Digital Commons Network^™

Evolution Of Clinical Trials Throughout History, Emma M. Nellhaus, Todd H. Davies

Todd H. Davies

The history of clinical research accounts for the high ethical, scientific, and regulatory standards represented in current practice. In this review, we aim to describe the advances that grew from failures and provide a comprehensive view of how the current gold standard of clinical practice was born. This discussion of the evolution of clinical trials considers the length of time and efforts that were made in order to designate the primary objective, which is providing better care for our patients. A gradual, historic progression of scientific methods such as comparison of interventions, randomization, blinding, and placebos in clinical trials demonstrates …

Preventing And Treating Narcotic Addiction — A Century Of Federal Drug Control, David Courtwright

David T. Courtwright

Segregation Of A Latent High Adiposity Phenotype In Families With A History Of Type 2 Diabetes Mellitus Implicates Rare Obesity-Susceptibility Genetic Variants With Large Effects In Diabetes-Related Obesity, Arthur B. Jenkins, Marijka Batterham, Dorit Samocha-Bonet, Katherine Tonks, Jerry R. Greenfield, Lesley V. Campbell

Dr Marijka Batterham

Background We recently reported significantly greater weight gain in non-diabetic healthy subjects with a 1st degree family history (FH+) of type 2 diabetes mellitus (T2DM) than in a matched control group without such history (FH−) during voluntary overfeeding, implying co-inheritance of susceptibilities to T2DM and obesity. We have estimated the extent and mode of inheritance of susceptibility to increased adiposity in FH+. Methods Normoglycaemic participants were categorised either FH+ (≥1 1st degree relative with T2DM, 50F/30M, age 45±14 (SD) yr) or FH− (71F/51M, age 43±14 yr). Log-transformed anthropometric measurements (height, hip and waist circumferences) and lean, bone and fat mass …

Using Cultural Immersion As The Platform For Teaching Aboriginal And Torres Strait Islander Health In An Undergraduate Medical Curriculum, Janie Smith, Christina L. Wolfe, Shannon Springer, Mary Martin, John Togno, Katrina A. Bramstedt, Sally Sargeant, Brad Murphy

Janie Smith

In 2011 Bond University was looking for innovative ways to meet the professional standards and guidelines in Aboriginal and Torres Strait Islander health into its Bachelor of Medicine, Bachelor of Surgery (MBBS) curriculum. In 2012 Bond piloted a compulsory cultural immersion program for all first year students, which is now a usual part of the MBBS program. Methodology The methodology included three phases: establishing an Indigenous health group; determining the Aboriginal and Torres Strait Islander educational content based on the professional standards; and developing nine educational sessions and resources; as well as significant administrative processes. The cultural immersion was piloted …

Using Cultural Immersion As The Platform For Teaching Aboriginal And Torres Strait Islander Health In An Undergraduate Medical Curriculum, Janie Smith, Christina L. Wolfe, Shannon Springer, Mary Martin, John Togno, Katrina A. Bramstedt, Sally Sargeant, Brad Murphy

Katrina A. Bramstedt

In 2011 Bond University was looking for innovative ways to meet the professional standards and guidelines in Aboriginal and Torres Strait Islander health into its Bachelor of Medicine, Bachelor of Surgery (MBBS) curriculum. In 2012 Bond piloted a compulsory cultural immersion program for all first year students, which is now a usual part of the MBBS program. Methodology The methodology included three phases: establishing an Indigenous health group; determining the Aboriginal and Torres Strait Islander educational content based on the professional standards; and developing nine educational sessions and resources; as well as significant administrative processes. The cultural immersion was piloted …

Using Cultural Immersion As The Platform For Teaching Aboriginal And Torres Strait Islander Health In An Undergraduate Medical Curriculum, Janie Smith, Christina L. Wolfe, Shannon Springer, Mary Martin, John Togno, Katrina A. Bramstedt, Sally Sargeant, Brad Murphy

