Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network

Open Access. Powered by Scholars. Published by Universities.®

Faculty Publications

2020

Discipline
Institution
Keyword
File Type

Articles 151 - 180 of 1654

Full-Text Articles in Entire DC Network

Facets Of Christian Leadership, Petr Cincala Nov 2020

Facets Of Christian Leadership, Petr Cincala

Faculty Publications

No abstract provided.


Neutrino Interaction Classification With A Convolutional Neural Network In The Dune Far Detector, B. Abi, R. Acciarri, M. A. Acero, G. Adamov, D. Adams, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano, V. Aushev, D. Autiero, F. Azfar Nov 2020

Neutrino Interaction Classification With A Convolutional Neural Network In The Dune Far Detector, B. Abi, R. Acciarri, M. A. Acero, G. Adamov, D. Adams, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano, V. Aushev, D. Autiero, F. Azfar

Faculty Publications

The Deep Underground Neutrino Experiment is a next-generation neutrino oscillation experiment that aims to measure CP-violation in the neutrino sector as part of a wider physics program. A deep learning approach based on a convolutional neural network has been developed to provide highly efficient and pure selections of electron neutrino and muon neutrino charged-current interactions. The electron neutrino (antineutrino) selection efficiency peaks at 90% (94%) and exceeds 85% (90%) for reconstructed neutrino energies between 2-5 GeV. The muon neutrino (antineutrino) event selection is found to have a maximum efficiency of 96% (97%) and exceeds 90% (95%) efficiency for reconstructed neutrino …


Neutrino Interaction Classification With A Convolutional Neural Network In The Dune Far Detector, B. Abi, R. Acciarri, M. A. Acero, G. Adamov, D. Adams, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J.. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernadez, Roberto Petti, Et. Al. Nov 2020

Neutrino Interaction Classification With A Convolutional Neural Network In The Dune Far Detector, B. Abi, R. Acciarri, M. A. Acero, G. Adamov, D. Adams, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J.. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernadez, Roberto Petti, Et. Al.

Faculty Publications

The Deep Underground Neutrino Experiment is a next-generation neutrino oscillation experiment that aims to measure CP-violation in the neutrino sector as part of a wider physics program. A deep learning approach based on a convolutional neural network has been developed to provide highly efficient and pure selections of electron neutrino and muon neutrino charged-current interactions. The electron neutrino (antineutrino) selection efficiency peaks at 90% (94%) and exceeds 85% (90%) for reconstructed neutrino energies between 2–5 GeV. The muon neutrino (antineutrino) event selection is found to have a maximum efficiency of 96% (97%) and exceeds 90% (95%) efficiency for reconstructed …


Civilian Pepper Spray For Self Defense: Understanding User Perception And Impact Of Design On User Performance, David Strybel, Anil R. Kumar Nov 2020

Civilian Pepper Spray For Self Defense: Understanding User Perception And Impact Of Design On User Performance, David Strybel, Anil R. Kumar

Faculty Publications

Pepper spray is widely used in the US, and is marketed as an effective self-defense device. While pepper spray can be useful in deterring an attacker, many pepper spray owners do not have any experience using it. There is a dearth of published studies that focus on civilian pepper-spray use, not to mention first time pepper-spray users. A study to analyze pepper-spray designs with first-time users, to see how the design, specifically the safety mechanism, affects response time and overall performance would be helpful. The study was conducted in 2 parts – a survey to understand user perception, and a …


Fungal Community Structure And Function Shifts With Atmospheric Nitrogen Deposition, Jessica A. M. Moore, Mark A. Anthony, Gregory J. Pec, Lidia K. Trocha, Artur Trzebny, Kevin M. Geyer, Linda T. A. Van Diepen, Serita D. Frey Nov 2020

Fungal Community Structure And Function Shifts With Atmospheric Nitrogen Deposition, Jessica A. M. Moore, Mark A. Anthony, Gregory J. Pec, Lidia K. Trocha, Artur Trzebny, Kevin M. Geyer, Linda T. A. Van Diepen, Serita D. Frey

Faculty Publications

Fungal decomposition of soil organic matter depends on soil nitrogen (N) availability. This ecosystem process is being jeopardized by changes in N inputs that have resulted from a tripling of atmospheric N deposition in the last century. Soil fungi are impacted by atmospheric N deposition due to higher N availability, as soils are acidified, or as micronutrients become increasingly limiting. Fungal communities that persist with chronic N deposition may be enriched with traits that enable them to tolerate environmental stress, which may trade-off with traits enabling organic matter decomposition. We hypothesized that fungal communities would respond to N deposition by …


¿Existe Un Español Antillano?, Orlando Alba Nov 2020

¿Existe Un Español Antillano?, Orlando Alba

Faculty Publications

El objetivo fundamental de esta exposición consiste en demostrar, con el apoyo de más de 80 audio-clips y desde una perspectiva sociolingüística, que, a pesar de las conocidas semejanzas existentes en su modo de hablar, Cuba, República Dominicana y Puerto Rico mantienen su propia identidad lingüística.

