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Periodontal Regeneration Related To Periodontitis Treated By Garden Cress And Ozone Therapy. (Randomized Clinical &Experimental Study), Zienab S. Farid, Doaa Adel Habba, Gihan Adel Balbola, Noura Mohammed Bakr

Journal of Medicine in Scientific Research

Objective: In this article, garden cress and ozone were evaluated for their potential therapeutic properties of PDL and resorption of alveolar bone in the periodontal tissues based on rats' experimental periodontitis and to assess the clinical effectiveness of local application of garden cress and ozone for treatment and management of periodontitis patients using scaling and root planing. Methodology: Thirty mature Wistar male albino rats. Three groups of rats were formed; periodontitis without treatment, periodontitis with garden cress, and periodontitis plus ozone therapy. The present study also included thirty periodontitis Patients were randomly allocated to one of three groups of ten …

Oral And Dental Health In Systemic Sclerosis: Is It A Window To Other Systemic Affections?, Omnia A Abubakr, Taghreed F M M Mostafa, Mohamed A Hamdy

Journal of Medicine in Scientific Research

Background: Oral and periodontal manifestations are common in systemic sclerosis (SSc) which may result in poor nutritional status and significant morbidity. Better understanding of these manifestations is crucial for better patient outcomes. We aimed to evaluate dental and oral manifestations in patients with SSc in comparison to healthy control and to study the relationship between these findings and systemic sclerosis disease activity index, skin thickness, other systemic affection, as well as the oral health-related quality of life in these patients Patients and Methods: 50 patients with SSc were included in this case-control study (Group A) and 50 apparently healthy controls …

Adjunctive Use Of Laser Biostimulation With Nonsurgical Periodontal Therapy: A Split Mouth, Randomized, Case-Control Study In Diabetic And Nondiabetic Periodontitispatients, Funda Akansel, Umur Sakallioğlu, Müge Lütfi̇oğlu, Feyza Otan Özden, Adil Karadağ

Turkish Journal of Medical Sciences

Laser biostimulation therapy (LBT) is suggested to have positive effects on periodontal healing. This study evaluatedLBT with nonsurgical periodontal therapy (NSPT) in diabetes mellitus (DM) and systemic health (SH) conditions.Materials and methods: Thirty periodontitis patients (15 with DM and 15 with SH) were included in the study, which had a split-mouthdesign, by applying LBT in the mouth of the same systemic condition. Thus, 4 study groups were formed, as 1) NSPT – DM: NSPT alonein DM, 2) NSPT + LBT – DM: NSPT + LBT application in DM, 3) NSPT – SH: NSPT alone in SH, and 4) NSPT + …

The Role Of Probiotics For Preventing Dysbiosis In Periodontal Disease: A Randomized Controlled Trial, Tuğba Şahi̇n, Gülçin Akca, Nurdan Özmeri̇ç

Turkish Journal of Medical Sciences

Scaling and root planing remain inadequate in periodontitis treatment caused by dysbiotic microbial dental plaque. The aim of this clinical trial is to evaluate the effects of probiotics and kefir consumption in initial periodontal therapy (IPT) on oral microbiota composition and treatment outcomes in patients with periodontitis.Materials and methods: The study was carried out in the Gazi University Department of Periodontology, including a sample size of 36 individuals and utilizing a randomized controlled design. Thirty-six patients with periodontitis were randomly allocated to three groups: one receiving probiotic treatment, another receiving kefir, and a third serving as the control group. Obtaining …

E-Cigarettes: What Is The Relationship Between E-Cigarette Usage And Periodontal Disease?, Deborah Rose

Electronic Theses and Dissertations

The dental community has a broad understanding of how traditional combustible cigarettes affect the oral cavity of the dental patient but there is little research available on the effects that e-cigarettes have on the patient’s dental health. Vaping products have been marketed as a healthier option over traditional combustible cigarettes. Since they were first introduced in 2003, very little research has been performed to understand their dental implications. This project was executed to investigate the chemicals associated with these vaping products and how they possibly contribute to the progression of periodontal disease. This research project was conducted with the contribution …

Pelvic Infection Caused By Periodontitis: A Case Report, Cuihong Tian, Hongle Yan, Ping Tang, Jinqiu Shi, Maolian Liang, Yanyan Wan, Weiping Li, Xizhuo Sun, Chenglu Qin

