Digital Commons Network^™

Protein Residue Analysis In Archaeology: A Geological Contamination Experiment, Theresa Popp

All Graduate Theses and Dissertations, Fall 2023 to Present

Protein residue analysis has been used by archaeologists for decades to explore ancient diets and hunting behaviors based on proteins deposited on tools and artifacts, however, protein contamination of buried artifacts has been assumed but lacked formal study. Through a contamination experiment testing different geological contexts (e.g. water movement and freeze-thaw), possible routes of protein contamination within soil were identified, adversely impacting protein residue analysis conducted on buried artifacts. Protein was found to move through soil in large enough concentrations to elicit positive protein residue results on sterile artifacts that never made direct contact with the protein source used in …

Using Flipped Classroom Modules To Facilitate Higher Order Learning In Undergraduate Organic Chemistry, Lauren R. Holloway, Tabitha Miller, Bryce Da Camara, Paul M. Bogie, Briana L. Hickey, Jack Barbera, Angie L. Lopez, Multiple Additional Authors

Chemistry Faculty Publications and Presentations

In an ongoing effort to incorporate active learning and promote higher order learning outcomes in undergraduate organic chemistry, a hybrid (“flipped”) classroom structure has been used to facilitate a series of collaborative activities in the first two courses of the lower division organic chemistry sequence. An observational study of seven classes over a five-year period reveals there is a strong correlation between performance on the in-class activities and performance on the final exam across all classes; however, a significant number of students in these courses continue to struggle on both the in-class activities and final exam. The Activity Engagement Survey …

Plasma Chemistry Reference Values In Free-Living Bonelli's Eagle (Hieraaetus Fasciatus) Nestlings, Javier Balbontin, Miguel Ferrer

Journal of Raptor Research

No abstract provided.

Serum Chemistry Values For Nestling Bald Eagles (Haliaeetus Leucocephalus&Rsqb; In Florida Bay, Everglades National Park, Brian Mealey, Greta M. Parks, Carlos M. Pages, Brian A. Millsap, Orin L. Bass, Gregory D. Bossart

Journal of Raptor Research

No abstract provided.

Blood Chemistry, Cytology, And Body Condition In Adult Northern Goshawks (Accipiter Gentilis), Lauri A. Hanauska-Brown, Alfred M. Dufty Jr., Gary J. Roloff

Journal of Raptor Research

No abstract provided.

Profile: Celebrating Sustainability, Communications And Marketing

Profile (1996-)

In this issue: Zavada is First Morton Gneiss Professor; Cougar Days of Giving Event is Resounding Success; Planned Giving is Way for Alum to Give Significant Support; New at UMN Morris: Degree in Three; Cofer Named Vice Chancellor for Academic Affairs and Dean; Pandemic Challenges Led to Improved Chemistry Lab; Kapemni Program Created with NSF Grant; UMN Morris Archives Receives National Endowment for the Humanities Grant; Morris Model Wins Competition to Energize Rural Communities; UMN Morris Included in Food Justice Initiative Funding; DuHamel Receives McKnight Musician Fellowship Grant; Peters Receives JEDI Award; Brugger Named Fellow of the Geological Society of …

Chem 361-002: Environmental Chemistry Ii, Alexei Khalizov

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

A Phytochemical Analysis Of Secondary Metabolites In Eupatorium Serotinum, Elise Snow

Theses and Dissertations

Phytochemistry, a subset of Natural Products Chemistry, studies chemically derived products from natural substances. Advances in this field have important applications in medicinal research due to the distinctive and unique properties of natural compounds. All metabolites are produced from the metabolic cycle, which is a pathway that provides energy for the organism. These metabolic compounds vary greatly and are classified based on their function within the organism. Primary metabolites are abundant and contribute to organism growth, development, and maintenance of energy. Secondary metabolites are found in lesser quantity and correlate to natural defense mechanisms. For example, salicylic acid is a …

Analysis Of Students' Perceptions On The Freedom Of Learning - Independent Campus (Mbkm) Program At Chemistry Study Program Of Ma Chung University, Yuyun Yuniati, Lilis Lestari Wilujeng