Cada isla manifiesta su propia idiosincrasia lingüística, tanto en el terreno objetivo, de la actuación, como en el subjetivo, de la percepción. En el plano objetivo, existen estructuras sintácticas y unidades léxicas que actúan como elementos distintivos. Asimismo, son notables las discrepancias fonéticas cuantitativas y cualitativas entre los dialectos de cada país. A esto …


«Astrología Y Genealogía De Poder En La Vida Es Sueño De Calderón De La Barca Y La Comedia Anónima El Vaticinio Cumplido: La Estrella De Inglaterra.», Carmela V. Mattza Nov 2020

«Astrología Y Genealogía De Poder En La Vida Es Sueño De Calderón De La Barca Y La Comedia Anónima El Vaticinio Cumplido: La Estrella De Inglaterra.», Carmela V. Mattza

Faculty Publications

¿En qué medida la relación entre astrología y genealogía de autoridad y poder presente en la comedia calderoniana puede servirnos para estudiar otras comedias áureas de temas parecidos? ¿Hasta qué punto la presencia de esos discursos genealógicos puede echar luz sobre el uso de la comedia como propaganda? A manera de respuesta, en la presente comunicación presentada en el congreso de la Asociación Internacional de Siglo de Oro celebrado en Madrid en 2017, me propongo estudiar y comparar la función del eclipse en La vida es sueño, la comedia paradigmática de Calderón, con la que aparece en la comedia …


Selective One-Dimensional 13C-13C Spin-Diffusion Solid-State Nuclear Magnetic Resonance Methods To Probe Spatial Arrangements In Biopolymers Including Plant Cell Walls, Peptides, And Spider Silk, Bennett Addison, Dillan Stengel, Vivek S. Bharadwaj, Renee M. Happs, Crissa Doeppke, Tuo Wang, Yannick J. Bomble, Gregory P. Holland, Anne E. Harman-Ware Nov 2020

Selective One-Dimensional 13C-13C Spin-Diffusion Solid-State Nuclear Magnetic Resonance Methods To Probe Spatial Arrangements In Biopolymers Including Plant Cell Walls, Peptides, And Spider Silk, Bennett Addison, Dillan Stengel, Vivek S. Bharadwaj, Renee M. Happs, Crissa Doeppke, Tuo Wang, Yannick J. Bomble, Gregory P. Holland, Anne E. Harman-Ware

Faculty Publications

© 2020 American Chemical Society. All rights reserved. Two-dimensional (2D) and 3D through-space 13C-13C homonuclear spin-diffusion techniques are powerful solid-state nuclear magnetic resonance (NMR) tools for extracting structural information from 13C-enriched biomolecules, but necessarily long acquisition times restrict their applications. In this work, we explore the broad utility and underutilized power of a chemical shift-selective one-dimensional (1D) version of a 2D 13C-13C spin-diffusion solid-state NMR technique. The method, which is called 1D dipolar-assisted rotational resonance (DARR) difference, is applied to a variety of biomaterials including lignocellulosic plant cell walls, microcrystalline peptide fMLF, and black widow dragline spider silk. 1D 13C-13C …


Social Contact, Time Alone, And Parental Subjective Well-Being: A Focus On Stay-At-Home Fathers Using The American Time Use Survey, Erin K. Holmes, Jocelyn Wikle, Clare R. Thomas, Mckell A. Jorgensen, Braquel R. Egginton Nov 2020

Social Contact, Time Alone, And Parental Subjective Well-Being: A Focus On Stay-At-Home Fathers Using The American Time Use Survey, Erin K. Holmes, Jocelyn Wikle, Clare R. Thomas, Mckell A. Jorgensen, Braquel R. Egginton

