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Timolol As A Migraine Acute Attack Therapy: Randomized, Otcs Control Study, Shimaa Elgamal, Hossam Egila, Ibrahim Kabbash, Hussien El-Ansarey, Mohamed Elshafie, Osama Elshafei

Mansoura Medical Journal

Background: Migraine is manifested by recurrent headache attacks, with variable characteristics and associated symptoms. Oral beta blockers are widely used to prevent and reduce the frequency these attacks. However, the use of topical beta blockers for acute treatment is still controversial. Aims: In this randomized double – armed study, we aim to compare the efficacy of Timolol 0.5% eyedrops compared to other over-the-counter (OTC) medications used for acute treatment of migraine. Methods: Fifty-seven patients were randomly allocated to group A (treatment group: Timolol 0.5% eyedrops), and group B (control group: OTC drugs including Non-steroidal anti-inflammatory drugs (NSAIDs), caffeine, aspirin, and …

Can Aspirin Be Used As A Prophylactic Treatment In Migraine: A Double Blind Study In Upper Egypt, Mahmoud M. Hasan, Abd Elaziz S. Abd Elaziz, Mohammed A. Mohammed

Al-Azhar International Medical Journal

Background: Migraine is the 2nd most prevalent neurological disease in the world. Women are approximately 3 times more likely than men to have migraine.

Aim To evaluate possible role of aspirin as a prophylactic treatment in patient with migraine

Patients and Methods: In this prospective study sixty seven patients presented by migraine with and without aura. All patients were subjected to both HURT and MIDAS questionnaire before the treatment and .after the first, second and third month of treatment.

Results: Sixty seven participants (31 male and 36 female).Their age ranged from 25-60 years old, divided into 3 groups received placebo, …

Migraine Among Neurology Outpatient Attendants In Mansoura University: Sociodemographic And Migraine Comorbidities Analysis, Mohammad Youssif Ismail Ibrahim, Tamer Mohammad Belal, Hossam Mohammad Egila, Ahmed Gamal Azab

Mansoura Medical Journal

Background: Twelve percent of the population is thought to suffer from migraines. 1% to 2% of individuals worldwide suffer from chronic migraine (CM). Approximately 2.5% of cases who have episodic migraine (EM) develop CM. A number of risk factors are linked to the development of CM. Independent of medication; there is a sizable short-term variance in migraine frequency. Sleep difficulties, psychological illness, and cardiovascular disease are all linked to migraine. It is the second most incapacitating illness globally. Objectives: To evalaute the sociodemographic characteristics of migraineurs and their different co-morbidities. Patients and methods: A cross-sectional study with analytic component was …

A Case-Control Study Of Distinguishing Between Stroke Mimics And True Strokes, Maya Gogtay, Yuvaraj Singh, Neha Varma, Aakriti Soni, Pawina Subedi, David B. Sommer, George M. Abraham, Susan V. George

Journal of Community Hospital Internal Medicine Perspectives

This study was conducted with the primary aim to distinguish patients with a true stroke versus a stroke mimic based on clinical features and imaging. We conducted a retrospective case-control study on 116 adult patients who received alteplase (tPA) to treat acute stroke at our hospital. We further analyzed 79 patients with a normal computed tomography angiography (CTA). Based on their magnetic resonance imaging (MRI) of the brain, they were divided into cases (stroke mimics) and controls (true strokes).

Data were collected retrospectively by reviewing individual medical charts on the electronic medical record (EMR), including age, gender, history of stroke, …

The Use Of Zero Balancing In Vestibular Rehabilitation, Mary L. Behrens

Journal of Transformative Touch

This case study highlights a patient referred for vestibular rehabilitation with vestibular migraine, who was unable to take migraine medication. He was treated with Zero Balancing, a manual therapy technique that balances body structure with energy. After seven treatments his migraines were relieved and he no longer needed therapy.

Effect Of Exercise In Sync With Circadian Preference On Migraine Load In Migraineurs, Elias M. Malek, Graham Mcginnis, James Navalta

International Journal of Exercise Science: Conference Proceedings

Migraines are the most common cause of chronic pain. Effective, non-pharmacological strategies to reduce migraine load are needed. Exercise is an effective strategy, but it is unclear how exercise timing and temporal preference (chronotype)factors modulate the laudatory effects of exercise. Purpose: The purpose of this study was to determine the effects of exercising in-sync or out-of-sync with one’s chronotype on migraine load. Methods: Participants were 7 sedentary individuals who experienced migraines 8+ times per month (age = 34 ± 11 yrs, 167 ± 8 cm, 99 ± 26 kg). Participants were categorized into morning- or evening-types based …

The Efficacy Of A Sumatriptan And Naproxen Combination Pill In A Patient With Chronic Migraines Who Discontinued Triptan Therapy In The Past Due To A Self-Reported Poor Response To Sumatriptan Monotherapy, Ethan M. Cohen

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Mathew NT, Landy S, Stark S, et al. Fixed-dose sumatriptan and naproxen in poor responders to triptans with a short half-life. Headache. 2009;49(7):971-982. https://doi.org/10.1111/j.1526-4610.2009.01458.x

for a patient with chronic migraines who had self-reported poor response to sumatriptan monotherapy.