Jurnal Penelitian dan Evaluasi Pendidikan

Considering that Indonesian education has gone through such a long journey from 1922 to 2022 now, it is necessary to have an educational program that is able to meet the demands of workers' needs in this era of globalization. In the end, the Directorate General of Higher Education, Research, and Technology designed an education policy system in the realm of higher education, namely "Freedom of Learning - Independent Campus", as an accurate strategy for optimizing academics in today's Indonesia. In this study, a survey was aimed at 40 undergraduate students of the Chemistry Study Program at Ma Chung University. Data …

Comparison Of Metal-Carbenoid Reactions Of Β-2-Five-Membered Heteroaryl Substituted Α,Β-Unsaturated Ketones, Kumsal Eroğlu, Olcay Anaç, Füsun Şeyma Kişkan

Turkish Journal of Chemistry

In this study, β-2-heteroaryl substituted (N-methyl 2-pyrrolyl, 2-thiophenyl, 2-furyl) α,β-unsaturated ketones were reacted with two α-diazo carbonyl compounds that had different characteristics (dimethyl diazo malonate and 1-diazo-1-phenyl-propane-2-one) in the presence of both copper and rhodium catalysts. In the case of reactions with N-methyl 2-pyrrolyl α,β-unsaturated ketones, the major product was the insertion derivative. However, in the reactions of 2-thiophenyl and 2-furyl α,β-unsaturated ketones with dimethyl diazomalonate (acceptor-acceptor disubstituted), only dihydrofuran products were formed over carbonyl ylides. When 2-thiophenyl and 2-furyl α,β-unsaturated ketones were reacted with 1-diazo-1-phenyl-propane-2-one (donor-acceptor disubstituted), 1-phenylpropane-1,2-dione was obtained under our reaction conditions.

Computational Quantum Chemistry Studies Of The Stabilities Of Radical Adducts Formed During The Oxidation Of Melatonin Derivatives, James Horne

Electronic Theses and Dissertations

Melatonin is a natural antioxidant that has been investigated for properties as a potential spin trap to identify short-lived free radicals. Computational quantum chemistry studies have been performed for the oxidation of melatonin to N¹-acetyl-N²-formyl-5-methoxykynuramine. This research focused on modification of melatonin into derivatives and analyzing the change in total molecular energy from melatonin to its oxidation product, as well as the corresponding derivatives. Each of the molecular geometries were optimized at the DFT/B3LYP/6-31G(d), DFT/B3LYP/cc-pVXZ (X = D, T), HF/6-31G(d), HF/cc-PVXZ (X = D, T), MP2/6-31G(d), and MP2/cc-PVXZ (X = D, T) levels of theory. …

Applying Density Functional Theory Simulations To Study The Charge Balancing And Structure Directing Roles Of Fluoride In Zeolite Synthesis, Tongkun Wang

Doctoral Dissertations

Zeolites represent a major cornerstone of today’s energy industry as the most-used petrochemical catalyst by weight in the world. Constituted by tetrahedra of T-atoms including Si, Al, Ge and Ti, zeolites form a huge family of nano-porous crystalline materials which also provide reliable candidates for novel, energy related applications such as efficient separations, hydrogen-purifying/storing and conversions from biomass to biofuel. However, the formation mechanism of zeolite is still not clear, as synthesis processes are complicated by requirements including structure directing agents (SDAs), hydroxide or fluoride medium, and experimental conditions like temperature. Attempts for designing new zeolite structures still fall in …

On The Origins Of Life — Modelling The Initial Stages Of Complex Coacervate Droplet Formation, Yixuan Wu

Western Libraries Undergraduate Research Awards (WLURAs)

Coacervate droplets are considered a plausible model for protocells due to their spontaneous formation and ability to compartmentalize macromolecules such as nucleic acid and peptides. Although experimental studies have observed and synthesized coacervates under different laboratory conditions, little is known about their structure. Here we present atomistic molecular dynamic simulations of the interactions between water and oppositely charged proteins that cluster together in a salt-dependent process. Observing such liquid-liquid phase separation on an atomic level would serve as a model for the initial stages of complex coacervate formation. Molecular Dynamics was used to compute diagnostics of the structure at different …

