Digital Commons Network^™

Field Testing Of Collection Cards For Cannabis Sativa Samples With A Single Hexanucleotide Dna Marker, Lindsey Allgeier, John Hemenway, Nicholas Shirley, Tommy Lanier, Heather Miller Coyle

Forensic Science Publications

Abstract:  The validity and feasibility of using DNA collection cards in the field for preservation and analysis of Cannabis sativa genotypes were investigated using a highly specific hexanucleotide marker. Collection cards were submitted to the National Marijuana Initiative, which selectively trained and managed the collection of specific types of samples from a variety of participating agencies. Samples collected at seizure sites included fresh marijuana leaf samples, dried “dispensary” samples, U.S. border seizures, and hashish. Using a standardized PCR kit with custom-labeled oligonucleotide primers specific to marijuana, collection cards produced eight genotypes and 13 different alleles, extremely low baselines, and no …

Cerebellar White-Matter Changes In Cannabis Users With And Without Schizophrenia, N Solowij, M Yucel, C Respondek, S Whittle, E Lindsay, C Pantelis, D I. Lubman

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background. The cerebellum is rich in cannabinoid receptors and implicated in the neuropathology of schizophrenia. Long-term cannabis use is associated with functional and structural brain changes similar to those evident in schizophrenia, yet its impact on cerebellar structure has not been determined. We examined cerebellar grey and white matter in cannabis users with and without schizophrenia. Method. Seventeen patients with schizophrenia and 31 healthy controls were recruited ; 48% of the healthy group and 47% of the patients were long-term heavy cannabis users (mean 19.7 and 17.9 years near daily use respectively). Cerebellar measures were extracted from structural 3-T magnetic …

Verbal Learning And Memory In Adolescent Cannabis Users, Alcohol Users And Non-Users, Nadia Solowij, Katy A. Jones, Megan E. Rozman, Sasha M. Davis, Joseph Ciarrochi, Patrick C. L Heaven, Dan I. Lubman, Murat Yucel

Faculty of Health and Behavioural Sciences - Papers (Archive)

Rationale Long-term heavy cannabis use can result in memory impairment. Adolescent users may be especially vulnerable to the adverse neurocognitive effects of cannabis. Objectives and methods In a cross-sectional and prospective neuropsychological study of 181 adolescents aged 16–20 (mean 18.3 years), we compared performance indices from one of the most widely used measures of learning and memory—the Rey Auditory Verbal Learning Test—between cannabis users (n=52; mean 2.4 years of use, 14 days/month, median abstinence 20.3 h), alcohol users (n=67) and non-user controls (n=62) matched for age, education and premorbid intellectual ability (assessed prospectively), and alcohol consumption for cannabis and alcohol …

A Critical Appraisal Of The Department Of Justice's New Approach To Medical Marijuana, Robert A. Mikos

Vanderbilt Law School Faculty Publications

The Obama Administration has embarked upon a much-heralded shift in federal policy toward medical marijuana. Eschewing the hard-ball tactics favored by earlier Administrations, Attorney General Eric Holder announced in October 2009 that the Department of Justice (DOJ) would stop enforcing the federal marijuana ban against persons who comply with state medical marijuana laws. Given the significance of the medical marijuana issue in both criminal law and federalism circles, this Article sets out to provide the first in-depth analysis of the changes wrought by the DOJ’s new Non Enforcement Policy (NEP). In a nutshell, it suggests that early enthusiasm for the …

Cannabis And Cognition: Short- And Long-Term Effects, Nadia Solowij, Nicole Pesa

Faculty of Health and Behavioural Sciences - Papers (Archive)

Twenty years ago cannabis was generally perceived to be a benign drug with few significant adverse effects. As outlined elsewhere in this book, evidence has since mounted in the scientific literature for a range of harms associated with the use of cannabis, including the development of dependence and health-related harms (see also Hall and Solowij, 1998; Hall and Degenhardt, 2009). As the overall theme of this book indicates, an association between cannabis use and the development of psychotic symptoms or overt psychosis has grown to be recognized as a significant potential harm, and investigating the mechanisms by which cannabis may …

Commenting On Cannabis: Testing News Fragmentation Using Reader Comments On California's Proposition 19, John D. Beecham

