Digital Commons Network^™

It's A Blessing, Douglas E. Abrams

Faculty Publications

No abstract provided.

Global Distribution Of Atmospheric Phosphorus Sources, Concentrations And Deposition Rates, And Anthropogenic Impacts, Natalie Mahowald, Timothy D. Jickells, Alex R. Baker, Paulo Artaxo, Claudia R. Benitez-Nelson, Gilles Bergametti, Tami C. Bond, Ying Chen, David D. Cohen, Barak Herut, Nilgun Kubilay, Remi Losno, Chao Luo, Willy Maenhaut, Kenneth A. Mcgee, Gregory S. Okin, Ronald L. Siefert, Seigen Tsukuda

Faculty Publications

[1] A worldwide compilation of atmospheric total phosphorus (TP) and phosphate (PO4) concentration and deposition flux observations are combined with transport model simulations to derive the global distribution of concentrations and deposition fluxes of TP and PO4. Our results suggest that mineral aerosols are the dominant source of TP on a global scale (82%), with primary biogenic particles (12%) and combustion sources (5%) important in nondusty regions. Globally averaged anthropogenic inputs are estimated to be ∼5 and 15% for TP and PO4, respectively, and may contribute as much as 50% to the deposition over the oligotrophic ocean where productivity may …

Topographic Effects On The Path And Evolution Of Loop Current Eddies, Kyung Hoon Hyun, Patrick J. Hogan

Faculty Publications

Eddy-topography (ET) interactions are important in determining the path and evolution of oceanic eddies, including Loop Current Eddies (LCE) in the Gulf of Mexico (GOM). We use the Hybrid Coordinate Ocean Model and satellite altimetry data to investigate the ET interactions and the impact on LCE pathway evolution in the GOM. Satellite altimetry reveals that LCEs translate dominantly westward in the central GOM and strongly collide and reflect against topography near the continental slope in the northern and western GOM. The result is the frequent generation of an anticyclone-cyclone (AC) pair in conjunction with the LCEs. In the absence of …

Chromosomal Inversions Between Human And Chimpanzee Lineages Caused By Retrotransposons, Jungnam Lee, Kyudong Han, Thomas J. Meyer, Heui Soo Kim, Mark A. Batzer

Faculty Publications

The long interspersed element-1 (LINE-1 or L1) and Alu elements are the most abundant mobile elements comprising 21% and 11% of the human genome, respectively. Since the divergence of human and chimpanzee lineages, these elements have vigorously created chromosomal rearrangements causing genomic difference between humans and chimpanzees by either increasing or decreasing the size of genome. Here, we report an exotic mechanism, retrotransposon recombination-mediated inversion (RRMI), that usually does not alter the amount of genomic material present. Through the comparison of the human and chimpanzee draft genome sequences, we identified 252 inversions whose respective inversion junctions can clearly be characterized. …

Structure Of A Complete Integrin Ectodomain In A Physiologic Resting State And Activation And Deactivation By Applied Forces, Jianghai Zhu, Bing Hao Luo, Tsan Xiao, Chengzhong Zhang, Noritaka Nishida, Timothy A. Springer

Faculty Publications

The complete ectodomain of integrin αIIbβ3 reveals a bent, closed, low-affinity conformation, the β knee, and a mechanism for linking cytoskeleton attachment to high affinity for ligand. Ca and Mg ions in the recognition site, including the synergistic metal ion binding site (SyMBS), are loaded prior to ligand binding. Electrophilicity of the ligand-binding Mg ion is increased in the open conformation. The β3 knee passes between the β3-PSI and αIIb-knob to bury the lower β leg in a cleft, from which it is released for extension. Different integrin molecules in crystals and EM reveal breathing that appears on pathway to …

Design, Synthesis, And Structure - Activity Relationship, Molecular Modeling, And Nmr Studies Of A Series Of Phenyl Alkyl Ketones As Highly Potent And Selective Phosphodiesterase-4 Inhibitors, Shilong Zheng, Gurpreet Kaur, Huanchen Wang, Minyong Li, Megan Macnaughtan, Xiaochuan Yang, Suazette Reid, James Prestegard, Binghe Wang, Hengming Ke