Covid-19: Implications For Audiology Practice, Madison Jane Bacca

Capstones & Scholarly Projects

Coronavirus Disease 2019, or COVID-19, emerged in Wuhan, China in December 2019 and quickly became an international public health emergency. COVID-19 was declared a worldwide pandemic in March 2020 and has spread throughout the globe (Balkhair, 2020). COVID-19 manifests in the body in a myriad of ways, ranging from no symptoms at all to critical illness or death. COVID-19 infection can have long-lasting, widespread effects on the human body, including the auditory and vestibular systems. Despite preventative efforts, COVID-19 patients have presented to audiologists with complaints of hearing loss, tinnitus, and vertigo. Audiologists need to be aware of the reported …

Chem 360-001: Environmental Chemistry, Alexei Khalizov

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

A Computational Kinetics Model To Quantify Radiation Induced Chemical Products Of Atmospheric Gas Mixtures, Patrick Ables

Dissertations

This research is focused on the development of a computational model which will calculate the effects of radiation on the chemical composition of the atmosphere. The approach utilizes the open-source chemical kinetics toolkit Cantera to model the creation of radiation-induced reactant species within irradiated air mixtures. Chemical solutions are iteratively stepped toward chemical equilibrium within a ‘constantly stirred’ (homogeneous) reactor of fixed volume. Three different radiation chemistry models are implemented in several different pulsed and continuous radiation schemes. The first model includes the mechanisms and rates of a pulse radiation model from the literature to test the validity of the …

Identification Of A Β-Arrestin-Biased Negative Allosteric Modulator For The Β2-Adrenergic Receptor, Michael Ippolito, Francesco De Pascali, Nathan Hopfinger, Konstantin E. Komolov, Daniela Laurinavichyute, Poli Adi Narayana Reddy, Leon A. Sakkal, Kyle Z. Rajkowski, Ajay P. Nayak, Justin Lee, Jordan Lee, Gaoyuan Cao, Preston S. Donover, Melvin Reichman, Stevens. An, Joseph M. Salvino, Raymond B. Penn, Roger S S. Armen, Charles P. Scott, Jeffrey L. Benovic

Department of Biochemistry and Molecular Biology Faculty Papers

Catecholamine-stimulated β2-adrenergic receptor (β2AR) signaling via the canonical Gs–adenylyl cyclase–cAMP–PKA pathway regulates numerous physiological functions, including the therapeutic effects of exogenous β-agonists in the treatment of airway disease. β2AR signaling is tightly regulated by GRKs and β-arrestins, which together promote β2AR desensitization and internalization as well as downstream signaling, often antithetical to the canonical pathway. Thus, the ability to bias β2AR signaling toward the Gs pathway while avoiding β-arrestin-mediated effects may provide a strategy to improve the functional consequences of β2AR activation. Since attempts to develop Gs-biased agonists and allosteric modulators for the β2AR have been largely unsuccessful, here we …

Protein A And Multimodal Anion-Exchange Membrane Adsorbers For Downstream Purification Of Therapeutic Biomolecules, Joshua Osuofa

All Dissertations

This dissertation explores development and characterization of membrane chromatography tools for downstream purification of therapeutic biomolecules. Convective technologies, particularly membrane chromatography, are emerging in the field of bioseparations as an alternative to resin chromatography due to their improved throughput capability. On the forefront of emerging membrane technologies are multimodal and Protein A membrane adsorbers. The overarching theme of this dissertation research was to investigate advances in these membrane chromatography tools. The primary objective was to develop and characterize novel Protein A membrane adsorbers. A secondary objective was to characterize newly commercialized Protein A and multimodal anion exchange membrane adsorbers.

Two …

The Driving Effects Of Common Atmospheric Molecules For Formation Of Clusters: The Case Of Sulfuric Acid, Formic Acid, Hydrochloric Acid, Ammonia, And Dimethylamine, Olivia M. Longsworth, Conor J. Bready, George C. Shields

Open Access Fund Publications

One of the main sources of uncertainty for understanding global warming is understanding the formation of larger secondary aerosols. The beginning stages start with the formation of prenucleation complexes from precursor monomers of acids, bases, and organic molecules. The detailed interactions responsible for prenucleation and subsequent aerosol formation are difficult to decipher experimentally. We present a computational chemistry study of the interactions between three different acid molecules and two different bases. By combining a comprehensive search routine covering many thousands of configurations at the semiempirical level with high level quantum chemical calculations of approximately 1000 clusters for every possible combination …

Pandemic Challenges Lead To Improved Chemistry Lab, Communications And Marketing

Campus News Archive

No abstract provided.