College of Journalism and Mass Communications: Theses

This content analysis studies reader comments on news articles pertaining to the issue of California’s Proposition 19—the “Tax Cannabis Initiative” to legalize marijuana. It investigates whether these reader message boards are consistent with news fragmentation theory, by examining whether the distribution of “yes” and “no” opinion on alternative media sites’ message boards is more homogenous than the distribution of opinions on mainstream news sites’ message boards. This study also uses a thematic analysis to investigate whether the mainstream media, as represented by editorial board endorsements by daily California newspapers, influences themes used by reader comments on Proposition 19. Results show …

One Toke Over The Line: The Proliferation Of State Medical Marijuana Laws, Troy E. Grandel

The University of New Hampshire Law Review

[Excerpt] “Marijuana has been used for medicinal purposes for at least five thousand years. In fact, it was used medicinally in the United States up until the twentieth century when antidrug zealots managed to prohibit it. Prohibition was the status quo until 1996 when California became the first state to adopt a law allowing medicinal marijuana use. Since then, thirteen additional states, along with the District of Columbia, have enacted similar laws. More states are now lining up with their own laws, which are in various stages of adoption. In addition, the Supreme Court has impacted the issue, both with …

Neuropsychological Performance In Cannabis Users And Non-Users Following Motivation Manipulation, Michelle Stiles

Psychology

Background: Previous research has yielded conflicting results regarding the long term consequences of cannabis use on cognitive functioning. Although in the cannabis literature, there is a commonly held belief associated with cannabis use called, “amotivational syndrome” the authors were unable to find any studies of neuropsychological performance that attempted to manipulate motivation. Methods: Fifty-five undergraduates (34 cannabis users and 21 non-users) participated in an extensive neuropsychological battery. The experimenter read a statement at the beginning of the battery designed to induce motivation. Group differences on test performance were calculated with a one-way analysis of variance (ANOVA) for tests that did …

Differential Roles Of The Two Major Endocannabinoid Hydrolyzing Enzymes In Cannabinoid Receptor Tolerance And Somatic Withdrawal, Joel Schlosburg

Theses and Dissertations

While there is currently active debate over possible therapeutic applications of marijuana and cannabis-based compounds, consistently their primary drawbacks have been the psychoactive properties, dependence, and abuse potential. Prolonged administration of ∆9-tetrahydrocannabinol (THC), the primary psychoactive constituent in marijuana, demonstrates both tolerance and physical withdrawal in both preclinical and clinical studies. Repeated THC administration also produces CB1 receptor adaptations in the form of reduced activation of receptors, along with a downregulation of membrane surface receptors, in many brain regions involved in THC-associated behaviors. The increased need for drug to maintain therapeutic effects, and a withdrawal syndrome following discontinuation of use, …

Cognitive Abnormalities And Cannabis Use, Nadia Solowij, Nicole Pesa

Faculty of Health and Behavioural Sciences - Papers (Archive)

OBJECTIVE: Evidence that cannabis use impairs cognitive function in humans has been accumulating in recent decades. The purpose of this overview is to update knowledge in this area with new findings from the most recent literature. METHOD: Literature searches were conducted using the Web of Science database up to February 2010. The terms searched were: "cannabi*" or "marijuana", and "cogniti*" or "memory" or "attention" or "executive function", and human studies were reviewed preferentially over the animal literature. DISCUSSION: Cannabis use impairs memory, attention, inhibitory control, executive functions and decision making, both during the period of acute intoxication and beyond, persisting …

Harms To Body And Soul: An Ideological Balancing Act For Preventing And Reducing Cannabis Use, Nadia Solowij

Faculty of Health and Behavioural Sciences - Papers (Archive)

In their piece for debate, Macleod & Hickman [1] present some credible arguments around the ways in which ideology may shape evidence and policy and describe the inevitable use of select aspects of scientific evidence to advance an agenda and drive funding directions. While the strength of evidence regarding causality in the association between cannabis and schizophrenia may not be incontrovertible, some of their arguments are indeed driven by their own ideology and advancement of their proposition that the main harmassociated with cannabis use pertains to its intimate relation to tobacco use, and that this, and the development of dependence, …

The Neuropsychological Deficits In Cannabis Users : Does Motivation Play A Role?, Rayna Beth Ericson

Legacy Theses & Dissertations (2009 - 2024)

Prior research of the neuropsychological functioning of cannabis users has yielded mixed results, in that some studies identified differences compared to non-users, while others found no group differences at all. A meta-analysis revealed a small effect of cannabis use on the cognitive domains of learning and forgetting, while domains such as attention and processing speed yielded no effect (Grant et al., 2003). However, none of the previous studies assessed the participants' motivation to perform well on the assessment, which may have influenced the results. The present study sought to determine whether motivation is differentially demonstrated in cannabis users compared to …