Faculty Publications

Stay-at-home fathers (SAHFs) face negative stereotypes and social stigma, which may be linked to negative feelings during social contact. In this study, we compare SAHFs' social contact and time alone to that of stay-at-home mothers and parents of other work/caregiving statuses. In addition, we analyze SAHFs' subjective well-being when with their children, spouse, noon spouse adults, and when alone to more accurately capture the positive and negative valences of their experiences. Using individual-level time-use diaries form the American Time Use Survey (N = 35, 959), a nationally representative sample, we find that compared to fathers working full time, SAHFs …


Classification Of Planetary Craters Using Outline-Based Morphometrics, Thomas J. Slezak, Jani Radebaugh, Eric H. Christiansen, Mark C. Belk Nov 2020

Classification Of Planetary Craters Using Outline-Based Morphometrics, Thomas J. Slezak, Jani Radebaugh, Eric H. Christiansen, Mark C. Belk

Faculty Publications

The morphologies of craters on planetary surfaces reveal clues about the geologic mechanisms by which they originate and subsequently evolve, as well as the materials and physical variables inherent to the environment in which they formed. We carried out a quantitative multivariate analysis of shape descriptors derived from the outlines of craters formed by volcanic processes on Mars, Io, and Earth and by impact cratering on the Moon using elliptic Fourier analysis (EFA) and the Zahn-Roskies (Z-R) shape function. Canonical variate analysis (CVA) was used to construct a statistical model of differences between the crater groups to classify …


Prevalence Of Eating Disorder Risk And Body Image Dissatisfaction Among Rotc Cadets, Allison Smith, Dawn Emerson, Zachary Winkelmann, Devin Potter, Toni Torres-Mcgehee Nov 2020

Prevalence Of Eating Disorder Risk And Body Image Dissatisfaction Among Rotc Cadets, Allison Smith, Dawn Emerson, Zachary Winkelmann, Devin Potter, Toni Torres-Mcgehee

Faculty Publications

Injury risk is multifactorial including non-modifiable and modifiable factors such as nutrition and mental health. The purpose of this study was to estimate eating disorder risk and body image (BI) dissatisfaction among Reserve Officers Training Corps (ROTC) cadets. A total of 102 (male: = 75, female: = 27; age: 20 ± 2 years) ROTC cadets self-reported height, current and ideal weight, and completed the Eating Attitudes Test-26 (EAT-26) and self-perceived BI current and perceived sex-specific figural stimuli. The overall eating disorder risk for ROTC cadets was 32.4%. No significant differences were found when comparing sex, ethnicity, or military branch. Overall …


Uncertain Regional Urbanism In Venezuela. Government, Infrastructure And Environment, Fabio Capra-Ribeiro Nov 2020

Uncertain Regional Urbanism In Venezuela. Government, Infrastructure And Environment, Fabio Capra-Ribeiro

Faculty Publications

Uncertain Regional Urbanism in Venezuela explores the changes cities face when they become metropolises, forming expanding regions which create both potential and problems within settlements. To do so, it focuses on three metropolitan areas located in Venezuela’s Center-North region: Caracas, Maracay and Valencia, designated as "Camava."

Considering three core topics, government and territorial administration, infrastructure and environment, as well as looking at the reciprocal impact, this book describes and analyzes the determinant variables that characterize the phenomenon of regional urbanization in this area and in the wider Global South. It includes documentary research, semi-structured interviews and Delphi methodology, involving a …


Plant Invasion Impacts On Fungal Community Structure And Function Depend On Soil Warming And Nitrogen Enrichment, Mark A. Anthony, K. A. Stinson, Jessica A. M. Moore, Serita D. Frey Nov 2020

Plant Invasion Impacts On Fungal Community Structure And Function Depend On Soil Warming And Nitrogen Enrichment, Mark A. Anthony, K. A. Stinson, Jessica A. M. Moore, Serita D. Frey

Faculty Publications

The impacts of invasive species on biodiversity may be mitigated or exacerbated by abiotic environmental changes. Invasive plants can restructure soil fungal communities with important implications for native biodiversity and nutrient cycling, yet fungal responses to invasion may depend on numerous anthropogenic stressors. In this study, we experimentally invaded a long-term soil warming and simulated nitrogen deposition experiment with the widespread invasive plant Alliaria petiolata (garlic mustard) and tested the responses of soil fungal communities to invasion, abiotic factors, and their interaction. We focused on the phytotoxic garlic mustard because it suppresses native mycorrhizae across forests of North America. We …


Evaluating Research Centers In Minority Institutions: Framework, Metrics, Best Practices, And Challenges, Angela Sy, Traci Hayes, Kelly Laurila, Carlamarie Noboa, Robbert J. Langwerden, Michelle M. Hospital, Doris A. Andújar-Pérez, Lakesha Stevenson, Suzanne M.Randolph Cunningham, Latrice Rollins, Hala Madanat, Tanya Penn, Shiva Mehravaran Nov 2020