New Methods Of Selectivity Using Electrochemistry, Qiwei Jing

Arts & Sciences Electronic Theses and Dissertations

This project has been working on introducing new type of method to induce chemoselectivity into electrochemical reactions by modifying the surface of an electrode and then confining chemical reactions to the region of the reaction close to that surface. The goal is to translate the extremely high levels of site-selectivity seen in chemical reactions on a microelectrode array into a tool for preparative synthetic reactions.As a proof-of-principle experiment, Pt-anode was coated with a diblock copolymer that is known to have an affinity for pyrene groups. The electrode is then used in the oxidation of two alcohol substrates: one having the …

Scanning Probe Microscopy Studies Of Petroleum Chemistry: Substrate-Dependent Catalytic Properties Of Mos2 And Automating Scanning Probe Microscopy With Machine Learning, Steven Arias

Doctoral Dissertations

With the growth of the population, society’s energy demands are mostly reliant on petroleum products that come from the refining of crude oil. Most of these refining reactions have been developed through averaging spectroscopic techniques, but scientists do not know exactly what is happening in these processes at the nano and atomic levels. This information is crucial when designing an efficient refining process that produces petroleum products that emit fewer harmful gases when combusting. Scanning probe microscopy techniques have become a powerful tool to look into the chemical structures found in petroleum products, to understand catalytic reactions in refining processes, …

Clemson University Women Trailblazers, A. M. Alexander, J. W. Harris

Clemson University Women Trailblazers

No abstract provided.

Molecular Devices For Measuring Weak Solvophobic Interactions And The Development Of Pedagogical Tools For Organic Chemistry Students, Alexander N. Manzewitsch

Theses and Dissertations

The main topics of this dissertation are: 1) the development and discussion of a new molecular balance for measuring alkyl-alkyl interactions in a wide array of organic solvents, 2) the development of linear solvation energy relationships between solvent interaction parameters and solvent accessible surface area (SASA) in CH-arene interactions, and 3) the development of online resources for helping undergraduate students perform organic chemistry mechanisms problems well.

The solvophobic effect, that is the forced association between two solutes due to intermolecular attraction of the solvent molecules, is ubiquitous in organic chemistry and responsible for many significant phenomena thereof. However, there is …

Synthesis And Analysis Of Novel Troponoid-Based Chemical Probes, Alex Berkowitz

Dissertations, Theses, and Capstone Projects

Troponoids are a class of non-benzenoid aromatic species featuring a cycloheptatrienone ring and varying degrees of oxygenation. These scaffolds have proven ubiquitous amongst natural products, and have displayed promise as therapeutic agents against a variety of diseases. Herein, we will describe our efforts towards furthering troponoids as potential pharmaceuticals. In Chapter 1, we outline a kojic acid-derived oxidopyrylium cycloaddition/ring-opening method developed in our lab to generate ahydroxytropolones (aHTs). This route was successfully adapted to synthesize a small library of lipophilic aHTs that were proven to be effective against herpes simplex virus-1 (HSV-1) replication, while providing further insight into the mechanism …

Stratigraphy Of The Metamorphic Rocks Of Niğde Massif And New Evidence Of Triassic Rifting Of The Inner Tauride Ocean (Central Anatolia, Türkiye), Mustafa Kemal Özkan, Metin Beyazpi̇ri̇nç, Ali Ekber Akçay, Muhamed Çoban, Osman Candan, Osman Ersin Koralay, Meftun Kerem Sönmez, Halil Yusufoğlu