Research outputs 2022 to 2026

Oral bacteria in patients with periodontitis can disseminate into the bloodstream via broken oral epithelial cells, causing odontogenic maxillofacial infections, brain abscesses and endocarditis. However, pelvic infection caused by periodontitis is rare. The case of a 48-year-old woman with a long history of recurrent periodontal infections, who complained of abdominal distention and pain for 14 days after dental implantation, is reported here. Pelvic ultrasound and magnetic resonance imaging signaled multiple inflammatory encapsulated effusions in the posterior uterus, which were removed by laparoscopic surgery and tested with metagenomic next-generation sequencing (mNGS). Through mNGS, numerous oral pathogens, including Filifactor alocis, were identified …

Cannabinoids In Periodontology: Where Are We Now?, Yésica Carmona Rendón, Hernán Santiago Garzón, Bruno Bueno-Silva, Roger M Arce, Lina Janeth Suárez

Journal Articles

INTRODUCTION: Cannabinoids are a well-documented treatment modality for various immune and inflammatory diseases, including asthma, chronic obstructive pulmonary disease, Crohn's disease, arthritis, multiple sclerosis, and a range of neurodegenerative conditions. However, limited information is available regarding the therapeutic potential of cannabinoids in treating periodontal disease.

OBJECTIVE: The objective of this study is to analyze the current evidence on the antibacterial and immunomodulatory effects of cannabis and its role in the healing and regeneration processes within periodontal tissues.

RESULTS: This review discusses the potential role of cannabinoids in restoring periodontal tissue homeostasis.

CONCLUSIONS: The examination of the endocannabinoid system and the …

Occlusive Membranes For Guided Regeneration Of Inflamed Tissue Defects., Woojin Choi, Utkarsh Mangal, Jin-Young Park, Ji-Yeong Kim, Taesuk Jun, Ju Won Jung, Moonhyun Choi, Sungwon Jung, Milae Lee, Ji-Yeong Na, Du Yeol Ryu, Jin Man Kim, Jae-Sung Kwon, Won-Gun Koh, Sangmin Lee, Patrick T J Hwang, Kee-Joon Lee, Ui-Won Jung, Jae-Kook Cha, Sung-Hwan Choi, Jinkee Hong

Henry M. Rowan College of Engineering Faculty Scholarship

Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration …

Periodontal Status And Inflammatory Markers In Gingival Crevicular Fluid Of Patients With Periodontitis And Colorectal Cancer, Sandu Râmboiu, Flavia Mirela Nicolae, Andrada Soancă, Dorin Nicolae Gheorghe, Dora Maria Popescu, Bogdan Silviu Ungureanu, Dragoș Nicolae Mărgăritescu, Adina Turcu-Știolica, Mihail Virgil Boldeanu, Valeriu Marin Șurlin, Dan Ionuț Gheonea, Petra Șurlin

Journal of Mind and Medical Sciences

Objectives. The present pilot study was carried out to evaluate the periodontal status, the levels of interleukin-6 and tumor necrosis factor alpha in gingival crevicular fluid on hospitalized patients with colorectal cancer. Materials and Methods. The sample of our study was represented by 74 patients with colorectal cancer. They were assigned to one of the two study groups, based on cancer’s stages, as follows: (i) stage III-IV: 51 patients (A-group); (ii) stage I-II: 23 patients (B-group). For each participant periodontal parameters were recorded and gingival crevicular fluid samples were collected and immunologically assessed. Results. Statistically significant differences were found between …

Factors Associated With Periodontitis In Younger Individuals: A Scoping Review, Man Hung, Roah Kelly, Amir Mohajeri, Logan Reese, Sarah Badawi, Taroniar Sevathas, Cole Frost, Martin S. Lipsky

Institute on Aging Publications

Periodontitis is a disease that affects many young adults, and if left untreated, it can have lasting and permanent effects on an individual’s oral health. The purpose of this scoping review was to review the recent literature to identify factors that place young individuals at risk of stage II or III periodontitis. Using the PRISMA guidelines for scoping reviews, three databases were systematically searched for peer-reviewed human studies published in English that investigated risk factors associated with stage II and/or III periodontitis in individuals less than 40 years of age. This review excluded abstracts, literature reviews, including narrative, scoping, and …