Evaluating Research Centers In Minority Institutions: Framework, Metrics, Best Practices, And Challenges, Angela Sy, Traci Hayes, Kelly Laurila, Carlamarie Noboa, Robbert J. Langwerden, Michelle M. Hospital, Doris A. Andújar-Pérez, Lakesha Stevenson, Suzanne M.Randolph Cunningham, Latrice Rollins, Hala Madanat, Tanya Penn, Shiva Mehravaran

Faculty Publications

The NIH-funded Research Centers in Minority Institutions (RCMI) program is currently funding 18 academic institutions to strengthen the research environment and contribution to health disparities research. The purpose of this multiphase mixed-methods study was to establish a uniform evaluation framework for demonstrating the collective success of this research consortium. Methods included discussions of aims and logic models at the RCMI Evaluators’ Workshop, a literature review to inform an evaluation conceptual framework, and a case study survey to obtain evaluation-related information and metrics. Ten RCMIs participated in the workshop and 14 submitted responses to the survey. The resultant RCMI Evaluation Conceptual …


Parsing The Impact Of Alice And The Peg, Colleen Chien, Nicholas Halkowski, Maria He, Rodney Swartz Nov 2020

Parsing The Impact Of Alice And The Peg, Colleen Chien, Nicholas Halkowski, Maria He, Rodney Swartz

Faculty Publications

Almost two years have passed since the USPTO issued its January 2019 Patent Eligibility Guidance (PEG), itself a response to the Supreme Court’s Alice decision, and what many perceived as its destabilizing impact on the certainty of patent prosecutions. Leveraging new data releases, we report on trends in prosecution following the USPTO’s PEG and the Guidance on 112, finding 1) a decline in subject matter rejections and stabilization of subject matter appeals, 2) no discernable increase in 112 rejections, 3) no evidence that small entities were being left behind in Alice-impacted art units by forum shopping by large entities, …


Discrete Bethe-Sommerfeld Conjecture For Triangular, Square, And Hexagonal Lattices, Jake Fillman, Rui Han Nov 2020

Discrete Bethe-Sommerfeld Conjecture For Triangular, Square, And Hexagonal Lattices, Jake Fillman, Rui Han

Faculty Publications

We prove the discrete Bethe-Sommerfeld conjecture on the graphene lattice, on its dual lattice (the triangular lattice), and on the extended Harper lattice. For each of these lattice geometries, we analyze the behavior of small periodic potentials. In particular, we provide sharp bounds on the number of gaps that may perturbatively open, we describe sharp arithmetic criteria on the periods that ensure that no gaps open, and we characterize those energies at which gaps may open in the perturbative regime. In all three cases, we provide examples that open the maximal number of gaps and estimate the scaling behavior of …


The Lyophilized Aqueous Leaf Extract Of Moringa Oleifera Blunts Streptozocin-Induced Diabetes In Rats Through Upregulation Of Glut 4 Signaling Pathway And Anti-Oxidant Effect, Adeolu Alex Adedapo, Iyanuoluwa Omolola Ogunmiluyi, Olufunke Olubunmi Falayi, Blessing Seun Ogunpolu, Ademola Adetokunbo Oyagbemi, Abayomi Orishadipe, Temidayo Olutayo Omobowale, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju Nov 2020

The Lyophilized Aqueous Leaf Extract Of Moringa Oleifera Blunts Streptozocin-Induced Diabetes In Rats Through Upregulation Of Glut 4 Signaling Pathway And Anti-Oxidant Effect, Adeolu Alex Adedapo, Iyanuoluwa Omolola Ogunmiluyi, Olufunke Olubunmi Falayi, Blessing Seun Ogunpolu, Ademola Adetokunbo Oyagbemi, Abayomi Orishadipe, Temidayo Olutayo Omobowale, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju

Faculty Publications

The anti-diabetic property of aqueous leaf extract of Moringa oleifera was performed in streptozocin-induced diabetic rats using serum chemistry, histology and immunochemical parameters as indices of diabetes. The blood glucose level of the diabetic untreated group continues to increase while that of the treated group after 21 days decreased. While the animals in the diabetic untreated group experienced increase in the levels of markers of organ damage when compared to the control group (P values < 0.0001). ALT increased from 61.83±1.5 to 96.1±22.4, AST was 225.1±26.6 from 172.6±13.9, ALP 13.5±0.006 to 13.6±0.002, UREA 1.0±0.08 to 3.0±0.4, their reduction was observed in the extract-treated groups. ALT reduced from 96.1±22.4 to 73.70±9.7; AST from 225.1±26.6 to 184.4±18.2; ALP from 13.6±0.002 to 13.6±0.01; UREA from 3.0±0.4 to 2.0±0.4. Treatment with the extract significantly reduced markers of oxidative stress in the kidney [hydrogen peroxide (898.8±6.26 to 688.0±13.7), malondialdehyde (640±0.1 to 600±0.2) and protein carbonyl (548.4±1.5 to 458.1±1.6)]; heart [hydrogen peroxide (389.4±1.8 to 358.2±1.5), malondialdehyde (264.0±0.5 to 122.0±0.3), protein carbonyl (196.8±0.5 to 162.7±3.5)]; and liver [hydrogen peroxide (119.36±3.2 to 103.94±10.7), malondialdehyde (236.0±0.4 to 73.0±0.2), protein carbonyl (269.3±1.0 to 174.2±1.1) respectively. The levels of antioxidants were reduced in the diabetic untreated group but there was increase in the Moringa treated group. Glucose transporter 4 (GLUT 4) was down regulated in the diabetic untreated group while it was well expressed in the treated groups. The histology of pancreas and liver showed varied levels of infiltration of inflammatory cells, congestion and necrotic lesions, but these were mild in the treated groups. The result shows that the extract does have an anti-diabetic effect with the decrease in the levels of blood glucose and markers of oxidative stress as well as increase in the amount of antioxidants in the treated group when compared to the diabetic untreated group. More importantly, the extract caused upregulation of GLUT 4, which is relevant in reversing insulin resistance in the same manner as pioglitazone, the standard antidiabetic agent used in this study.


Bioanalytical Assay Development And Validation For The Pharmacokinetic Study Of Gmc1, A Novel Fkbp52 Co-Chaperone Inhibitor For Castration Resistant Prostate Cancer, Oscar Ekpenyong, Candace Cooper, Jing Ma, Naihsuan C. Guy, Ashley N. Payan, Fuqiang Ban, Artem Cherkasov, Marc B. Cox, Dong Liang, Huan Xie Nov 2020

Bioanalytical Assay Development And Validation For The Pharmacokinetic Study Of Gmc1, A Novel Fkbp52 Co-Chaperone Inhibitor For Castration Resistant Prostate Cancer, Oscar Ekpenyong, Candace Cooper, Jing Ma, Naihsuan C. Guy, Ashley N. Payan, Fuqiang Ban, Artem Cherkasov, Marc B. Cox, Dong Liang, Huan Xie

Faculty Publications

Background: GMC1 (2-(1H-benzimidazol-2-ylsulfanyl)-N-[(Z)-(4-methoxyphenyl) methylideneamino] acetamide) effectively inhibits androgen receptor function by binding directly to FKBP52. This is a novel mechanism for the treatment of castration resistant prostate cancer (CRPC). Methods: an LC-MS/MS method was developed and validated to quantify GMC1 in plasma and urine from pharmacokinetics studies in rats. An ultra-high-performance liquid chromatography (UHPLC) system equipped with a Waters XTerra MS C18 column was used for chromatographic separation by gradient elution with 0.1% (v/v) formic acid in water and methanol. A Sciex 4000 QTRAP® mass spectrometer was used for analysis by multiple reaction monitoring (MRM) in positive mode; the specific …


Deficiency Of Splicing Factor 1 (Sf1) Reduces Intestinal Polyp Incidence In ApcMin/+ Mice, Jyotsna D. Godavarthi, Shahrazad Polk, Lisa Nunez, Amruthesh Shivachar, Nancy L. Glenn Griesinger, Angabin Matin Nov 2020

Deficiency Of Splicing Factor 1 (Sf1) Reduces Intestinal Polyp Incidence In ApcMin/+ Mice, Jyotsna D. Godavarthi, Shahrazad Polk, Lisa Nunez, Amruthesh Shivachar, Nancy L. Glenn Griesinger, Angabin Matin

Faculty Publications

Background: Splicing factor 1 (SF1) is a conserved alternative splicing factor expressed in many different mammalian cell types. The genetically modified Sf1+/− (or Sf1β-geo/+ ) mice express reduced levels of SF1 protein in mouse tissues, including in cells of the intestines. Mutational inactivation of human adenomatous polyposis coli (APC) gene deregulates the Wnt signaling pathway and is a frequent genetic event in colon cancers. Mice with a point mutation in the Apc gene (ApcMin/+ ) also develop numerous intestinal polyps at a young age. Our aim was to determine the effect of reduced SF1 levels on polyp development due to …


