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Differential Spectrophotometric Analysis Of Intravenous Admixtures Containing Metaraminol With Selected Corticosteroids, Frederick Erin Turner

University of the Pacific Theses and Dissertations

Intravenous admixtures consisting of one or more drug formulations, diluted in a large volume of intravenous solution, are used extensively in current medical practice. Development of reliable methods to predict the compatibility of the admixture components is essential as a guide for their selection.

Because the majority of the reports published, to date, have used a visible change as the criterion for judging compatibility, it was the purpose of this study to demonstrate the use of spectrophotometric analysis to detect the occurrence of chemical interactions between two components of an intravenous admixture.