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Investigating The Persistence And "Naturalization" Potential Of Salmonella In Non-Host Environments Using Culture-Based And Molecular-Based Fingerprinting Techniques, Robyn L. Morrison
Investigating The Persistence And "Naturalization" Potential Of Salmonella In Non-Host Environments Using Culture-Based And Molecular-Based Fingerprinting Techniques, Robyn L. Morrison
Theses and Dissertations (Comprehensive)
Recent studies suggest the potential exists for enteric microorganisms to become “naturalized” to the complex natural environment through maintenance of their populations via replication and adaptation to the stress imposed by their external surroundings. The aim of this research was to better understand the potential for antimicrobial resistant (AMR) Salmonella to become “naturalized” and the physiological adaptations that allow for non-host survivability as reflected by AMR and community profiling. To better elucidate the prominent factors leading to a “naturalized” condition, two approaches were taken: 1) survey-based field research to gain perspective on the prevalence of AMR Salmonella isolated from variously …
Isolation And Characterization Of Natural Antimicrobials From Plant And Marine Organisms, Corene Barbara Canning
Isolation And Characterization Of Natural Antimicrobials From Plant And Marine Organisms, Corene Barbara Canning
Wayne State University Dissertations
Antibiotic agents have been found to have a limited lifespan due to the ability of microrganisms to develop antimicrobial resistance. In this study a number extracts of plant and marine organisms were evaluated for their antimicrobial activity against a number of high priority pathogens. Bioassay-guided fractionation of four extracts led to the identification of compounds with inhibitory activity; including one previously unknown compound. Compounds were evaluated through a variety of techniques including broth microdilution assay to determine each compound's MIC and MBC. The majority of the compounds showed antimicrobial activity equal to, if not better than, the commonly used antimicrobial …