Bulletin of the Mineral Research and Exploration

Metamorphites of Niğde Massif, which form the basis of the study area covering the Niğde vicinity in Central Anatolia, are composed of Late Devonian Gümüşler, Carboniferous-early Permian Kaleboynu late Permian Kızıldağ formation and unconformable Triassic-Late Cretaceous cover units from bottom to the top, which are separated from each other with unconformities. The Triassic succession (Söğütlüdere formation) of phyllite-marble-schist alternations with common amphibolite levels is first distinguished in this study, unconformably overlies the Paleozoic succession. Thick homogeneous marbles of Jurassic-Cretaceous period, is defined by quartzite at the bottom representing the unconformity at the base, is defined as the Kırtepe formation. The …

Production Of Rare-Earth Oxides From Eskişehir-Beylikova Complex Ores, Haydar Güneş, Hüseyin Eren Obuz, Hasan Akçay, Çiğdem Kara, Ayşe Erdem

Bulletin of the Mineral Research and Exploration

In this study, the production technology of barite, fluorite, rare-earth elements, and thorium-bearing rare-earth oxides from the Eskişehir-Beylikova were investigated, and the processes that can be used in the production of thorium-free mixed rare earth oxides were tested. The applied processes are roasting, leaching, solvent extraction and precipitation methods, respectively. After all studies, the optimum roasting temperature and roasting duration are determined as 600 °C and 1 hour. In the extraction stage, the highest leaching efficiency is achieved with 5 M HCl, 1-hour leaching duration, 1/3 solid/liquid ratio and 35 °C leaching temperature. While methyl tri C8-C10 ammonium chloride (Adogen …

Paleoecological Investigation Of The Miocene (23.03-5.33 Mya) Rodents (Mammalia: Rodentia) In Anatolia, Hasan Vural, Şakir Önder Özkurt

Bulletin of the Mineral Research and Exploration

Anatolia’s geographical location as a land bridge between Europe, Asia, and Africa, makes it an important passage for mammal migrations, with a rich fossil potential. However, detailed scientific studies on the Neogene paleogeography of Anatolia are scarce. Rodentia is among the major mammal groups generally adapting to different habitat types and rapidly evolving with the changing geography. Investigating this group provides data to increase the accuracy of ecological analyses. We selected Rodentia fossils from the Miocene excavation sites with published papers, and examined specimens of 14 families from 106 localities. Cricetidae, Muridae, Gliridae, and Sciuridae were found to be most …

Magnetic Anisotropy Of A Sub-Ophiolitic Metamorphic Sole (Mersin Ophiolite, Türkiye), Buğra Çavdar, Antony Morris, Mark Anderson, Luca Menegon, Osman Parlak

Bulletin of the Mineral Research and Exploration

The Mersin ophiolite of southern Turkey is a well-exposed, Late Cretaceous, Neo-Tethyan suprasubduction
zone ophiolite. It is underlain by metamorphic sole rocks inferred to have formed at the top of a down-going plate during subduction. These have a well-developed foliation and lineation observable in the field (defined by the preferred orientations of hornblende and plagioclase crystals). Here we present the first magnetic fabric data reported from the Mersin ophiolite with such settings. Anisotropy of low field magnetic susceptibility ellipsoids in sampled amphibolites have clustered, NW-plunging minimum principal axes representing poles to a SE-dipping magnetic foliation that aligns with the macroscopic …

The Importance Of Confocal Raman Spectroscopy And Mineral Chemistry Studies In The Magma Crystallization Processes: Strandja Intrusives, Nw Türkiye, Ezgi Ulusoy, Yusuf Kağan Kadioğlu

Bulletin of the Mineral Research and Exploration

The Strandja Massif cropping out in NW Turkey is cut by Late Cretaceous intrusives. These are called Strandja Intrusives and they are felsic and mafic coeval intrusives. Felsic intrusives consist of granite, granodiorite, quartz monzonite and syenite, while mafic intrusives consist of diorite and gabbro composition. Main composition of felsic intrusives consists of quartz, alkali feldspar, plagioclase, biotite, amphibole ±pyroxene mineral association, while main composition of mafic ones consists of plagioclase, biotite, amphibole ±pyroxene ±olivine mineral association. Amphiboles hydrated double-chain mineral of the Strandja Intrusives observed in all rocks used as an index mineral in this study to understand the …