Association Between Symptoms Of Severe Periodontitis And Post-Bronchodilator Lung Function: Results From The China Pulmonary Health Study., Zhiqiang Liu, Xuan Zhou, Lirong Liang, Xiaozhe Han, Ting Yang, Kewu Huang, Yingxiang Lin, Zuomin Wang, Chen Wang

HPD Articles

BACKGROUND: The association between periodontitis and post-bronchodilator lung function is unclear. We aimed to determine the associations between symptoms of severe periodontitis (SSP) and post-bronchodilator lung function in the Chinese population.

METHODS: A cross-sectional study (China Pulmonary Health study) was conducted from 2012 to 2015 in a large Chinese nationally representative sample of 49,202 participants aged 20-89 years. Data on demographic characteristics and periodontal symptoms of participants were collected by questionnaire. Participants who had at least one of the two severe symptoms (tooth mobility and natural tooth loss) in the past year were defined to have SSP, which was set …

Low-Level Laser Effects On Orthodontic Tooth Movement Of Periodontally Compromised Patients, Enas H. Abd El-Aziz, Ahmed E. Salama, Osama S. El-Shall, Mohsena A. Abdarazikk

Al-Azhar Journal of Dentistry

Purpose: This study aimed to analyze the Low-Level Laser Therapy (LLLT) effect on periodontal parameters and the pain reduction during canine retraction in patients with compromised periodontium. Subjects and methods: Fourteen patients seeking orthodontic treatment, age ranging from 25-35 years old with compromised periodontium, were selected to participate in the present study. Patients were allocated randomly into two groups, Group I: control group. Group II: test group (LLL application). Bilateral extractions of the mandibular first premolars for all patients were done, then canine retraction was indicated. In laser group, application of LLLT was done on the mandibular anterior segment at …

Neutrophil Apoptosis And Inducible Nitric Oxide Synthase In Type Ii Diabetic Patients With Periodontitis, Romissaa A. Ismail, Naglaa S. Elkilani, Hamdy A. Nassar

Al-Azhar Journal of Dentistry

Purpose: The current study was to evaluate the glycemic status, inducible nitric oxide synthase, and spontaneous neutrophil apoptosis in tested groups which were divided in to four groups; group (1) healthy group, group (2) periodontitis; group (3) diabetic group and group (4) diabetic with periodontitis. Subjects and Methods: There were 40 patients in all, and they were separated into four groups based on their state of health; group (1) healthy, group (2): periodontitis, group (3) type 2 diabetic patients and group (4) diabetic patients with periodontitis. Periodontal parameters, glycemic condition assessment using HbA1c, evaluation of polymorphous neutrophil apoptotic activity using …

Oral Mucosal And Dental Affection In Patients With Systemic Lupus Erythematosus: A Clinical Survey, Omnia A Abubakr, Ali M Youssef, Mohamed A Mohamed, Mohamed A Hamdy

Journal of Medicine in Scientific Research

Background: SLE is a chronic autoimmune disease predominantly affecting young females. Systemic involvement along with variable clinical presentations characterizes SLE. Various oral and dental manifestations have been described in SLE that include oral ulcerations, candida infection, and periodontal disease. We aimed to detect oral mucosal and dental disease in SLE patients and its relation to demographic features, general disease activity, and the extra-articular manifestation. Patients and Methods: 80 patients with SLE were included in this cross-sectional study. Patients were allocated into 2 groups, 40 patients in each group, according to SLE disease control with immunosuppressive medications: group A included patients …

Efficiency Of Hyaluronic Acid Versus Red Injectable Platelet-Rich Fibrin (I-Prf) As An Adjunct To Non-Surgical Treatment Of Stage Iii Periodontitis (Randomized Controlled Clinical Trial), Toleen Mazloum, Ghanem H. Abdullah, Ghassan S. Amhaz, Nayer Aboelsaad