Effects Of Cannabinoid Receptor Interacting Protein (Crip1a) On Cannabinoid Receptor (Cb1) Function, Tricia Smith

Theses and Dissertations

EFFECTS OF CANNABINOID RECEPTOR INTERACTING PROTEIN (CRIP1a) ON CANNABINOID (CB1) RECEPTOR FUNCTION. By Tricia Hardt Smith, B.S., M.S. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University Virginia Commonwealth University, 2009. Major Director: Dana E. Selley, Ph.D., Department of Pharmacology and Toxicology This dissertation examines modulation of cannabinoid CB1 receptor function by Cannabinoid Receptor Interacting Protein (CRIP1a), a novel protein that binds the C-terminus of CB1 receptors. In Human embryonic kidney cells expressing human CB1 receptors (hCB1-HEK) and hCB1-HEK cells stably co-expressing CRIP1a (hCB1-HEK-CRIP1a), quantitative immunoblotting revealed a CRIP1a/CB1 …

Cannabis & Psychosis: The Interface Emerging Frontiers For Research, Amresh Shrivastava

Amresh Srivastava

INTRODUCTION: CANNABIS CONTINUES TO AFFECT MENTAL HEALTH. ITS ABUSE IS ON RISE GLOBALLY. IN CANADA A RISE BY 30% IN LAST TEN YEARS HAS BEEN OBSERVED IN HIGH SCHOOL STUDENTS. INTERRELATIONSHIP OF CANNABIS WITH PSYCHOSIS AND SCHIZOPHRENIA IS A COMPLEX ONE. CANNABIS IS HIGHLY COMORBID WITH PSYCHOSIS, & RELATED TO FUNCTIONAL DISABILITY AND OUTCOME. IT POSES SEVERAL CHALLENGES IN UNDERSTANDING CAUSAL RELATIONSHIP FOR COMORBIDITY, UNDERLYING NEUROCHEMICAL BASIS AND SPECIFICS OF SERVICE DEVELOPMENT. PREVALENCE OF CANNABIS VARIES FROM 20 TO 50% EARLY PSYCHOSIS. OBJECTIVE OF THIS PAPER IS TO REVIEW AVAILABLE LITERATURE TO IDENTIFY CHALLENGES FOR NEWER TARGETS OF RESEARCH AND …

Interface Of Cannabis And Early Psychosis--Priorities In Research And Service Development, Amresh Srivastava

Amresh Srivastava

Introduction: cannabis continues to affect mental health. Its abuse is on rise globally. In Canada a rise by 30% in last ten years has been observed in high school students. Interrelationship of cannabis with psychosis and schizophrenia is a complex one. Cannabis is highly comorbid with psychosis, & related to functional disability and outcome. It poses several challenges in understanding causal relationship for comorbidity, underlying neurochemical basis and specifics of service development. Prevalence of Cannabis varies from 20 to 50% early psychosis. Objective of this paper is to review available literature to identify challenges for newer targets of research and …

Guide D'Aide A L'Arret Du Cannabis (Guide To Quitting Cannabis), B. F. S. Grenyer, Nadia Solowij, R Peters

Illawarra Health and Medical Research Institute

Ce guide a pour objectif d’aider les personnes qui envisagent d’arrêter de consommer du cannabis. Il peut aussi apporter des informations utiles à des personnes qui n’éprouvent pas actuellement le besoin d’arrêter. Il vous accompagnera de manière pratique, au long des différentes étapes du processus d’arrêt. Il vous aidera à identifi er les motivations qui vous poussent à consommer, les circonstances dans lesquelles vous fumez, mais également les raisons qui vous incitent à arrêter.

Interface Of Cannabis And Early Psychosis--Priorities In Research And Service Development, Amresh Srivastava

Psychiatry Presentations

Introduction: cannabis continues to affect mental health. Its abuse is on rise globally. In Canada a rise by 30% in last ten years has been observed in high school students. Interrelationship of cannabis with psychosis and schizophrenia is a complex one. Cannabis is highly comorbid with psychosis, & related to functional disability and outcome. It poses several challenges in understanding causal relationship for comorbidity, underlying neurochemical basis and specifics of service development. Prevalence of Cannabis varies from 20 to 50% early psychosis. Objective of this paper is to review available literature to identify challenges for newer targets of research and …

