Antitrypanosomal Activities And Cytotoxicity Of Some Novel Imido-Substituted 1,4-Naphthoquinone Derivatives, Franklin Ampy
Nov 2011
Antitrypanosomal Activities And Cytotoxicity Of Some Novel Imido-Substituted 1,4-Naphthoquinone Derivatives, Franklin Ampy
Franklin Ampy
The antitrypanosomal activities, cytotoxicity, and selectivity indices of eleven imido-substituted 1,4-naphthoquinone derivatives and nifurtimox have been studied. Compared to nifurtimox (IC(50) = 10.67 μM), all the imido-naphthoquinone analogs (IMDNQ1-IMDNQ11) are more potent on Trypanosoma cruzi with IC50 values ranging from 0.7 μM to 6.1 μM (p < 0.05). Studies of the cytotoxic activities of these compounds on a Balb/C 3T3 mouse fibroblast cell line revealed that four of these compounds, IMDNQ1, IMDNQ2, IMDNQ3, and IMDNQ10 displayed selectivity indices of 60.25, 53.97, 31.83, and 275.3, respectively, rendering them significantly (p < 0.05) more selective in inhibiting the parasite growth than nifurtimox …
Ethnic Identity And Type 2 Diabetes Health Attitudes In Americans Of African Ancestry, Jelena Brezo, Charmaine D. Royal, Franklin Ampy, Verle Headings
Dec 2005
Ethnic Identity And Type 2 Diabetes Health Attitudes In Americans Of African Ancestry, Jelena Brezo, Charmaine D. Royal, Franklin Ampy, Verle Headings
Franklin Ampy
Background: Exploring the role of ethnic identity may be a good starting point toward a better understanding of health attitudes in different communities. This knowledge would be most useful in addressing diseases that cause significant burden and for which known prevention and morbidity-reducing strategies are effective.
Objective: The main objective was to investigate possible associations between measures of ethnic identity and health attitudes toward type 2 diabetes mellitus by using a questionnaire-based measure.
Ethiopian Soils Harbor Natural Populations Of Rhizobia That Form Symbioses With Common Bean (Phaseolus Vulgaris L.), Serawit Kassa, Desta Beyene, Franklin Ampy, Amha Asseffa, Tadesse Gebremedhin, Peter Van Berkum
Jan 2004
Ethiopian Soils Harbor Natural Populations Of Rhizobia That Form Symbioses With Common Bean (Phaseolus Vulgaris L.), Serawit Kassa, Desta Beyene, Franklin Ampy, Amha Asseffa, Tadesse Gebremedhin, Peter Van Berkum
Franklin Ampy
The diversity and taxonomic relationships of 83 bean-nodulating rhizobia indigenous to Ethiopian soils were characterized by PCR-RFLP of the internally transcribed spacer (ITS) region between the 16S and 23S rRNA genes, 16S rRNA gene sequence analysis, multilocus enzyme electrophoresis (MLEE), and amplified fragment-length polymorphism. The isolates fell into 13 distinct genotypes according to PCR-RFLP analysis of the ITS region. Based on MLEE, the majority of these genotypes (70%) was genetically related to the type strain of Rhizobium leguminosarum. However, from analysis of their 16S rRNA genes, the majority was placed with Rhizobium etli. Transfer and recombination of the 16S rRNA …
Drosophila Alcohol Dehydrogenase: Developmental Studies On Cryptic Variant Lines, Gurbachan Miglani, Franklin Ampy
Sep 1981
Drosophila Alcohol Dehydrogenase: Developmental Studies On Cryptic Variant Lines, Gurbachan Miglani, Franklin Ampy
Franklin Ampy
Thirty-five cryptic variant lines were used to examine the mechanisms involved in genetic modulation of alcohol metabolism in Drosophila. Late third-instar larval, preemergence pupal, and adult stages cultured at 18 and 28 C were examined. Spectrophotometric analyses for native alcohol dehydrogenase (ADH) activity and residual ADH activity after treatment with guanidine hydrochloride and heat were performed. Differential response of cryptic variants to treatment with the denaturants during development suggested that this variation may have an adaptive significance.
Changes In Native Alcohol Dehydrogenase Activity Of Drosophila Upon Treatment With Guanidine Hydrochloride, Urea And Heat, Gurbachan Miglani, Franklin Ampy
Aug 1981
Changes In Native Alcohol Dehydrogenase Activity Of Drosophila Upon Treatment With Guanidine Hydrochloride, Urea And Heat, Gurbachan Miglani, Franklin Ampy
Franklin Ampy
Fifty-two isochromosomal lines ofDrosophila melanogaster were examined for the existence of additional genetic variations in ADH activity subsequent to treatment With guanidine hydrochloride, urea and heat. A wealth of hidden variation was discovered among and within the Mexican populations of the insect after treatment with the denaturants.
Statistical Analysis Of Cryptic Variation In Drosophila Alcohol Dehydrogenase, Gurbachan Miglani, Franklin Ampy
Aug 1981
Statistical Analysis Of Cryptic Variation In Drosophila Alcohol Dehydrogenase, Gurbachan Miglani, Franklin Ampy
Franklin Ampy
Statistical analysis indicated that mean alcohol dehydrogenase (ADH) activity levels within ADH1 and ADH11 isochromosomal lines varied significantly among the Mexican populations ofDrosophila melanogaster used. Also as indicated by coefficient of variation values for ADH activity, the relative amount of genetic variation differed among and within the ADH1 and ADH11 strains examined. The quantitative nature of the differences in ADH activity supported the concept of the additive gene action of the alcohol dehydrogenase (Adh) locus. The manner in which our isochromosomal lines were constructed suggested that genes regulating ADH activity inD. melanogaster were located on the second chromosomes.