International Arab Journal of Dentistry

Objective: This study aims to compare clinical efficacy of red injectable platelet-rich fibrin (i-PRF) and hyaluronic acid (HA) as adjuncts to professional mechanical plaque removal (PMPR) in non-surgical management of stage III periodontitis. Materials and Methods: 75 patients were split into groups: group one (G1) received HA, group two (G2) received red i-PRF, and group three (G3), received only PMPR. At the baseline, the fourth, eighth-, and twelfth weeks following treatment, the plaque index (PI), gingival index (GI), bleeding on probing (BOP), clinical attachment level (CAL), and probing depth (PD) were all measured. Results: The plaque index, gingival index, and …

Dental And Oral Manifestations Of Rheumatoid Arthritis: Is It Related To General Disease Activity?, Omnia A. Abubakr, Ali M Youssef, Mohamed A Mohamed, Mohamed A Hamdy

Journal of Medicine in Scientific Research

Background: RA is a chronic immune-mediated systemic disorder; its pathogenesis is complex. Genetic, environmental, hormonal, and lifestyle are the main risk factors. The correlation between oral health and RA is rising. Oral manifestations in RA include temporomandibular joint disorder, secondary Sjögren’s syndrome, xerostomia, and periodontal disease. Previous studies suggest a bidirectional relationship between RA and periodontal diseases. This study aims to detect oral mucosal and dental disease in RA patients and its relation to demographic features, disease activity, and extra-articular manifestation. Patients and Methods: This cross-sectional study included 150 patients with RA allocated into two groups, 75 patients in each …

Randomized Control Trial Of A Novel Dental Gel As An Adjunct To Scaling And Root Planing In Subjects With Stage Ii & Iii Periodontitis, Sarah Pham

All ETDs from UAB

The current standard of care for treating chronic periodontitis is scaling and root planing (ScRP) followed by supportive periodontal therapy (SPT) (Cobb et al., 2021; Ramfjord et al., 1987). The goal of ScRP is to eliminate supra- and subgingival bacterial deposits and to reduce periodontal pathogens, inflammation, and pocket depths (Greenstein, 2000). Although ScRP has been shown to significantly improve baseline clinical parameters, moderate to advanced cases may require additional surgical therapy which many patients resist (Stambaugh, 1981; Becker et al., 2001). Currently, no dentifrice used adjunctively has been proven to increase the therapeutic effects of scaling and root planing. …

Histone Acetylation In Periodontal Diseases, Sarang Saadat

Theses and Dissertations

Background: Emerging data has indicated the significant role of epigenetic control in inflammation. Acetylation of lysine residues on histones is a major epigenetic modification of chromatin, which is required for cytokine gene expression and regulated in inflammatory diseases. It has been shown that periodontal bacteria induce histone acetylation in oral epithelial cells and experimental periodontitis in rodents. In this study, we investigated the acetylation level of histone 3 (H3) in gingival tissue from healthy and periodontitis patients. We hypothesize that cytokine over-production in periodontitis is associated with the hyper acetylation of histones. Methods: Periodontitis and healthy subjects who need periodontal …

Oral Health, Dentistry, Periodontology, Interrelation Between Periodontal Disease And Systemic Diseases, Diet And Periodontal Disease, Vijayendra Pandey Dr.

Health collection

There is increasing evidence that Periodontitis is related to a number of systemic diseases and it may be a risk factor for several chronic inflammatory diseases including cardiovascular disease, cerebrovascular disease , angina and myocardial infarction, adverse pregnancy outcomes, respiratory diseases and diabetes mellitus.

Resistin an adipokine found in adipose tissue and also released by inflammatory cells is associated with the upregulation of inflammatory process. Chronic low grade inflammation is emerging as a conceivable etiologic mechanism linking periodontitis and obesity.

Objectives-

To assess whether obese individuals are at increased risk of severe periodontitis by comparing periodontal clinical parameters (GI, PI, …

Orthodontic Treatment In Periodontal Compromised Patient With Class Ii Posterior Cross Bite And Deep Overbite, Chia-Wei Lin, Ellen Wen-Ching Ko

Taiwanese Journal of Orthodontics

Orthodontic management in adult patients with advanced periodontitis is complicated and highly technique sensitive because of missing teeth and reduced alveolar attachment.This case report presents a 32-years old female who was referred from periodontal department, complained about maxillary protrusion and anterior spacing. The diagnoses were Class II division 1 malocclusion, combined with bilateral posterior crossbite and deep overbite. After periodontal inflammation was under well controlled, complicated orthodontic teeth movements were achieved with the aid of TADs. The orthodontic treatment includes the retraction of maxillary anterior teeth and intrusion and palatal movement of upper right segment. In the lower arch, the …