Cannabis & Psychosis: The Interface Emerging Frontiers For Research, Amresh Shrivastava

Psychiatry Presentations

INTRODUCTION: CANNABIS CONTINUES TO AFFECT MENTAL HEALTH. ITS ABUSE IS ON RISE GLOBALLY. IN CANADA A RISE BY 30% IN LAST TEN YEARS HAS BEEN OBSERVED IN HIGH SCHOOL STUDENTS. INTERRELATIONSHIP OF CANNABIS WITH PSYCHOSIS AND SCHIZOPHRENIA IS A COMPLEX ONE. CANNABIS IS HIGHLY COMORBID WITH PSYCHOSIS, & RELATED TO FUNCTIONAL DISABILITY AND OUTCOME. IT POSES SEVERAL CHALLENGES IN UNDERSTANDING CAUSAL RELATIONSHIP FOR COMORBIDITY, UNDERLYING NEUROCHEMICAL BASIS AND SPECIFICS OF SERVICE DEVELOPMENT. PREVALENCE OF CANNABIS VARIES FROM 20 TO 50% EARLY PSYCHOSIS. OBJECTIVE OF THIS PAPER IS TO REVIEW AVAILABLE LITERATURE TO IDENTIFY CHALLENGES FOR NEWER TARGETS OF RESEARCH AND …

Analysis Of Residue In Pipes That Were Smoked By Prehistoric North American Indians In The States And Portions Of Canada East Of The Mississippi, Tommy Charles

Faculty & Staff Publications

No abstract provided.

Personality And Cannabis Use, Emma Barkus

Faculty of Health and Behavioural Sciences - Papers (Archive)

Cannabis is one of the most widely used illegal substances in the world. Its use has been reported to be over-represented in many psychiatric conditions and has frequently been found to predate the onset of psychiatric symptoms. However, cannabis may also have detrimental effects on the general population. Factors that predict the onset of use are receiving increased attention to aid in identifying groups of young people who may be more prone to consume cannabis. Personality traits may be one such factor as they are readily identifiable and offer information that can be used for improved targeting of educational material …

Cannabis-Induced Psychotic-Like Experiences Are Predicted By High Schizotypy. Confirmation Of Preliminary Results In A Large Cohort., John Stirling, Emma Barkus, L Nabosi, S Irshad, G Roemer, B Schreudergoidheijt, Shon Lewis

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background: Cannabis use has been identified as a possible risk factor for developing schizophrenia. In a previous paper we reported preliminary evidence that cannabis use increases the likelihood of psychosis-like experiences in non-clinical respondents who scored highly on a measure of schizotypy. We now present findings from pooled data from 3 new follow-up studies comprising a sample of 477 respondents, of whom 332 reported using cannabis at least once. Sampling and Methods: As in our previous study, the psychological effects of cannabis were assessed with the Cannabis Experiences Questionnaire, from which 3 subscales can be derived; encompassing pleasurable experiences, psychosis-like …

Visuospatial Memory Deficits In Long Term Heavy Cannabis Users: Relation To Psychotic Symptoms And Regional Brain Volumes, Nadia Solowij, Colleen Respondek, Robert A. Battisti, Sarah Whittle, Daniel Dr Daniel Lubman, Murat Yucel

Faculty of Social Sciences - Papers (Archive)

Abstract from the XXVI CINP Congress, Munich, 13-17 July 2008

Cannabinoid Modulation Of Microglial Activation In Multiple Sclerosis, Natalie Shea Lemons

Honors Theses

Multiple Sclerosis (MS) is a neurodegenerative disease that is estimated to affect 400,000 Americans. There is no cure for MS and some treatments at this point are toxic to patients. Dr. Lori Hensley's lab is researching two drugs that could potentially be used to treat MS without toxic effects. Previous work in the lab shows ajulemic acid, a synthetic molecule similar to metabolites from the cannabis plant, selectively suppresses markers of the inflammatory response. worked on the mechanism of ajulemic acid's action by investigating the roles of several candidate receptors in mediating these observed effects.

