Digital Commons Network^™

The Role Of Gadd45b In Hippocampus-Dependent Cognition, Synaptic Plasticity And Activity-Associated Transcriptional Dynamics, Faraz Sultan

All ETDs from UAB

An expanding body of literature argues for a pivotal role of molecular epigenetic mechanisms in memory. Defined as mechanisms that regulate gene expression in the absence of DNA sequence modifications, these regulate various stages of memory-associated transcription. These phenomena are present at diverse anatomical subregions of the central nervous system (CNS) and regulate corresponding behaviors. Epigenetic mechanisms comprise a unique category of behavioral and physiological modulators because of their potential to modify the cellular phenotype in a stable manner. Hence, epigenetics offers a novel potential solution to a central paradox in memory retention: the finding that most putative molecular substrates …

Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber

Psychology Faculty Research and Publications

Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer's disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD. Unfortunately, treatments aimed at improving clinical symptoms or markers of brain function generally have been of limited value. Physical exercise is often recommended for people diagnosed with MCI, primarily because of its widely reported cognitive benefits in healthy older adults. However, it is unknown if exercise actually benefits brain function during memory retrieval in MCI. Here, we examined the effects of exercise training on semantic memory activation during functional magnetic resonance imaging (fMRI). Seventeen MCI participants …

Grounding The Counterculture: Post-Modernism, The Back-To-The-Land Movement, And Authentic Enviroments Of Memory, Jonathan Bowdler

Electronic Theses and Dissertations

This thesis will explore the regional and cultural dimensions of the Back-to-the-Land movement during the 1970s in an effort to move scholarship away from applying theoretical constructs such as post-modernism to diverse social movements. By drawing on the three main Back-to-the-Land publications, namely the Whole Earth Catalog, Mother Earth News, and the Foxfire books, this paper will demonstrate the varying impulses and regional nuances of the movement as well as the continuity and discontinuity of the back-to-nature tradition in America. Particular emphasis will be placed on the ways in which the Southern homesteading experience has been masked within the scholarship …

Intrinsic And Extrinsic Factors Required For Cd4 T Memory Cell Formation And Function, Sarah B. Mollo

All ETDs from UAB

CD4 T cells are central to the organization of the immune response through the secretion of cytokines that recruit and activate other immune cells. Following infection and pathogen control, the majority of the effector CD4 T cells undergo apoptosis, leaving a subset that persists and gives rise to the memory T cell pool. Upon encountering the same pathogen, memory CD4 T cells respond rapidly, providing enhanced protection from re-infection. What determines which effector CD4 T cells will survive is unclear; however, there are a number of factors both intrinsic to the cell as well as external signals from the environment …

Epigenetic Regulation Of Hippocampus-Dependent Learning, Laura Qadri

All ETDs from UAB

Knowledge of the molecular mechanisms that underlie learning and memory has advanced a great deal. Research into the role of epigenetics, or modifications above the genome, has the promise of providing an even greater understanding of the precise mechanisms involved in memory formation. Studies of epigenetic regulation of memory in the rodent hippocampus have primarily focused on associative learning using contextual fear conditioning. While these studies have provided valuable insight into the role that epigenetics plays in cognition, it remains to be seen whether the findings generalize to other forms of hippocampus-dependent learning. This work examines the role of epigenetic …

Regulation Of Alpha Synuclein Following Chronic Methamphetamine Administration In Guinea Pigs: Correlation With Memory And Synaptic Plasticity, Adnouse Blanc

PCOM Biomedical Studies Student Scholarship

Methamphetamine (METH) is a highly addictive drug of abuse that has a severe impact on neuronal changes in the brain including modulations of plasticity, cognitive dysfunction, as well as memory impairment. These changes can be seen as modifications in the expression of biochemical markers associated with synaptic plasticity. One such marker associated with memory impairment is alpha synuclein (α-syn). Alteration of α-syn expression has been linked to memory impairment in patients with Alzheimer’s disease (AD) and Parkinson’s disease (PD). Here we assess the effect of chronic METH treatment in correlation to cognitive functions.

Twenty-nine guinea pigs (male, 150-250 g) were …

Woman Trouble: True Love And Homecoming In Pedro Almodóvar's Volver (2006), Corinne Ondine Pache

Classical Studies Faculty Research

A meditation on the notion of return, Pedro Almodóvar's 2006 Volver focuses on the modern experience of love, memory, and identity in a manner that is at once indebted to the past and resolutely contemporary. Some films represent the ancient world directly, drawing on historical or literary sources, but many that focus on contemporary narratives can be shown to be inspired—directly or not—by ancient myths whose history is so influential that they pervade many of our notions about the human experience. In particular, insofar as Homer's poem is the foundational text in Western culture of the very idea of homecoming—or …

Constructing A Kazak Christian Identity Using Collective Memory And Critical Contextualization, Kris Stewart Kappler

ATS Dissertations

No abstract provided.

