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Articles 1 - 10 of 10
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Surface Chemistry And Spectroscopic Studies Of Enzymatic, Non-Enzymatic Molecules And Their Applications, Shiv K. Sharma
Surface Chemistry And Spectroscopic Studies Of Enzymatic, Non-Enzymatic Molecules And Their Applications, Shiv K. Sharma
Open Access Dissertations
The content of this thesis is an investigation into physicochemical, photophysical, and interfacial properties of β-galactosidase, a crucial enzyme, its conjugate with CDs, interaction of β-galactosidase with X-gal, and surface chemistry and spectroscopic study of toxins, Cholera toxin B (CTB) and Fumonisin B1 (FB1). The objective of the work was to understand the surface chemistry behavior of the important enzyme, conjugates and toxins in a model systems representing vaguely cell membrane environments, to prove the activity of the deposited enzyme, its conjugate, and toxins in a form of the monolayer. We also studied the effect of green LED light on …
Gas-Phase And Condensed-Phase Studies Of Small Reactive Intermediates, Christopher William Haskins
Gas-Phase And Condensed-Phase Studies Of Small Reactive Intermediates, Christopher William Haskins
Open Access Dissertations
Nitriles are an integral functional group in many chemical industries. A new methodology for the dehydration of amides to nitriles has been developed using a palladium catalyst. The reaction conditions are robust and able to tolerate a wide variety of functional groups and substrates. The substrate scope can be broken into 4 main types of substrates including: alkyl, aromatic, cinnamic, and α, β, δ, γ-unsaturated amides. Mechanistically, the amide goes through a water exchanging mechanism to generate acetamide in equal parts to the nitrile. Cyclopropanols are important precursors for the generation of beta-carbonyl radicals. In the presence of a single-electron …
A Molecular Perspective For The Understanding Of Polymer‒Drug Interactions, Laura Isabel Mosquera Giraldo
A Molecular Perspective For The Understanding Of Polymer‒Drug Interactions, Laura Isabel Mosquera Giraldo
Open Access Dissertations
Polymers are often used to stabilize amorphous drug formulations enabling the maintenance of high drug supersaturations. However, the molecular mechanism of stabilization is unclear, making the rational design of new polymers challenging. This research has focused on understanding the effectiveness of polymers to inhibit drug crystallization using experimental and computational modeling approaches. This thesis has six sections. The first section reviews the pharmaceutical significance of amorphous solid dispersions. The second section describes a study to evaluate the phase behavior of supersaturated drug solutions of telaprevir, a compound that undergoes glass-liquid phase separation when the amorphous solubility is exceeded. The third …
Microstructural Evolution During The Homogenization Heat Treatment Of 6xxx And 7xxx Aluminum Alloys, Pikee Priya
Microstructural Evolution During The Homogenization Heat Treatment Of 6xxx And 7xxx Aluminum Alloys, Pikee Priya
Open Access Dissertations
Homogenization heat treatment of as-cast billets is an important step in the processing of aluminum extrusions. Microstructural evolution during homogenization involves elimination of the eutectic morphology by spheroidisation of the interdendritic phases, minimization of the microsegregation across the grains through diffusion, dissolution of the low-melting phases, which enhances the surface finish of the extrusions, and precipitation of nano-sized dispersoids (for Cr-, Zr-, Mn-, Sc-containing alloys), which inhibit grain boundary motion to prevent recrystallization. Post-homogenization cooling reprecipitates some of the phases, changing the flow stress required for subsequent extrusion. These precipitates, however, are deleterious for the mechanical properties of the alloy …
Studies Of Novel Transition-Metal-Catalyzed Oxidative Coupling Reactions, Jinmin Miao
Studies Of Novel Transition-Metal-Catalyzed Oxidative Coupling Reactions, Jinmin Miao
Open Access Dissertations
Transition-metal-catalyzed oxidative coupling reactions are important tools for the construction of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds from simple starting materials. A series of novel and synthetically useful reactions have been developed and are herein described.