Schizotypy And Psychosis-Like Experiences From Recreational Cannabis In A Non-Clinical Sample, Emma Barkus, Shon Lewis

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background. The relationship between cannabis use and psychosis is still a matter for debate. Accounting for the individual differences in subjective experiences to recreational cannabis use in the general population may hold some clues to the aetiological relationship between cannabis and psychotic symptoms. We hypothesized that schizotypy would account for the individual differences in subjective experiences after cannabis use but not in patterns of use. Method. In a sample of 532 young people who had used cannabis at least once, we examined the relationship between the Cannabis Experiences Questionnaire (CEQ) and the Schizotypal Personality Questionnaire (SPQ). Additionally, we examined the …

Cannabis-Induced Psychosis-Like Experiences Are Associated With High Schizotypy, Emma Barkus, John Stirling, Richard Hopkins, Shon Lewis

Faculty of Health and Behavioural Sciences - Papers (Archive)

OBJECTIVE: Recent studies have suggested that cannabis use is a risk factor for developing schizophrenia. We tested the hypothesis that cannabis use increases the likelihood of psychosis-like experiences in non-clinical participants who scored highly on a measure of schizotypy. METHOD: The psychological effects of cannabis were assessed in 137 healthy individuals (76% female, mean age 22 years) using a newly developed questionnaire concerned with subjective experiences of the drug: the Cannabis Experiences Questionnaire. The questionnaire has three subscales: Pleasurable Experiences, Psychosis-Like Experiences and After-Effects. Respondents also completed the brief Schizotypal Personality Questionnaire. RESULTS: Cannabis use was reported by 72% of …

Supportive-Expressive Psychotherapy For Cannabis Dependence, Brin F. Grenyer, Nadia Solowij

Faculty of Health and Behavioural Sciences - Papers (Archive)

Supportive–expressive (SE) dynamic psychotherapy forms one variation of a number of psychotherapies that emphasize the importance of effective interpersonal relationships for psychological health (Grenyer, 2002a). The overall goal of SE psychotherapy is to help the client achieve mastery over their difficulties, gain self-understanding, and practice self-control over habitual drug use and related problems. From this framework, cannabis dependence is understood within the context of the client's interpersonal relationships, work, and social problems. The theory behind the SE approach emphasizes the formative influence of life experiences on the development of personality and on the genesis of problems, including habitual cannabis use. …

The Adverse Health And Psychological Consequences Of Cannabis Dependence, Wayne Hall, Nadia Solowij

Faculty of Health and Behavioural Sciences - Papers (Archive)

People who become dependent on cannabis are more likely than infrequent users to experience any of the adverse health effects that are caused by chronic cannabis use. Dependent cannabis use is rare in comparison with the more prevalent pattern of experimental and intermittent use (Bachman et al., 1997), but it may nonetheless affect as many as 1% of adults in the USA and Australia in any 1 year (Anthony et al., 1994; Hall et al., 1999a). Dependent cannabis users typically smoke two or more cannabis cigarettes a day over periods of years or decades in a minority …

Cannabis And Cognitive Function: Relevant To Psychosis, Nadia Solowij

Faculty of Social Sciences - Papers (Archive)

Abstract from 'Brainwaves'- The Australasian Society for Psychiatric Research Annual Meeting 2006, 6-8 December, Sydney, Australia

Outcome Evaluation Of The School Drug Education Project: Final Report Presented To The School Drug Education And Road Aware Project, Therese Shaw, Margaret Hall, Donna Cross, Hamilton Greg

Research outputs pre 2011

In 2002, Curtin University's Western Australian Centre for Health Promotion Research provided a report which explored the feasibility of a range of options to evaluate the impact of the School Drug Education Project (SDEP) on students' drug use, perceptions of drug-related harm and attitudes towards drug use. Given the difficulties of achieving a prospective design, this proposal recommended comparing retrospective measures of SDEP participation, level of SDEP training and dose of SDEP implementation with Years 8-12 student drug-related outcome data collected from four large Western Australian studies conducted somewhat concurrently with the School Drug Education Project.

It was hypothesised that …

Effect Of Repeated Dosing Of Delta 9-Tetrahydrocannabinol, The Major Psychoactive Ingredient Of Marijuana, On Memory In Mice, Floride Niyuhire

Theses and Dissertations

Purpose: Marijuana is the most widely used illicit drug in the United States. However, marijuana and cannabinoid derivatives have potential therapeutic uses. Studies in cannabis users have yielded contradictory results with regard to long-term effects on cognitive functions. There is no prospective study assessing this issue, and such studies may raise ethical issues in humans, whereas mice have been shown to exhibit similar cannabinoid-mediated behaviors as humans. The purpose of this study was to assess the consequences of chronic administration of Δ9-THC, the major psychoactive component of marijuana, in a mouse memory model. Methods: In Experiment 1, the dose-response relationship …