Sally Sargeant

In 2011 Bond University was looking for innovative ways to meet the professional standards and guidelines in Aboriginal and Torres Strait Islander health into its Bachelor of Medicine, Bachelor of Surgery (MBBS) curriculum. In 2012 Bond piloted a compulsory cultural immersion program for all first year students, which is now a usual part of the MBBS program. Methodology The methodology included three phases: establishing an Indigenous health group; determining the Aboriginal and Torres Strait Islander educational content based on the professional standards; and developing nine educational sessions and resources; as well as significant administrative processes. The cultural immersion was piloted …

High-Throughput Sequencing Of Plasma Microrna In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Kevin Ashton, Jana Batovska, Don Staines, Sonja Marshall-Gradisnik

Kevin Ashton

Background: MicroRNAs (miRNAs) are known to regulate many biological processes and their dysregulation has been associated with a variety of diseases including Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). The recent discovery of stable and reproducible miRNA in plasma has raised the possibility that circulating miRNAs may serve as novel diagnostic markers. The objective of this study was to determine the role of plasma miRNA in CFS/ME. Results: Using Illumina high-throughput sequencing we identified 19 miRNAs that were differentially expressed in the plasma of CFS/ME patients in comparison to non-fatigued controls. Following RT-qPCR analysis, we were able to confirm the significant up-regulation …

Splenic Infarction: An Update On William Osler's Observations., Yaacov R Lawrence, Ma Mbbs Mrcp, Russell Pokroy, Mb Bch, Daniel Berlowitz, Mb Bch, Dvora Aharoni, Md, Daniel Hain, Md, Gabriel S Breuer, Md

Yaacov R. Lawrence

BACKGROUND: Osler taught that splenic infarction presents with left upper abdominal quadrant pain, tenderness and swelling accompanied by a peritoneal friction rub. Splenic infarction is classically associated with bacterial endocarditis and sickle cell disease. OBJECTIVES: To describe the contemporary experience of splenic infarction. METHODS: We conducted a chart review of inpatients diagnosed with splenic infarction in a Jerusalem hospital between 1990 and 2003. RESULTS: We identified 26 cases with a mean age of 52 years. Common causes were hematologic malignancy (six cases) and intracardiac thrombus (five cases). Only three cases were associated with bacterial endocarditis. In 21 cases the splenic …

Endurance Training History Influences Individual Responsiveness To Resistance Training, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton, Nigel Taylor

Darryl J McAndrew

No abstract provided.

European Society For The History Of The Human Sciences (Eshhs), Conference 2014, Oulu (Finland), Paper: “Dangerous Passions. The Construction And Cultural And Social Impact Of The ‘Psychiatric’ Framework Of The Passions In France (1790-1830)”, July 22-25 (23th), 2014., Marco Solinas

Marco Solinas

Numerous excellent works have been written on the formation process of ‘psychiatry’ and its concomitant impact on society and culture at the end of the eighteenth century and in the first three decades of the nineteenth century, in particular with regard to France. From Gladys Swain to Dora Weiner, from Jacques Postel to Jan Goldstein, from Jackie Pigeaud to Juan Rigoli, the issue has been analysed in depth and from a variety of different perspectives. However, despite constantly and inevitably resurfacing in these studies, no particular attention has been paid to the passions and emotions drawn up by nascent psychiatry. …

Flood Country: An Environmental History Of The Murray-Darling Basin, Emily O'Gorman

Emily O'Gorman

Floods in the Murray-Darling Basin are crucial sources of water for people, animals and plants in this often dry region of inland eastern Australia. Even so, floods have often been experienced as natural disasters, which have led to major engineering schemes. Flood Country explores the contested and complex history of this region, examining the different ways in which floods have been understood and managed and some of the long-term consequences for people, rivers and ecologies. The book examines many tensions, ranging from early exchanges between Aboriginal people and settlers about the dangers of floods, through to long running disputes between …