Orthodontic Treatment For A Periodontally Compromised Class Ii Malocclusion - A Case Report, Jiun-Hao Lin, Kuan-Yi Wu, I-Ling Hong, Yi-Jane Chen

Taiwanese Journal of Orthodontics

Adult orthodontic treatment has become increasingly popular. The primary motivating factor for seeking orthodontic treatment in adults is facial and dental esthetics, especially the alignment of their anterior teeth. Pathologic migration of anterior teeth is a common cause of esthetic concern among adult patients. The anchorage control is very important in the orthodontic treatment for the dentition with compromised periodontal support. Mini-implant anchorage provides a good solution to this situation. However, the force level should be light and consistent. Herein we report a 33-year-old female patient who presented a Class II division 1 malocclusion with maxillary anterior crowding, protrusion, and …

10-Minute Ebd: Are Neoplasms A Risk Factor For Peri-Implantitis?, Farah Safieddine Bs, Naama Sleiman Ms, Phd, Melanie E. Mayberry Dds, Ms-Hcm

The Journal of the Michigan Dental Association

This 10-Minute EBD column explores the potential association between neoplasms and the risk of peri-implantitis in patients with dental implants. A case study involving a patient with a history of an ossifying fibroma raises questions about the impact of neoplasms on implant success. The literature search, conducted on PubMed, reveals relevant insights. The evidence suggests that ossifying fibromas, particularly with augmentation, may pose a risk for peri-implantitis. However, the direct causative relationship between neoplasms and peri-implant pathology remains unclear. Other risk factors such as periodontitis, foreign bodies, and augmentation procedures are also discussed in the context of implant complications.

Gingival Transcriptome Of Innate Antimicrobial Factors And The Oral Microbiome With Aging And Periodontitis, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Linh Nguyen, Octavio A. Gonzalez

Center for Oral Health Research Faculty Publications

The epithelial barrier at mucosal sites comprises an important mechanical protective feature of innate immunity, and is intimately involved in communicating signals of infection/tissue damage to inflammatory and immune cells in these local environments. A wide array of antimicrobial factors (AMF) exist at mucosal sites and in secretions that contribute to this innate immunity. A non-human primate model of ligature-induced periodontitis was used to explore characteristics of the antimicrobial factor transcriptome (n = 114 genes) of gingival biopsies in health, initiation and progression of periodontal lesions, and in samples with clinical resolution. Age effects and relationship of AMF to …

The Frequency Of Periodontitis In End-Stage Renal Disease On Hemodialysis In A Sample Of Egyptian Population: Multi-Center Clinical Cross-Sectional Study, Asmaa Ras, Enji A. Ahmed, Radwa Hussein, Eman Khalil

Dentistry

Abstract Background: There is a general assumption that periodontal disease is highly prevalent among patients with chronic renal failure undergoing hemodialysis. The aim of the study to estimate the frequency of periodontitis in patients on hemodialysis among a sample of the Egyptian population, as well as the correlation between different clinical parameters of periodontal status with serum creatinine and blood urea. This may rule out the bidirectional relation‑ ship between periodontitis and renal failure in patients on hemodialysis. Methods: The study was conducted on 263 hemodialysis patients (165 males and 98 females) at three dialysis cent‑ ers in Benha Governorate, …

The Effects Of Clinical Depression On The Oral Health Of College Students, Delorias Perkins, Sarah Peng

Dental Hygiene Student Scholarship

Objectives: Mental health among college students has become a recent concern due to the rising cases of depression. In addition to the stress factors a typical college student often faces, we now have the COVID-19 pandemic that further exacerbates this issue. One’s state of mind has a significant impact on not only their mindset but their body overall. If the body’s health is impacted by depression, then it will influence the immune system and bodily function, ultimately affecting the oral cavity as well. The purpose of this review of literature is to identify the relationship between clinically diagnosed depression and …