Faculty Publications

Phosphodiesterase 4 catalyzes the hydrolysis of cyclic AMP and is a target for the development of anti-inflammatory agents. We have designed and synthesized a series of phenyl alkyl ketones as PDE4 inhibitors. Among them, 13 compounds were identified as having submicromolar IC50 values. The most potent compounds have IC50 values of in the mid- to low-nanomolar range. Compound 5v also showed preference for PDE4 with selectivity of >2000-fold over PDE7, PDE9, PDE2, and PDE5. Docking of 5v, 5zf, and 5za into the binding pocket of the PDE4 catalytic domain revealed a similar binding profile to PDE4 with rolipram except that …

Parental Hesitation As A Factor In Delayed Childhood Immunization, Karlen E. (Beth) Luthy, Renea L. Beckstrand, Neil E. Peterson

Faculty Publications

Introduction: One reason for lower immunization rates is that some parents hesitate to have their children immunized. A hesitancy questionnaire was developed to identify reasons parents hesitate in having their children immunized.

Methods: The hesitancy questionnaire was distributed from local pediatric and family practice offices and from the area's county health department. To be eligible, participants needed to be present in the clinic with a child needing a minimum of one immunization that was at least 6 months overdue.

Results: When questioned why their child was overdue for immunizations, the most common response was that participants were confused about the …

The Role Of Msa In Staphylococcus Aureus Biofilm Formation, Karthik Sambanthamoorthy, Antony Schwartz, Vijayaraj Nagarajan, Mohamed O. Elasri

Faculty Publications

Background

Staphylococcus aureus is an important pathogen that forms biofilms. The global regulator sarA is essential for biofilm formation. Since the modulator of sarA (msa) is required for full expression of sarA and regulates several virulence factors, we examined the capacity of the msa mutant to form biofilm.

Results

We found that mutation of msa results in reduced expression of sarA in biofilm and that the msa mutant formed a weak and unstable biofilm. The msa mutant is able to adhere to surfaces and begins to form biofilm but fails to mature indicating that the defect of the …

Measurement Of The Single-Top-Quark Production Cross Section At Cdf, T. Aaltonen, J. Adelman, T. Akimoto, M. G. Albrow, B. Álvarez González, S. Amerio, D. Amidei, A. Anastassov, A. Annovi, J. Antos, G. Apollinari, A. Apresyan, T. Arisawa, A. Artikov, W. Ashmanskas, A. Attal, A. Aurisano, F. Azfar, P. Azzurri, W. Badgett, A. Barbaro-Galtieri, V. E. Barnes, B. A. Barnett, V. Bartsch, G. Bauer, P. H. Beauchemin, F. Bedeschi, P. Bednar

Faculty Publications

We report a measurement of the single-top-quark production cross section in 2.2fb-1 of pp̄ collision data collected by the Collider Detector at Fermilab at s=1.96TeV. Candidate events are classified as signal-like by three parallel analyses which use likelihood, matrix element, and neural network discriminants. These results are combined in order to improve the sensitivity. We observe a signal consistent with the standard model prediction, but inconsistent with the background-only model by 3.7 standard deviations with a median expected sensitivity of 4.9 standard deviations. We measure a cross section of 2.2-0.6+0.7(stat+syst)pb, extract the Cabibbo-Kobayashi-Maskawa matrix-element value |Vtb|=0.88-0.12+0.13(stat+syst)±0.07(theory), and set the limit …

Search For The Higgs Boson Produced In Association With Z→ℓ+ℓ- In Pp̄ Collisions At S=1.96tev, T. Aaltonen, J. Adelman, T. Akimoto, M. G. Albrow, B. Álvarez González, S. Amerio, D. Amidei, A. Anastassov, A. Annovi, J. Antos, G. Apollinari, A. Apresyan, T. Arisawa, A. Artikov, W. Ashmanskas, A. Attal, A. Aurisano, F. Azfar, P. Azzurri, W. Badgett, A. Barbaro-Galtieri, V. E. Barnes, B. A. Barnett, V. Bartsch, G. Bauer, P. H. Beauchemin, F. Bedeschi, P. Bednar