Human History Written In Stone And Blood, Zenobia Jacobs, Richard Roberts

Richard G Roberts

Even by archaeological standards, Blombos Cave is a modestly sized shelter. Yet artifacts recovered from just 13 cubic meters of deposit inside transformed our understanding of when our species developed behavioral attributes we associate with “modern” humans. From this cramped hole in a sandstone cliff on the Southern Cape coast of South Africa, Christopher Henshilwood and his colleagues unearthed evidence of symbolic expression, in the form of abstract designs (carved ochre bars) and personal ornaments (shell beads) at least 70,000 years old. That is more than 35,000 years before anything comparable emerged in Europe.

Relative Bias In Diet History Measurements: A Quality Control Technique For Dietary Intervention Trials, Gina S. Martin, Linda C. Tapsell, Marijka Batterham, Kenneth G. Russell

Dr Marijka Batterham

Objective: Investigation of relative bias in diet history measurement during dietary intervention trials. Design: Retrospective analysis of human dietary data from two randomised controlled trials examining modified fat diets in the prevention and treatment of type II diabetes mellitus. Setting: Wollongong, Australia. Subjects: Thirty-five overweight, otherwise healthy subjects in trial 1 and 56 subjects with diabetes in trial 2. Interventions: Diet history interviews and three-day weighed food records administered at one-month intervals in trial 1 and three-month intervals in trial 2. Results: In a cross-sectional bias analysis, graphs of the association between bias and mean dietary intake showed that bias …

The University Of Massachusetts Medical School, A History: Integrating Primary Care And Biomedical Research, Ellen S. More

Ellen S. More

The University of Massachusetts Medical School was chartered in 1962 and opened in 1970, one of the cohort of medical schools founded in response to fears of a physician shortage. In Massachusetts, this translated into a call for more opportunities for the state’s students to attend an affordable school where, it was hoped, they would deliver primary care to the people of their home state. Yet, the original dean and faculty, most of whom were recruited from Boston medical schools, were equally devoted to basic research and tertiary care medicine. This book tells the story of the school’s successful efforts …

Academic Freedom: Protecting "Liberal Science" In Nursing In The 21st Century, S. Kneipp, M. Canales, N. Fahrenwald, Janette Taylor

Janette Y. Taylor

Generating new knowledge through science is one of the most valued contributions of American universities, and is wholly dependent on the tenets of academic freedom. This article provides an overview of academic freedom in the United States, lack of attentiveness to academic freedom in the discipline of nursing, and its relevance for advancing nursing science. Three issues are critically evaluated as they relate to "the free search for truth" that is imperative for scientific progress to occur, including (a) its importance in a liberal science system, (b) recent trends to politically manipulate science, and (c) movements to restrict speech on …

Race And Ethnicity As Variables In Nursing Research, 1952-2000, D. Drevdahl, Janette Taylor, D. Phillips

Janette Y. Taylor

BACKGROUND: Although the use of race and ethnicity as variables in research has increased over the past five decades, there is confusion regarding the meaning of the terms, as well as how the words are defined and determined in scientific inquiry. OBJECTIVE: To review the use of race and ethnicity as variables in nursing research literature. METHODS: Original research articles published in Nursing Research in the years, 1952, 1955, and every 5 years thereafter through 2000 were reviewed. Those articles describing human characteristics (N = 337) were analyzed for content concerning: (a) frequency of racial and ethnic terms, (b) words …

Erythrocyte Biomarker-Based Validation Of A Diet History Method Used In A Dietary Intervention Trial, Craig S. Patch, Karen J Murphy, Jackie Mansour, Linda C. Tapsell, Barbara J. Meyer, Trevor A Mori, Manny Noakes, P Clifton, I Puddey, P Howe

L. C. Tapsell

No abstract provided.