Who's Included? A Systematic Review Of Socio-Demographics And Participant Recruitment Within The Investigation Of Periodontal Disease And Its Treatment Effect On Hemoglobin A1c, Jaclyn L. Johnson

All Master's Theses

Diabetes mellitus and periodontal disease are major global public health concerns. Within the United States (U.S.) over 34 million adults have diagnosed diabetes (Centers for Disease Control and Prevention [CDC], 2020a), and 64 million U.S. adults have periodontitis (American Academy of Periodontology [AAP], 2021a). Research has shown that persons with diabetes have a coinfection with periodontal disease at a rate between 2.6 and 2.9 times higher than persons without diabetes (Wang et al., 2014). Diabetes and periodontal disease collectively and disproportionately affect persons of low socioeconomic status (SES), age, and particular racial/ethnic identities (AAP, n.d.b; CDC, 2021; Connolly et al., …

The Frequency Of Periodontitis In End‑Stage Renal Disease On Hemodialysis In A Sample Of Egyptian Population: Multi‑Center Clinical Cross‑Sectional Study, Enji Ahmed Mahmoud, Asmaa Abobakr, Eman Khalil, Radwa Raghib

Dentistry

Background: There is a general assumption that periodontal disease is highly prevalent among patients with chronic renal failure undergoing hemodialysis. The aim of the study to estimate the frequency of periodontitis in patients on hemodialysis among a sample of the Egyptian population, as well as the correlation between different clinical parameters of periodontal status with serum creatinine and blood urea. This may rule out the bidirectional relationship between periodontitis and renal failure in patients on hemodialysis. Methods: The study was conducted on 263 hemodialysis patients (165 males and 98 females) at three dialysis centers in Benha Governorate, Egypt (Benha Hospital, …

Evaluation Of Locally Delivered 1.2% Atorvastatin Gel Versus 2% Melatonin Gel As Adjunctive To Non-Surgical Periodontal Therapy On Gcf Osteocalcin Level In Stage Ii Periodontitis Patients: A Randomized Controlled Trial, Sarah Gamal Moussa

Future Dental Journal

Abstract:

Objective: Atorvastatin (ATV) and melatonin have antioxidant and anti-inflammatory properties and were suggested to have positive effects when used in periodontitis cases. In periodontitis, osteocalcin (OC) was suggested to be a bone formation marker. Regarding bone turnover in periodontium, gingival crevicular fluid (GCF) osteocalcin levels are more accurate than salivary or serum levels.

Aim: The aim of the present study was to assess the effectiveness of local delivery of ATV gel and melatonin gel as adjuncts to scaling and root planing (SRP) in the treatment of stage II periodontitis patients.

Subjects and method: Thirty-six patients having stage II periodontitis …

Oral Microbiome And Gingival Gene Expression Of Inflammatory Biomolecules With Aging And Periodontitis, Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha S. Kirakodu, Octavio A. Gonzalez

Center for Oral Health Research Faculty Publications

Although data describe the presence and increase of inflammatory mediators in the local environment in periodontitis vs. health in humans, details regarding how these responses evolve in the transition from health to disease, changes during disease progression, and features of a resolved lesion remain unknown. This study used a nonhuman primate model of ligature-induced periodontitis in young, adolescent, adult, and aged animals to document features of inflammatory response affected by age. Rhesus monkeys had ligatures tied and provided gingival tissue biopsy specimens at baseline, 0.5, 1, and 3 months of disease and at 5 months of the study, which was …

The Effect Of Locally Applied Simvastatin On Clinical Attachment Level And Alveolar Bone In Periodontal Maintenance Patients, Lauren Krell

Theses & Dissertations

The purpose of this double-blinded, randomized, controlled trial was to determine if the local application of simvastatin (SIM), combined with minimally invasive papilla reflection and root preparation (PR/RP), is effective in improving clinical attachment level (CAL), primary outcome measure; probing depth (PD) reduction; increasing interproximal bone height (IBH); and reducing bleeding on probing (BOP) in persistent 6-9 mm periodontal pockets in patients receiving periodontal maintenance therapy (PMT). Fifty patients with Stage III, Grade B periodontitis (AAP, 2018) presenting with a 6-9 mm interproximal PD with a history of bleeding on probing (BOP) were included in the study. Experimental 2.2 mg …