Faculty Publications

We present a search for the Higgs boson in the process qq̄→ ZH→ℓ+ℓ-bb̄. The analysis uses an integrated luminosity of 1fb-1 of pp̄ collisions produced at s=1.96TeV and accumulated by the upgraded Collider Detector at Fermilab (CDF II). We employ artificial neural networks both to correct jets mismeasured in the calorimeter and to distinguish the signal kinematic distributions from those of the background. We see no evidence for Higgs boson production, and set 95% C.L. upper limits on σZHB(H→bb̄), ranging from 1.5 to 1.2 pb for a Higgs boson mass (mH) of 110 to 150GeV/c2. © 2008 The American Physical …

Search For Supersymmetry In Pp Collisions At S=1.96tev Using The Trilepton Signature For Chargino-Neutralino Production, T. Aaltonen, J. Adelman, T. Akimoto, M. G. Albrow, B. Álvarez González, S. Amerio, D. Amidei, A. Anastassov, A. Annovi, J. Antos, G. Apollinari, A. Apresyan, T. Arisawa, A. Artikov, W. Ashmanskas, A. Attal, A. Aurisano, F. Azfar, P. Azzurri, W. Badgett, A. Barbaro-Galtieri, V. E. Barnes, B. A. Barnett, V. Bartsch, G. Bauer, P. H. Beauchemin, F. Bedeschi, P. Bednar

Faculty Publications

We use the three lepton and missing energy trilepton signature to search for chargino-neutralino production with 2.0fb-1 of integrated luminosity collected by the CDF II experiment at the Tevatron pp collider. We expect an excess of approximately 11 supersymmetric events for a choice of parameters of the mSUGRA model, but our observation of 7 events is consistent with the standard model expectation of 6.4 events. We constrain the mSUGRA model of supersymmetry and rule out chargino masses up to 145GeV/c2 for a specific choice of parameters. © 2008 The American Physical Society.

Effect Of Linker Structure On Surface Density Of Aptamer Monolayers And Their Corresponding Protein Binding Efficiency, Subramanian Balamurugan, Anne Obubuafo, Robin L. Mccarley, Steven A. Soper, David A. Spivak

Faculty Publications

A systematic study is reported on the effect of linker size and its chemical composition toward ligand binding to a surface-immobilized aptamer, measured using surface plasmon resonance. The results, using thrombin as the model system, showed that as the number of thymidine (T) units in the linker increases from 0 to 20 in four separate increments (T0, T 5, T10, T20), the surface density of the aptamer decreased linearly from approximately 25 to 12 pmol·cm -2. The decrease in aptamer surface density occurred due to the increased size of the linker molecules. In addition, thrombin binding capacity was shown to …

Decision Tree Ensemble: Small Heterogeneous Is Better Than Large Homogeneous, Mike Gashler, Christophe G. Giraud-Carrier, Tony R. Martinez

Faculty Publications

Using decision trees that split on randomly selected attributes is one way to increase the diversity within an ensemble of decision trees. Another approach increases diversity by combining multiple tree algorithms. The random forest approach has become popular because it is simple and yields good results with common datasets. We present a technique that combines heterogeneous tree algorithms and contrast it with homogeneous forest algorithms. Our results indicate that random forests do poorly when faced with irrelevant attributes, while our heterogeneous technique handles them robustly. Further, we show that large ensembles of random trees are more susceptible to diminishing returns …

Learning-Based Fusion For Data Deduplication, Sabra Dinerstein, Parris K. Egbert, Stephen W. Clyde, Jared Dinerstein

Faculty Publications

Rule-based deduplication utilizes expert domain knowledge to identify and remove duplicate data records. Achieving high accuracy in a rule-based system requires the creation of rules containing a good combination of discriminatory clues. Unfortunately, accurate rule-based deduplication often requires significant manual tuning of both the rules and the corresponding thresholds. This need for manual tuning reduces the efficacy of rule-based deduplication and its applicability to real-world data sets. No adequate solution exists for this problem. We propose a novel technique for rule-based deduplication. We apply individual deduplication rules, and combine the resultant match scores via learning-based information fusion. We show empirically …

Estimating Tmr Reliability On Fpgas Using Markov Models, Daniel Mcmurtrey, Keith S. Morgan, Brian Pratt, Michael J. Wirthlin

Faculty Publications

This paper summarizes several reliability models for modeling FPGA reliability using Markov models.