Instrumentation And Development Of A Mass Spectrometry System For The Study Of Gas-Phase Biomolecular Ion Reactions, Ziqing Lin
Open Access Dissertations
Gas-phase reactions of biomolecular ions are highly relevant to the understanding of structures and functions of the biomolecules. Mass spectrometry is a powerful tool in investigating gas-phase ion chemistry. Various mass spectrometers have been developed to explore ion/molecule reactions, ion/ion reactions, ion/photon reactions, ion/radical reactions etc., both at atmospheric pressure and in vacuum. In-vacuum reactions have an advantage of involving pre-selecting the ions for the reactions using a mass analyzer. Over the decades, a variety of mass analyzers have been employed in the research of ion chemistry. Hybrid configurations, such as quadrupole ion trap with a time-of-flight and or a …
Surface Chemistry And Spectroscopy Of Human Insulin Langmuir Monolayer, Sheba Johnson
Surface Chemistry And Spectroscopy Of Human Insulin Langmuir Monolayer, Sheba Johnson
Open Access Dissertations
The focus of this thesis can be categorized as study of two molecules, namely human insulin and carbon dots at 1) air-water interface as a Langmuir monolayer and 2) in solution. Aggregation of proteins into amyloids has been related to several diseases like Alzheimer’s, Parkinson’s and Amyloidosis. Human insulin was chosen as a model protein to study fibrillation of the proteins. Effect of carbon dots on the rate of human insulin fibrillation was examined through spectroscopic techniques and imaging. Both human insulin and carbon dots were examined at air-water interface as a Langmuir monolayer. The conformation of human insulin in …
The Anti-Epilepsy Potential And Antagonism Of The N-Methyl-D-Aspartate Receptor By Diaminodiphenyls, Kyle Robert Scully
The Anti-Epilepsy Potential And Antagonism Of The N-Methyl-D-Aspartate Receptor By Diaminodiphenyls, Kyle Robert Scully
Open Access Dissertations
Epilepsy is a disorder characterized by the occurrence of seizures, which are periods of abnormally excessive synchronous neuronal activity in the brain. Affecting over 70 million people worldwide, many of whom do not respond to pharmacotherapy, there is a need for novel anticonvulsant compound discovery. Diaminodiphenyl compounds, a class of compounds shown to present anticonvulsive effects in vivo have been purported to exert their effects on the N-methyl-D-aspartate receptor (NMDAr); an excitatory, ionotropic receptor that is a key player in the functions of the glutamatergic system. The glutamatergic system is vital in the promotion of synaptic plasticity and has …
Studies Of Molecular Encapsulation And Preparation Of Novel Cage Molecules, Yanhua Qiu
Studies Of Molecular Encapsulation And Preparation Of Novel Cage Molecules, Yanhua Qiu
Open Access Dissertations
This dissertation deals with studies of molecular encapsulation and preparation of novel molecular cages. The author begins in Chapter 1 with a short discussion of molecular encapsulation and some of the molecular hosts such as cavitands, carcerands, hemicarcerands, hexamericresorcinarene capsules and molecular cages and then presents more introductory material on a deep cavity cavitand and cucurbit[7]uril since the author’s research is majorly based on these two molecular hosts. The author is interested in the electrochemistry studies of redox-active guests and their electrochemical kinetic changes before and upon encapsulation in aqueous solution so as to mimick the behavior of redox proteins …
Contrasting View On Asphaltene And Human Cardiac Troponin I: A Surface Chemistry And Spectroscopy Perspective, Jhony Orbulescu
Contrasting View On Asphaltene And Human Cardiac Troponin I: A Surface Chemistry And Spectroscopy Perspective, Jhony Orbulescu
Open Access Dissertations
Surface chemistry has proven in the recent years that it could be used for a variety of applications. In the current work, the surface chemistry and spectroscopic techniques are used to emphasize their great potential in aggregation studies of UG8 asphaltene and the contrasting results for a surface chemistry perspective for the human cardiac troponin I. The first part of the work focuses on the influence of different spreading solvents on the aggregation of UG8 asphaltene and their comparison to the literature on the topic. It is shown that the surface chemistry approach employed in the current work has significant …