Migraine Triggers, Adina Jeidel

The Science Journal of the Lander College of Arts and Sciences

Migraines are a painful and life-interrupting disease which strikes around 23 million Americans every year (Goadsby et al., 2017). Not enough studies have been done to help the public fully understand migraines. Details regarding the causes and pathophysiology of migraines continue to be analyzed by physicians and scientists, as no theory has been fully confirmed regarding a migraine’s concrete path. The goal of this scientific review is to provide an overview for the main triggers of migraines, in reference to recent clinical investigations, and to understand why they might cause patients to be more prone to having a migraine attack …

The Effect Of Weather Variables On The Severity, Duration, And Frequency Of Headacheattacks In The Cases Of Episodic Migraine And Episodic Tension-Type Headache, Nergi̇s Akgün, Esra Aciman Demi̇rel, Mustafa Açikgöz, Ulufer Çelebi̇, Fürüzan Köktürk, Hüseyi̇n Tuğrul Atasoy

Turkish Journal of Medical Sciences

Background/aim: Although many headache patients report that the frequency and severity of attacks vary according to the season or weather in clinical practice, the relationship between the characteristics of the attacks and the weather is not very clear in episodic headaches. We aimed to compare the effects of weather variables (temperature, wind speed, wind direction, humidity, pressure, ultraviolet index, and sunshine duration) on episodic migraine (EM) and episodic tension-type headache (ETTH) attacks (incidence, duration, and severity). Materials and methods: Fifty patients with EM and fifty patients with ETTH diagnosed according to International Classification of Headache Disorders-II are included in the …

Cellular Iron Storage And Trafficking Are Affected By Gtn Stimulation In Primary Glial And Meningeal Cell Culture, Lati̇fe Arzu Aral, Mehmet Ali̇ Ergün, Hayrunni̇sa Bolay Belen

Turkish Journal of Biology

A well-balanced intracellular iron trafficking in glial cells plays a role in homeostatic processes. Elevated intracellular iron triggers oxidative stress and cell damage in many neurological disorders, including migraine. This study aimed to investigate the effects of glyceryl trinitrate (GTN), on cellular iron homeostasis, matrixmetalloproteinase (MMP)-9, and calcitonin gene related peptide (CGRP) receptor (CRLR/CGRPR1) production in microglia, astrocyte, and meningeal cell cultures. Primary glial and meningeal cells in culture were exposed to GTN for 24 h. Messenger RNA expression was assessed using qPCR. Iron accumulation was visualized via modified Perl?s histochemistry. MMP-9 levels in cell culture supernatants were measured using …

Thalamocortical Network Interruption: A Fresh View For Migraine Symptoms, Hayrunni̇sa Bolay Belen

Turkish Journal of Medical Sciences

Migraine is a multifaceted brain disorder where multisensory disturbances are associated with headache. Yet sensory symptoms are conventionally justified by dysfunctions confined to the cerebral cortex, a perspective through the complex interplay of thalamocortical network would provide the entire picture, more pertinent to the central sensory processing. It is important to consider thalamus as a hub that integrates multiple domains via extensive connections among anatomically and functionally separate cortical areas. Accordingly, cortical spreading depression (CSD), implicated in migraine pathophysiology can be seen as a tool to disconnect thalamocortical network by functionally eliminating cerebral cortex. Hence, including thalamic reticular nucleus and …

Evaluation Of Nasal And Paranasal Findings In Cases Of Migraine, Essam A. Behairy, Khaled H. Afifi, Marwa K. Moustafa, Tarek A. Abd El-Hafez

Menoufia Medical Journal

Objective The objective of this study was to evaluate nasal and paranasal findings in cases of migraine. Background Migraine triggers are abundant, and anatomical nasal variations like septal spur, concha bullosa, and hypertrophied inferior turbinate may be considered as important trigger factors for migrainous headache by mucosal contact according to the trigeminovascular theory as a proposed mechanism for migraine. Patients and methods This was an observational cross-sectional study comparing 60 patients with migraine versus 40 normal participants with neither migraine nor nasal presentations. History was taken to define the type of migraine and its severity according to Migraine Disability Assessment …