Spectatorial Shock And Carnal Consumption: (Re)Envisaging Historical Trauma In New French Extremity, Christopher Butler

USF Tampa Graduate Theses and Dissertations

New French Extremity films are violent, transgressive, and break many social taboos in their narratives. However, this genre's directors are intelligent and construct these films with clues to France's past and how it still has implications in the present. This thesis was written to point out how New French Extremity films offer spectators the potential to reincorporate traumatic moments in French history by juxtaposing them against present day social, political, and economic ideologies. The purpose for this course of study was to investigate historical encounters that are present in New French Extremity filmmaking, something that has yet to be addressed …

Home Sweet Home: An Infinite Grid Of Memory And Repressed Abuse Trauma, Melissa Bush

Electronic Theses and Dissertations

Incorporating traditional craft mediums of crochet and embroidery, I use digital technology to experiment with wording to graphically represent my abuse trauma. Due to the severity of the subject matter and the work ethic I employ in my art practice, using my hands and being completely involved is a form of masochistic pleasure. My process takes on a Sisyphean approach of penance for the sins of others in my work. During my studio practice, my process reaches a meditative state where my mind is clear and free of the burden. Once I've completed a panel of trauma, the burden is …

Googling To Forget: The Cognitive Processing Of Internet Search, Elizabeth T. Friede

CMC Senior Theses

Technology is currently extremely integrated with everyday life. Popular media has made bold claims that the internet is making us “dumber” and people struggle to remember information more now than they ever have in the past. Scientific research on the effect of internet search on cognition and memory is still in its infancy. This research will analyze the literature and theories discussing memory and the internet. Based on an original experiment by Sparrow, Liu, and Wegner. 20 participants (10 young adults and 10 older adults) performed a typing task with twenty trivia statements, followed by a recall and recognition memory …

Variability Across Repeat Assessment Of Working Memory And Processing Speed In Referred Populations, Dawn Baker

Theses and Dissertations

Developmentally, it is expected that the processes of working memory and processing speed will improve throughout childhood as a child's brain develops. However, students with learning, attention, and other childhood disorders often display difficulties in these areas. This study investigated the use of repeated measures to ascertain variability over time of two important cognitive processes: Working Memory and Processing Speed in a clinically referred population as measured by the WISC-IV to determine if a significant discrepancy exists between administrations. The study also investigated whether differences in Working Memory and Processing Speed from administration to administration would be greater in children …

Una Cárcel De Cultura: Secuelas De La Dictadura Chilena En Un Centro De Arte Comunitario, Sofia Leblanc

Honors Papers

In Chile, wounds from the Pinochet dictatorship of 1973 to 1990 still fester under the surface of its post-transitional society. The regime of terror lives on in economic policies, architecture, the country's grave-pocked landscape, and in the everyday lives of Chileans. My research examines a former prison and torture center that has been converted into a cultural park: a space of culture, art, and community, sanctioned and administered by the state. It serves as a microcosm for Chile, which has chosen to erase its violent past while also perpetuating a system of class stratification and power structures that come directly …

Hypnosis, Hypnotizability, Memory And Involvement In Films, Reed Maxwell

Graduate Dissertations and Theses

Researchers have reported increased involvement in reading (Baum and Lynn, 1981) and music-listening (Snodgrass and Lynn, 1989) tasks during hypnosis. We predicted a similar effect for film viewing of greater absorption and involvement in an emotional (The Champ) versus a non-emotional ( Scenes of Toronto) film clip. We also examined the effects of hypnosis and film valence on memory and state depersonalization. Our study is the first to use state dissociation to index response to hypnosis. We tested 121 participants who completed measures of absorption and trait dissociation and the Harvard Group Scale of Hypnotic Susceptibility and …

Memory Of A Racist Past — Yazoo: Integration In A Deep-Southern Town By Willie Morris, Nick J. Sciullo

Nick J. Sciullo

Willie Morris was in many ways larger than life. Born in Jackson, Mississippi, he moved with his family to Yazoo City, Mississippi at the age of six months. He attended and graduated from the University of Texas at Austin where his scathing editorials against racism in the South earned him the hatred of university officials. After graduation, he attended Oxford University on a Rhodes scholarship. He would join Harper’s Magazine in 1963, rising to become the youngest editor-in-chief in the magazine’s history. He remained at this post until 1971 when he resigned amid dropping ad sales and a lack of …