Two Evolutionarily Conserved Sequence Elements For Peg3/Usp29 Transcription, Jeong Do Kim, Sungryul Yu, Jung Ha Choo, Joomyeong Kim

Faculty Publications

Background: Two evolutionarily Conserved Sequence Elements, CSE1 and CSE2 (YY1 binding sites), are found within the 3.8-kb CpG island surrounding the bidirectional promoter of two imprinted genes, Peg3 (Paternally expressed gene 3) and Usp29 (Ubiquitin-specific protease 29). This CpG island is a likely ICR (Imprinting Control Region) that controls transcription of the 500-kb genomic region of the Peg3 imprinted domain. Results: The current study investigated the functional roles of CSE1 and CSE2 in the transcriptional control of the two genes, Peg3 and Usp29, using cell line-based promoter assays. The mutation of 6 YY1 binding sites (CSE2) reduced the transcriptional activity …

L1 Recombination-Associated Deletions Generate Human Genomic Variation, Kyudong Han, Jungnam Lee, Thomas J. Meyer, Paul Remedios, Lindsey Goodwin, Mark A. Batzer

Faculty Publications

Mobile elements have created structural variation in the human genome through their de novo insertions and post-insertional genomic rearrangements. L1 elements are a type of long interspersed element (LINE) that is dispersed at high copy numbers within most mammalian genomes. To determine the magnitude of L1 recombination-associated deletions (L1RADs), we computationally extracted L1RAD candidates by comparing the human and chimpanzee genomes and verified each of the L1RAD events by using wet-bench analyses. Through these analyses, we identified 73 human-specific L1RAD events that occurred subsequent to the divergence of the human and chimpanzee lineages. Despite their low frequency, the L1RAD events …

Nowhere To Hide: Finding Plagiarized Documents Based On Sentence Similarity, Nathaniel Gustafson, Yiu-Kai D. Ng, Maria Soledad Pera

Faculty Publications

Plagiarism is a serious problem that infringes copyrighted documents/materials, which is an unethical practice and decreases the economic incentive received by authors (owners) of the original copies. Unfortunately, plagiarism is getting worse due to the increasing number of online publications on the Web, which facilitates locating and paraphrasing information. In solving this problem, we propose a novel plagiarism-detection method, called SimPaD, which (i) establishes the degree of resemblance between any two documents D1 and D2 based on their sentence-to-sentence similarity computed by using pre-defined word-correlation factors, and (ii) generates a graphical view of sentences that are similar (or the same) …

The Gendered Meanings Of Assets For Divorce, Jeffrey P. Dew

Faculty Publications

Scholars identified a negative relationship between assets and divorce decades ago, but the mechanisms behind this relationship remain unknown. Using data from the National Survey of Families and Households (N = 4,721 couples), this study compared three mechanisms that might link assets and divorce. Non-proportional Cox hazard models indicated that two of the three mechanisms explained the relationship between assets and divorce. Wives’ marital satisfaction and their perceptions of their hypothetical post-divorce standard of living completely mediated the relationship between assets and divorce. The relationship between assets and divorce was not related to husbands’ characteristics.

Low Energy Gamma-Ray Emission From Galactic Black Holes, Gary L. Case, Michael L. Cherry, James C. Ling, William A. Wheaton

Faculty Publications

X-ray observations of Galactic black holes (GBHs) such as Cygnus X-1 have greatly advanced the understanding of these objects. However, the vast majority of the observations have been restricted to energies below ∼ 200 keV. The Compton Gamma-Ray Observatory (CGRO) allowed for the first time simultaneous observations at energies from ∼ 25 keV up to > 1 GeV. In particular, the BATSE experiment aboard CGRO was able to monitor low-energy gamma-ray emission from Cygnus X-1, as well as other GBHs, nearly continuously over a nine year period. Using the Enhanced BATSE Occultation Package (EBOP), light curves and spectra in the energy …

Identification Of Adropin As A Secreted Factor Linking Dietary Macronutrient Intake With Energy Homeostasis And Lipid Metabolism, K. Ganesh Kumar, James L. Trevaskis, Daniel D. Lam, Gregory M. Sutton, Robert A. Koza, Vladimir N. Chouljenko, Konstantin G. Kousoulas, Pamela M. Rogers, Robert A. Kesterson, Marie Thearle, Anthony W. Ferrante, Randall L. Mynatt, Thomas P. Burris, Jesse Z. Dong, Heather A. Halem, Michael D. Culler, Lora K. Heisler, Jacqueline M. Stephens, Andrew A. Butler