Clinical, Neurological And Diagnostic Aspects Of Headaches In Patients With Congenital Precerebral Angiodysplasias, Kh.M. Khalimova, G.K Rakhmatullaeva, Vaitkus Antanas, N.S Rashidova

Central Asian Journal of Medicine

Objective: To study the clinical, neurological and diagnostic aspects of headaches in congenital pre-cerebral angiodysplasia. Materials and Methods: There were 213 patients with headaches under our supervision. The core of the studied cohort was migraine patients, which amounted to 179 (100%) cases, among them migraine with angiodysplasia- (MWA) was 136 (45.9%), followed by patients with migraine without angiodysplasia (MWOA) – 43 (14.5%), tension headache (TH) – 26 (8.8%), cluster headache (CH) – 8 (2.7%) patients. The study used clinical neurological, neuropsychological, neuroimaging and statistical methods. Results: Migraine can develop in people with congenital pre-cerebral angiodysplasia in 76% of cases, and …

Features Of Application Of Id-Migraine Questionnaire And Midas Scale In The Assessment Of Efficiency Of Patients With Complicated Forms Of Migraine In The Age Aspect, M. J. Sanoyeva, M.A. Gulova

Central Asian Journal of Pediatrics

The aim of the study was to optimize the criteria for diagnosis of complicated forms of migraine, using the ID-migraine questionnaire and the MIDAS scale and to assess the psycho-emotional background of patients with complicated migraine. Material and method. The paper analyzes the clinical picture and the degree of efficiency of patients suffering from some forms of complicated migraine in the comparative aspect. The analysis used the ID-migraine questionnaire and the MIDAS scale, studied the mental status, severity of patients, the nature and localization of headaches. Mental status was investigated on Hamilton's scales of depression and anxiety. The prevalence of …

Relationship Between Headache And Internet Addiction In Children, İlknur Böyükbaş Tepeci̇k, Ayşegül Neşe Çitak Kurt, Selma Tural Hesapçioğlu, Mehmet Uğurlu

Turkish Journal of Medical Sciences

Background/aim: We aimed to investigate Internet addiction in pediatric patients with migraine- and tension-type headache in this study. Materials and methods: Among our 200 subjects, 103 had migraine-type headache and 97 had tension-type headache. Results: Headache triggered by computer use was more common in the migraine-type headache group. There was no difference between the Internet addiction scale score of the two groups. The Internet addiction scale scores of the patients were found to differ depending on the aim and duration of computer use. Internet addiction was found in six (6%) patients. Internet addiction prevalence was 3.7% and 8.5% in the …

Analysis Of The Pathomechanism And Treatment Of Migraines Related To The Role Of The Neuropeptide Cgrp, Marvi S. Qureshi

The Pegasus Review: UCF Undergraduate Research Journal

Migraines are a type of headache that specifically act on only one side of the head, although about 30% of patients with migraines may experience a bilateral headache. Migraines are brain disorders that typically involve issues of sensory processing taking place in the brainstem. Possible causation has been linked to blood vessels, blood flow, and oxygen levels in the brain. Migraines can be described in three phases, all of which have a common neuropeptide known as the calcitonin gene related peptide (CGRP). CGRP increases in plasma have been linked to migraine headaches, and specific treatment plans have been tailored to …

The Built Environment And Its Patterns: A View From The Vision Sciences, A.J. Wilkins, Olivier Penacchio, Ute Leonards

SDAR* Journal of Sustainable Design & Applied Research

Abstract Visual patterns are all around us. Despite overwhelming evidence from the visual sciences that some visual patterns, in particular highly-geometric and repetitive patterns, can be aversive, patterns in our visual environment are rarely considered with regard to their impact on brain, behaviour and well-being. Yet, attempts toward developing healthier, more inclusive cities recently attracted negative headlines, for example for their use of dazzling floor patterns in public spaces that lead to discomfort, avoidance behaviours and falls, particularly in older citizens. Recent developments in analysis now allow us to measure and predict adverse effects of patterns in the real world. …

Metoclopramide Inhibits Trigeminovascular Activation:Evidence For Effective Acute Attack Treatment In Migraine, Hacer Doğanay Aydin, Doğa Vuralli, Di̇dem Tuba Akçali, Hayrunni̇sa Bolay Belen

