Digital Commons Network^™

The Developmental Importance Of Napping In Preschool Children, Adam T. Newton

Electronic Thesis and Dissertation Repository

Most children cease napping between 2- and 5-years-old. Little is known about the predictors or outcomes related to this cessation, or the interrelation of different components of nap behavior. Four empirical studies were conducted to investigate the developmental importance of napping among preschool children.

Studies 1 and 2 used a large, longitudinal sample of Canadian children to investigate the predictors (Study 1) and outcomes (Study 2) related to early nap cessation. Early nap cessation was defined as stopping daytime sleep before three years old. In Study 1, parents reported on their own, child, and family functioning at two timepoints (0-1 …

Examining The Relationships Between Socio-Cognitive Factors And Neural Synchrony During Movie Watching Across Development, Kathleen M. Lyons

Electronic Thesis and Dissertation Repository

While different cognitive abilities mature, the conscious experiences of children likely become richer and more elaborate. A challenge in investigating relationships between cognitive development and real-world experiences is having measures that assess naturalistic processing. Movie watching offers a solution, since following the plot of a film requires cognitive processes that are similar to real-world experiences. When different adults watch the same film, their brain activity begins to align (known as neural synchrony). The strength of this alignment has been shown to reflect the degree to which different individuals are having a similar experience of the movie. While this phenomenon has …

Sustainable Development Goals Within Canadian Universities, Kavanagh S.A Lambert

Undergraduate Student Research Internships Conference

The 17 Sustainable Development Goals (SDGs) were created for all countries by the United Nations in 2015 with the aim of transforming the world for the better. Each country is responsible for working towards achieving these SDGs. Within Canada, fifteen research universities known as the U-15 make up the majority of private-sector research and innovation. About 65% of these U-15 institutions have developed their own SDG report/plan, illustrating a high level of initiative and involvement when it comes to the SDGs. Research indicates that as countries continue to improve their efforts towards the SDGs, there will be a need for …

Developmental Differences In The Learning And Consolidation Of Linguistic Regularities, Sarah Berger

Electronic Thesis and Dissertation Repository

Relative to adults, children have a well-known advantage for learning linguistic regularities, which could be partially driven by their deeper sleep. To examine the relationship between consolidation and language learning across development, children and adults learned a novel article system with an implicit grammatical rule. Participants performed a judgment task on phrases containing the novel articles before and after a night of EEG-monitored sleep. We found that rule sensitivity emerged rapidly in children, whereas it did not emerge until the second session in adults. Children demonstrated better generalization of the rule than adults. Consolidation effects showed a developmental double dissociation, …

Dissolving Nature/Nurture: Development As Coupled Interaction, Derek E. Oswick

Electronic Thesis and Dissertation Repository

For many, the Nature/Nurture approach to development is a quaint figment of the past. We have moved on, one might think; everyone thinks that both categories are important for development, not merely one. The reality, however, is not so simple. In this dissertation, I argue that contemporary biology has not succeeded in getting out from under the shadow of Nature/Nurture, despite everyone being some sort of interactionist about development. The central aim of my project is to offer a form of developmental interactionism worth having, which succeeds in shedding the pernicious aspects of Nature/Nurture. I begin by giving an overview …

A Novel Mistranslating Trna Model In Drosophila Melanogaster Has Diverse, Sexually Dimorphic Effects, Joshua R. Isaacson, Matthew D. Berg, Brendan Charles, Jessica Jagiello, Judit Villén, Christopher J. Brandl, Amanda J. Moehring

Neuroscience Institute Publications

Transfer RNAs (tRNAs) are the adaptor molecules required for reading the genetic code and producing proteins. Transfer RNA variants can lead to genome-wide mistranslation, the misincorporation of amino acids not specified by the standard genetic code into nascent proteins. While genome sequencing has identified putative mistranslating transfer RNA variants in human populations, little is known regarding how mistranslation affects multicellular organisms. Here, we create a multicellular model of mistranslation by integrating a serine transfer RNA variant that mistranslates serine for proline (tRNAUGG,G26ASer) into the Drosophila melanogaster genome. We confirm mistranslation via mass spectrometry and find that tRNAUGG,G26ASer misincorporates serine for …

Spatiotemporal Characterization Of The Prr12 Paralogues In Zebrafish, Renee Jeannine Resendes

Electronic Thesis and Dissertation Repository

Pathogenic variants in the human PRR12 (Proline Rich 12) gene are associated with PRR12-related Neuroocular Syndrome. However, little is known about the gene/protein function. The zebrafish was utilized to address this, as its attributes place it as a premier model to study genes involved in human development and disease. In situ hybridization and RT-PCR of embryos and larvae, and qRT-PCR of adult tissues revealed the spatial and temporal distributions of the prr12 paralogues: prr12a and prr12b. Both paralogues were detected from the maternal and zygotic transcriptomes in a global and diffuse expression pattern, and there was enrichment …

Mother-Child Similarity In Brain Morphology: A Comparison Of Structural Characteristics Of The Brain's Reading Network, Lynn V. Fehlbaum, Lien Peters, Plamina Dimanova, Margot Roell, Réka Borbás, Daniel Ansari, Nora M. Raschle

Paediatrics Publications

Background: Substantial evidence acknowledges the complex gene-environment interplay impacting brain development and learning. Intergenerational neuroimaging allows the assessment of familial transfer effects on brain structure, function and behavior by investigating neural similarity in caregiver-child dyads. Methods: Neural similarity in the human reading network was assessed through well-used measures of brain structure (i.e., surface area (SA), gyrification (lG), sulcal morphology, gray matter volume (GMV) and cortical thickness (CT)) in 69 mother-child dyads (children's age~11 y). Regions of interest for the reading network included left-hemispheric inferior frontal gyrus, inferior parietal lobe and fusiform gyrus. Mother-child similarity was quantified by correlation coefficients and …

Approaches To Examining The Role Of Auditory Evoked Potentials In Early Language Development, Alyssa Janes

Electronic Thesis and Dissertation Repository

Previous research has suggested a relationship between auditory evoked potentials (AEPs) and spoken language proficiency, but their interactions during the earliest stages of development are not well understood. AEP-Age, an index that estimates the maturity of a child’s AEP relative to same-aged peers, has been effective in investigating this relationship in school-aged children, but has yet to be applied to younger populations. This thesis includes two Stage 1 Manuscripts (Registered Reports) for future studies to (a) assess the utility of AEP-Age to predict chronological age and language ability in 18-48-month-old children, and (b) investigate the relationship between AEP-Age and …