm neutrophil microbicidal functions while promoting mechanisms that drive inflammation, which also provides a source of nutrients …

Tobacco Enhances Bacterial-Induced Periodontal Bone Loss In Mice., Mina Iskander

Electronic Theses and Dissertations

Background: Tobacco smoking is the leading environmental risk factor for periodontal diseases. Delineation of the mechanisms underlying tobacco-induced or exacerbated periodontitis is hampered by the lack of an appropriate and reliable animal model. Hypothesis: We hypothesized that Porphyromonas-gingivalis-infected, cigarette smoke-exposed mice would represent reproducible models of acute (ligature model) and chronic (oral gavage model) tobacco-enhanced periodontitis that reflect multiple aspects of the disease noted in human smokers. Methods: In a chronic oral gavage disease model, Balb/c mice (6-8 weeks, 4 groups of n = 6 per group) were exposed to smoke produced by a Teague-10 smoking machine from 1R6F research …

Oral Health And Quality Of Life: A Clinic-Based Sample, Kinan M. Al-Bitar

Master's Theses (2009 -)

Attachment loss due to periodontal diseases is associated with functional limitations as well as physical pain and psychological discomfort, which may lead to a reduced quality of life. This manuscript is intended to answer the question, if periodontal status has an effect on oral health related quality of life. Survey data were collected in an U.S. dental school clinical setting from n=97 adults (54% females, average age 51 years) in a cross- sectional study. Quality of life related to oral health was assessed with the Oral Health Impact Profile (OHIP-49). Additional measures using the DMFT index, periodontal status, dental anxiety, …

Peri-Implantitis Risk Prediction Using A Computer Based Periodontal Risk Calculator Tool: A Retrospective Study, Walaa Al Zaibak

Master's Theses (2009 -)

Introduction: Although literature is abundant on the diagnosis and management of peri-implantitis after it has occurred, to our current knowledge there are no studies that have specifically looked into the relationship between peri-implantitis and the periodontal risk assessment tool used for natural dentitions.Material and Methods: In this retrospective study, the patient population included patients (>20 years of age) who had implants placed and restored at Marquette University School of Dentistry (MUSOD) from 2008 to 2016. Further, the restored implants in these patients must have been in function for at least one year and followed up in the school …

Probiotic Biotherapy: Discussing Its Influential Role In Oral Health, Karla Florez, Claudette Sullano

Dental Hygiene Student Scholarship

Introduction: Probiotics are widely known for their health promoting benefits, especially with its association to gastrointestinal health. For many years, most research has been focused on the prevention or treatment of gastrointestinal infections or diseases. However, recently probiotics has been a subject of investigation with its association to oral health. This review of literature is designed to analyze the effectiveness of using probiotics as a preventative and therapeutic method for oral infections/diseases such as periodontitis, dental caries, and the like.

Methods: Databases such as the PubMed, and Google Scholar were utilized to find current and relevant findings for this …

The Potential Effects Of Hormonal Therapy And Stress On The Oral Health Of The Transitioning Population, Elena G. Cantwell, Devon Mcclure

Dental Hygiene Student Scholarship

Problem: In terms of healthcare, the transgender population is underserved. Unfortunately, these individuals often experience stress related to seeking preventative care and fear discrimination. These factors preventing them from seeking care, in addition to hormone therapy taken during the transition process, could have severe impacts on their dental health. The purpose of this study is to establish a link between the hormone therapy used during gender transitioning and the effect on oral health. While there is a correlation between hormone replacement therapy and clinical evidence that sex hormones can impact on periodontal tissues, few studies have linked this knowledge to …

Selenomonas Sputigena: Growth Conditions And Projected Virulence Factors Of An Emerging Oral Pathogen, Kayla A. Keller

Theses and Dissertations

Periodontal diseases are ubiquitous diseases. They can affect people through a chronic infection that happens over a lifetime, but also as an aggressive infection that afflicts the younger population. It not only results in tooth loss and a lower quality of life, but it can also lead to fatal secondary infections like cervical cancer, heart disease, and Alzheimer’s disease. This study looks at Selenomonas sputigena, an emerging oral pathogen, that has been hypothesized to contribute to periodontal disease. It has been linked to fatal septicemia and has been found in increased abundance within the oral biofilm during peak infection. …

Amixicile As A Novel Antimicrobial Treatment For Periodontitis: A Pilot Study In The Non-Human Primate, Macaca Mulatta, Denver J. Lyons

Theses and Dissertations

Periodontitis is an inflammatory disease with a bacterial etiology in a susceptible host. Given the bacterial etiology, a selective antimicrobial agent with minimal side effects could be a useful adjunct to traditional therapy. Amixicile is a novel antimicrobial that targets the pyruvate: ferredoxin oxidoreductase (PFOR) which is an enzyme that is critical for anaerobic bacterial metabolism. It has been found to have no effect on commensal, aerobic microbes and has little to no side-effects thus far in animal models. In this study, two nonhuman primates of the Macaca mulatta species with naturally occurring mild chronic periodontitis were studied before and …