Turkish Journal of Medical Sciences

Background/aim: Metoclopramide is an effective and commonly used medication in acute migraine treatment but an experimental evidence base is lacking. We aimed to investigate the antimigraine effect of metoclopramide in a migraine model and whether the analgesic effect of metoclopramide was likely to be D2 receptor-mediated. Materials and methods: Cortical spreading depression (CSD) was used to model migraine in adult male Wistar rats. Five CSDs were induced by pinprick. Metoclopramide (two different doses), raclopride, or 0.9% saline were administered 30 min before CSD induction. Two hours after the experiments, brain tissues were examined for c-fos activation. Results: In metoclopramide groups …

Frequency Of Cranial Autonomic Symptoms (Cas) In Migraine Patients, Sadaf Nasir, Naureen Abrar, Khalid Sher, Shahnaz Shahnaz

Pakistan Journal of Neurological Sciences (PJNS)

Of all the painful states that afflict humans, headache is undoubtedly the most frequent and common reason for seeking medical help. Headache has over 300 different types and different etiologies; migraine is one of them and continues being an under diagnosed condition in many of cases as it can be accompanied by symptoms commonly associated with other causes of facial pain. Out of 28 million people in USA who have history of headache and symptoms which mimic the typical migraine only 48% are diagnosed of migraine.

Evaluation Of The Relationship Between Migraine Disorder Andoral Comorbidities: Multicenter Randomized Clinical Trial, Cem Peşkersoy, Şule Peker, Ayşegül Kaya, Aycan Ünalp, Necmi̇ Gökay

Turkish Journal of Medical Sciences

Background/aim: Although migraine is a common disorder, there is a lack of research investigating the possible relationship between migraine and oral health. The aim of the present study was to explore the relationship between temporomandibular disorders, bruxism, dental caries, periodontal status, and migraine disorder in a multicenter, parallel, case-controlled clinical study. Materials and methods: A total of 2001 participants were divided into two groups: migraineurs (nm = 998) and nonmigraineurs (nh = 1003). International Headache Society's Second Edition of International Classification of Headache Disorders and modified Migraine Disability Assessment surveys were administered to evaluate the level of migraine; a pretreatment …

Is Oral Lornoxicam Effective In The Treatment Of Acute Migraine Attacks? : A Randomized-Controlled Study, Murat Cabalar Cabalar, Selcuk Dincer, Suleyman Ozyalcin

Pakistan Journal of Neurological Sciences (PJNS)

The aim of this study was to assess the efficacy of lornoxicam (LNX) in the treatment of acute migraine attacks. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial was conducted administering either LNX or placebo to patients who were diagnosed with migraine without aura according to the International Headache Society (the year 2004) criteria between 2010 and 2012 Results: Of 44 patients with 120 migraine attacks, 38 were female and rest were males. Mean age was 37.75 ± 9.28 years. Patients recorded using LNX in 87 migraine attacks and placebo in 33 migraine attacks, respectively. Pain intensity scores of …

Efficacy Of Memantine As A Preventive And Therapeutic Intervention For Migraine And Tension Type Headache, Sidra Sattar, Bashir Soomro

Pakistan Journal of Neurological Sciences (PJNS)

To assess the efficacy of memantine as a preventive and therapeutic intervention for migraine and tension type headache. Material and Methods: This quasi experimental (pre and post experimental) was conducted for a period of 6 months. Patients were selected from a private tertiary care hospital setup a total of 44 patients receiving memantine, were selected through purposive sampling technique. Data was analysed using SPSS version 16.0 and associations were made using Chi square test with P value of less than 0.005 was taken as significant. Results: Out of 44 patients 35 (79.9%) were female and 9 (20.5%) were male which …

Efficacy Of Memantine In Treating Patients With Migraine And Tension-Type Headache, Sameen Khalid, Bashir A Soomro, Samreen Mahmood, Aamer Abbass

Pakistan Journal of Neurological Sciences (PJNS)

Objective:
To assess the efficacy of Memantine as a preventive and therapeutic intervention for migraine and tension-type headache.

Methods:
This clinical trial was conducted over a period of 3 months. A total of 44 subjects, with diagnosed migraine and/or tension-type headache, presenting to a private neurology clinic in Karachi, Pakistan were selected through purposive sampling technique. Patients were treated with incremental doses of Memantine. Adult patients belonging to both genders were included in the study. Data was analyzed using SPSS version 16.0 and associations were made using Chi square test with p-value of less than 0.05 taken as significant. …

Migraine Prevalence, Disability, And Sociodemographic Properties In The Eastern Region Of Turkey: A Population-Based Door-To-Door Survey, Gökhan Özdemi̇r, Recep Aygül, Recep Demi̇r, Lütfi̇ Özel, Ayfer Erteki̇n, Hizir Ulvi̇

