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Characterization Of Hypertension Through Multivariate Analysis Utilizing Linear And Nonlinear Methods, Diane L. Donnelly
Characterization Of Hypertension Through Multivariate Analysis Utilizing Linear And Nonlinear Methods, Diane L. Donnelly
Dissertations
Analysis of blood pressure by nonlinear methods is vastly underutilized in current research. As such, 24-hour ambulatory blood pressure data from a small cohort of borderline hypertensive and normotensive subjects were analyzed using linear and nonlinear methods. Data were collected and provided by researchers from Columbia University. The cohort size was twelve subjects, consisting of two groups of six each. Although disease state was known, group membership for individual subjects was not. Therefore, one aspect of this research was to separate the cohort, a-priori, into two distinct, evenly sized groups, based solely on analysis results. Separation was accomplished by the …
Lung Circulation Modeling: Status And Prospect, Anne V. Clough, Said H. Audi, Robert C. Molthen, Gary S. Krenz
Lung Circulation Modeling: Status And Prospect, Anne V. Clough, Said H. Audi, Robert C. Molthen, Gary S. Krenz
Biomedical Engineering Faculty Research and Publications
Mathematical modeling has been used to interpret anatomical and physiological data obtained from metabolic and hemodynamic studies aimed at investigating structure-function relationships in the vasculature of the lung, and how these relationships are affected by lung injury and disease. The indicator dilution method was used to study the activity of redox processes within the lung. A steady-state model of the data was constructed and used to show that pulmonary endothelial cells may play an important role in reducing redox active compounds and that those reduction rates can be altered with oxidative stress induced by exposure to high oxygen environments. In …