Faculty Publications

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated. Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis Associated (Enho), expressed in liver and brain. Liver Enho expression is regulated by nutrition: lean C57BL/6J mice fed high-fat diet (HFD) exhibited a rapid increase, while fasting reduced expression compared to controls. However, liver Enho expression declines with diet-induced obesity (DIO) associated with 3 months of HFD or with genetically induced obesity, suggesting an association with metabolic disorders in the obese state. In DIO mice, transgenic overexpression or systemic adropin treatment attenuated hepatosteatosis and …

Identification Of Adropin As A Secreted Factor Linking Dietary Macronutrient Intake With Energy Homeostasis And Lipid Metabolism, K. Ganesh Kumar, James L. Trevaskis, Daniel D. Lam, Gregory M. Sutton, Robert A. Koza, Vladimir N. Chouljenko, Konstantin G. Kousoulas, Pamela M. Rogers, Robert A. Kesterson, Marie Thearle, Anthony W. Ferrante, Randall L. Mynatt, Thomas P. Burris, Jesse Z. Dong, Heather A. Halem, Michael D. Culler, Lora K. Heisler, Jacqueline M. Stephens, Andrew A. Butler

Faculty Publications

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated. Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis Associated (Enho), expressed in liver and brain. Liver Enho expression is regulated by nutrition: lean C57BL/6J mice fed high-fat diet (HFD) exhibited a rapid increase, while fasting reduced expression compared to controls. However, liver Enho expression declines with diet-induced obesity (DIO) associated with 3 months of HFD or with genetically induced obesity, suggesting an association with metabolic disorders in the obese state. In DIO mice, transgenic overexpression or systemic adropin treatment attenuated hepatosteatosis and …

Teaching The Teacher Program To Assist Nurse Managers To Educate Nursing Staff In Ecuadorian Hospitals, Sheri P. Palmer, Sondra Heaston

Faculty Publications

Continuing education for hospital staff nurses is a concern worldwide. Current research shows that continuing education among nurses can positively affect patient outcomes (O’Brien, T., Freemantle, N., Oxman, A, et al., 2002. Interactive continuing education workshops or conferences can improve professional practice and patient outcomes. Journal of Evidence Based Nursing. 26 (5)). Seeing a need for improved patient outcomes among hospitals in Ecuador, we conducted a teaching the teacher program to assist nurse managers to carry-out continuing education in their hospital system. This teaching the teacher program was established through the collaboration between one College of Nursing in Utah, USA …

Fingering Instabilities On Reaction Fronts In The Co Oxidation Reaction On Pt(100), D. Bilbao, Jochen A. Lauterbach

Faculty Publications

Fingering instabilities arising from local perturbations to planar reaction fronts in the CO oxidation reaction on Pt(100) are presented. CO oxidation represents a heterogeneous nonlinear system with the necessary kinetic and diffusive transport properties to support the development of fingered wave fronts. External forcing was utilized to create CO wave fronts on an otherwise monostable, O-covered surface, which, upon destabilization, gave rise to fingers of adsorbed CO extending into the O adlayer ahead of the reaction front. Finger spreading and tip-splitting were observed as the finger pattern evolved towards an intrinsic wavelength, independent of the length of the reaction front, …

Circumventing Congress: How The Federal Courts Opened The Door To Impeaching Criminal Defendants With Prior Convictions, Jeffrey Bellin

Faculty Publications

This Article spotlights the flawed analytical framework at the heart of the federal courts’ approach to one of the most controversial trial practices in American criminal jurisprudence — the admission of prior convictions to impeach the credibility of defendants who testify. As the Article explains, the flawed approach is a byproduct of the courts’ reliance on a five-factor analytical framework to implement the governing legal standard enacted by Congress in Federal Rule of Evidence 609. Tracing the evolution of the fivefactor framework from its roots in pre-Rule 609 case law, the Article demonstrates that the courts’ reinterpretation of the framework …