Relative Bias In Diet History Measurements: A Quality Control Technique For Dietary Intervention Trials, Gina S. Martin, Linda C. Tapsell, Marijka Batterham, Kenneth G. Russell

L. C. Tapsell

Objective: Investigation of relative bias in diet history measurement during dietary intervention trials. Design: Retrospective analysis of human dietary data from two randomised controlled trials examining modified fat diets in the prevention and treatment of type II diabetes mellitus. Setting: Wollongong, Australia. Subjects: Thirty-five overweight, otherwise healthy subjects in trial 1 and 56 subjects with diabetes in trial 2. Interventions: Diet history interviews and three-day weighed food records administered at one-month intervals in trial 1 and three-month intervals in trial 2. Results: In a cross-sectional bias analysis, graphs of the association between bias and mean dietary intake showed that bias …

Comparison Of Computerised Dietary Assessments With Diet History And Food Record Data At Baseline In An Australian Food-Based Clinical Trial, Yasmine Probst, Virva Sarmas, Linda C. Tapsell

L. C. Tapsell

Background: Food-based clinical trials are vital to advance the scientific evidence for the impact of food on health. These trials reqUire stringent dietary assessment to substantiate effects. We are evaluating the use of a self-administered computerised dietary assessment (DietAdvice) in a current food based weight loss trial. Objective: This cross sectional study aims to compare data from DietAdvice with diet history (DH) and food record (FR) dietary assessments measured at baseline. Materials and Methods: Baseline data for n=71 overweight (23-60 years, BMI 25-37 kg/m2) participants was utilised. Macronutrient data for matched dietary assessments from n=32 participants was obtained for the …

Endurance Training History Influences Individual Responsiveness To Resistance Training, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton, Nigel Taylor

John Sampson

No abstract provided.

Occupational Safety And Health In The Gambia. Developing Concern For Worker Health, Kennith Culp, M. Bobb, S. Marquez

Kennith R. Culp

It is important for the occupational health nursing community to develop an international interest in worker health in countries with limited resources. The collaboration between The Gambia and the University of Iowa discussed in this article can be replicated in other settings and need not be limited to academic institutions. Corporate sponsorship and inclusion of workplace safety criteria in business contracts provide incentives for fostering change in developing countries.

Rogerian Ethics: An Ethical Inquiry Into Rogers's Life And Science, Howard Butcher

Howard K. Butcher

No abstract provided.

Sacred Disease Of Our Times: Failure Of The Infectious Disease Model Of Spongiform Encephalopathy, Vivian Mcalister

Vivian C. McAlister

BACKGROUND: Public health and agricultural policy attempts to keep bovine spongiform encephalopathy out of North America using infectious disease containment policies. Inconsistencies of the infectious disease model as it applies to the spongiform encephalopathies may result in failure of these policies.

METHODS: Review of historical, political and scientific literature to determine the appropriate disease model of spongiform encephalopathy.

PRINCIPAL FINDINGS: Spongiform encephalopathy has always occurred sporadically in man and other animals. Hippocrates may have described it in goats and cattle. Transmission of spongiform encephalopathy between individuals is too uncommon for it to be usefully considered an infection. Spongiform encephalopathy is …

Functional Infrared Imaging Of The Breast, J. Keyserlingk, P. Ahlgren, E. Yu, N. Belliveau, M. Yassa

Edward Yu

In order to re-assess the potential contribution of infrared (IR) imaging as a first-line component of a multi-imaging strategy using currently available technology, we first review the history of its introduction and clinical application, including the results of the Breast Cancer Detection Demonstration Projects (BCDDP). We then discuss experiments with a new high-resolution, computerized IR station and software program acquired by the Ville Marie Breast Center to assess IR imaging's ability to complement clinical examination and mammography in the early detection of breast cancer. Our goal is to show that high-resolution IR imaging provides additional safe, practical, and objective information …

The Activator Methods Story: Development Of A New Concept In Chiropractic., Dennis M. Richards

Dennis M Richards

This paper documents the development of Activator Methods Chiropractic Technique and the lives of its founders, Drs Warren Lee and Arlan Fuhr.