Turkish Journal of Medical Sciences

To determine the frequency of migraine in the eastern part of Turkey and its sociodemographic characteristics, impact on disability, and clinical aspects. Materials and methods: The study was conducted door-to-door in the eastern part of Turkey. Those who suffered from headaches were diagnosed with migraine as per the 2004 diagnosis criteria of the International Headache Society and its frequency was determined. Demographic data and Migraine Disability Assessment Scale (MIDAS) scores were recorded. Results: Of the individuals evaluated, 60.4% (883) suffered from headaches, of which 43.6% (637) were evaluated as nonmigraine and 16.8% (246) as migraine headaches. Migraine prevalence was detected …

Headache In Multiple Sclerosis, Mi̇ne Hayri̇ye Sorgun, Canan Yücesan, Yasemi̇n Genç

Turkish Journal of Medical Sciences

Although multiple sclerosis (MS) can cause almost any neurological symptom, headaches are considered unusual. Studies investigating the relationship between the 2 conditions have produced conflicting results. The primary aim of this study was to test whether there was a difference between patients with MS (Group 1) and the control group (Group 2, patients with psoriasis and myasthenia gravis, diseases not affecting the central nervous system) in terms of the prevalence and types of primary headache. Materials and methods: A total of 139 patients with MS and 59 patients in the control group were included. The patients underwent a complete neurological …

Brief Cognitive-Behavioral Interventions For Migraine In The Emergency Room: A Case Study, Rivka Berger, Orly Sarid

Internet Journal of Allied Health Sciences and Practice

Brief cognitive-behavioral intervention (CBI) was conducted in the emergency room (ER). The current literature on biomedical and psychological risk factors of migraine is reviewed briefly including studies demonstrating the effectiveness of CBI with such patients. The case study portrays CBI that assists a patient suffering from severe migraine attack. We cautiously proposed that CBI can provide patients with a sense of control and may offer empowerment for the personnel in the ER. An integrative approach to health care is suggested when assessing patients with migraine.

Functional Vitamin B12 Deficiency Represented By Elevated Urine Methylmalonic Acid Levels In Patients With Migraine, Osman Meti̇n İpçi̇oğlu, Ömer Özcan, Mustafa Gültepe, Hakan Tekeli̇, Mehmet Güney Şenol

Turkish Journal of Medical Sciences

Aims: Although vitamin B12 is currently used as a treatment option in patients with migraine, a possible cobalamin deficiency in those patients has not yet been investigated. In this study, we aimed to investigate cobalamin metabolism in patients with migraine. Materials and Methods: Fifty women having migraine without aura were matched with healthy controls (n=6) with the same age distribution. Fasting serum vitamin B12, folate, plasma total homocysteine (tHcy) and first morning urine methylmalonic acid (MMA) levels were determined in patient and control groups. Statistical differences in laboratory parameters between patient and control groups were analyzed by SPSS for Windows …

Migraine And Risk Of Stroke In Young Women, Theresa A. Nacey

Internet Journal of Allied Health Sciences and Practice

Purpose: To explore the relationship between migraine and incidence of stroke in young women by analyzing variables of oral contraceptive use, hypercoagulability, cardiac abnormalities, and silent brain infarcts. Method:Variables were reviewed through computerized databases and current literature examining evidence-based medicine studies specific to analyzing the incidence of strokes in women with migraines. Results: Six recent studies, four case control and two cohort studies, were identified. Research outcomes indicate that the risk of stroke is greater in women less than 35 years of age who had migraine with aura and who used oral contraceptives. Other pathophysiologic variables, which may link migraine …

Interictal Spect With Tc 99m-Hm Pao In Migrainepatients, Meral Mi̇rza, Ahmet Tutuş, Füsun Erdogan, Mustafa Kula, Ali Tomar, Güler Silov, Emel Köseoğlu

Turkish Journal of Medical Sciences

Migraine is considered to be a functional neurological disorder. For several years cerebral blood flow studies have been fueling the controversy surrounding the pathophysiology of migraine headache. Tc 99m-HM PAO SPECT brain imaging was performed during the headache-free period of 29 migraine sufferers (24 without aura, 5 with aura). The findings were compared with those of an age-and sex-matched control group of 17 people. The SPECT images revealed clear interhemispheric asymmetry in the right frontal, temporal and occipital lobes of the brain in the study group. Slight hypoperfusion was observed in patients who had interictal EEG abnormalities.

Prevalence Of Coliforms In Drinking Water And Housewife'shygiene Associated With The Contamination :A Community, Bangkok, Pipat Luksamijarulkul, Varaporn Pumsuwan

Chulalongkorn Medical Journal

No abstract provided.