Search For Charged Current Coherent Pion Production On Carbon In A Few-Gev Neutrino Beam, K. Hiraide, J. L. Alcaraz-Aunion, S. J. Brice, L. Bugel, J. Catala-Perez, G. Cheng, J. M. Conrad, Z. Djurcic, U. Dore, D. A. Finley, A. J. Franke, C. Giganti, J. J. Gomez-Cadenas, P. Guzowski, A. Hanson, Y. Hayato, G. Jover-Manas, G. Karagiorgi, T. Katori, Y. K. Kobayashi, T. Kobilarcik, H. Kubo, Y. Kurimoto, W. C. Louis, P. F. Loverre, L. Ludovici, K. B.M. Mahn, C. Mariani, S. Masuike, K. Matsuoka, W. Metcalf, G. Mills, G. Mitsuka

Faculty Publications

The SciBooNE Collaboration has performed a search for charged current coherent pion production from muon neutrinos scattering on carbon, νμC12→μ-C12π+, with two distinct data samples. No evidence for coherent pion production is observed. We set 90% confidence level upper limits on the cross section ratio of charged current coherent pion production to the total charged current cross section at 0.67×10-2 at mean neutrino energy 1.1 GeV and 1.36×10-2 at mean neutrino energy 2.2 GeV. © 2008 The American Physical Society.

First Measurement Of The Fraction Of Top-Quark Pair Production Through Gluon-Gluon Fusion, T. Aaltonen, J. Adelman, T. Akimoto, M. G. Albrow, B. Álvarez González, S. Amerio, D. Amidei, A. Anastassov, A. Annovi, J. Antos, M. Aoki, G. Apollinari, A. Apresyan, T. Arisawa, A. Artikov, W. Ashmanskas, A. Attal, A. Aurisano, F. Azfar, P. Azzi-Bacchetta, P. Azzurri, N. Bacchetta, W. Badgett, A. Barbaro-Galtieri, V. E. Barnes, B. A. Barnett, S. Baroiant, V. Bartsch

Faculty Publications

We present the first measurement of σ(gg→tt̄)/ σ(pp̄→tt̄). We use 0.96fb-1 of s=1.96TeV pp̄ collision data recorded with the CDF II detector at Fermilab. Using charged particles with low transverse momentum in tt̄ events, we find σ(gg→ tt̄)/σ(pp̄→tt̄)=0.07±0.14(stat)±0. 07(syst), corresponding to a 95% confidence level upper limit of 0.33, in agreement with the standard model next-to-leading-order prediction of 0.15±0.05. © 2008 The American Physical Society.

Dispelling Grammar Myths: 'To Split' Or 'Not To Split' The Infinitive, Rebecca K. Blemberg

Faculty Publications

No abstract provided.

Prompt Optical Observations Of Grb 080330 And Grb 080413a, F. Yuan, E. S. Rykoff, B. E. Schaefer, W. Rujopakarn, T. Güver, F. Aharonian, C. W. Akerlof, M. C.B. Ashley, S. D. Barthelmy, N. Gehrels, E. Gögüş, D. Horns, Ü Kiziloǧlu, H. A. Krimm, T. A. Mckay, M. Özel, A. Phillips, R. M. Quimby, G. Rowell, H. F. Swan, W. T. Vestrand, J. C. Wheeler, J. Wren

Faculty Publications

We report on the results of rapid responses to GRB 080330 and GRB 080413A by the ROTSE-IIIb and ROTSE-IIIc telecopes. In both cases, optical follow-up started during the prompt emission phase and recorded optical flares peaking at similar times as the last hard X-ray pulses detected by the Swift BAT. For both events, the XRT observations started at the end of the prompt BAT detection and displayed an evolution in time opposite to the optical lightcurve. These very early observations provide us an opportunity to probe the onset of afterglow for these two events. © 2008 American Institute of Physics.

Host-Pathogen Interactions, Insect Outbreaks, And Natural Selection For Disease Resistance, Bret D. Elderd, Jonathan Dushoff, Greg Dwyer

Faculty Publications

The theory of insect population dynamics has shown that heterogeneity in natural-enemy attack rates is strongly stabilizing. We tested the usefulness of this theory for outbreaking insects, many of which are attacked by infectious pathogens. We measured heterogeneity among gypsy moth larvae in their risk of infection with a nucleopolyhedrovirus, which is effectively heterogeneity in the pathogen's attack rate. Our data show that heterogeneity in infection risk in this insect is so high that it leads to a stable equilibrium in the models, which is inconsistent with the outbreaks seen in North American gypsy moth populations. Our data further suggest …