Trends And Associated Characteristics For Chagas Disease Among Women Of Reproductive Age In The United States, 2002 To 2017, Chioma Ikedionwu, Deepa Dongarwar, Manvir Kaur, Lisa Nunez, Annabella Awazi, Jere' Mallet, Ka Shena Kennedy, Michelle Cano, Chinwe Dike, Jessica Okwudi, Justice Stewart, David Igwegbe, Flora G. Estes, Kiara K. Spooner, Jason L. Salemi, Hamisu M. Salihu, Omonike A. Olaleye Nov 2020

Trends And Associated Characteristics For Chagas Disease Among Women Of Reproductive Age In The United States, 2002 To 2017, Chioma Ikedionwu, Deepa Dongarwar, Manvir Kaur, Lisa Nunez, Annabella Awazi, Jere' Mallet, Ka Shena Kennedy, Michelle Cano, Chinwe Dike, Jessica Okwudi, Justice Stewart, David Igwegbe, Flora G. Estes, Kiara K. Spooner, Jason L. Salemi, Hamisu M. Salihu, Omonike A. Olaleye

Faculty Publications

Background: American trypanosomiasis, commonly referred to as Chagas disease, is caused by a single cell protozoan known as Trypanosoma cruzi (T. cruzi). Although those affected are mainly in Latin America, Chagas has been detected in the United States (US), Canada and in many European countries due to migration. Few studies have explored the epidemiology of Chagas within the US or changes in disease burden over the past decade. The objective of this study was to explore the trends and associated characteristics for Chagas disease among hospitalized women of reproductive age in the US. Methods: We analyzed admissions data including socio-demographic …


Histone Deacetylase Inhibitors As Multitarget-Directed Epi-Drugs In Blocking Pi3k Oncogenic Signaling: A Polypharmacology Approach, Kasturi Ranganna, Chelliah Selvam, Amruthesh Shivachar, Zivar Yousefipour Nov 2020

Histone Deacetylase Inhibitors As Multitarget-Directed Epi-Drugs In Blocking Pi3k Oncogenic Signaling: A Polypharmacology Approach, Kasturi Ranganna, Chelliah Selvam, Amruthesh Shivachar, Zivar Yousefipour

Faculty Publications

Genetic mutations and aberrant epigenetic alterations are the triggers for carcinogenesis. The emergence of the drugs targeting epigenetic aberrations has provided a better outlook for cancer treatment. Histone deacetylases (HDACs) are epigenetic modifiers playing critical roles in numerous key biological functions. Inappropriate expression of HDACs and dysregulation of PI3K signaling pathway are common aberrations observed in human diseases, particularly in cancers. Histone deacetylase inhibitors (HDACIs) are a class of epigenetic small-molecular therapeutics exhibiting promising applications in the treatment of hematological and solid malignancies, and in non-neoplastic diseases. Although HDACIs as single agents exhibit synergy by inhibiting HDAC and the PI3K …


Temporal Trends Of Gestational Malaria In The United States, Justin Alexander, Deepa Dongarwar, Emmanuella Oduguwa, Larianna Varnado, Adesola Adenote, Jade Bailey, Chibueze Ezeudu, Patrice Nelson, Alexis Shavers, Abimbola Telufusi, Kiara K. Spooner, Jason L. Salemi, Omonike A. Olaleye, Hamisu M. Salihu Nov 2020

Temporal Trends Of Gestational Malaria In The United States, Justin Alexander, Deepa Dongarwar, Emmanuella Oduguwa, Larianna Varnado, Adesola Adenote, Jade Bailey, Chibueze Ezeudu, Patrice Nelson, Alexis Shavers, Abimbola Telufusi, Kiara K. Spooner, Jason L. Salemi, Omonike A. Olaleye, Hamisu M. Salihu

Faculty Publications

Background: Although regarded as rare in the United States (US), increased global traffic and importation of malaria from endemic countries may lead to a rise in gestational malaria in the US. Methods: This multi-year retrospective study analyzed trends in diagnosed cases of gestational malaria from 2002 to 2017 using joinpoint regression models. We also assessed the association between gestational malaria and selected maternal-fetal adverse outcomes. Results: Mothers diagnosed with gestational malaria tended to be older, and the majority of diagnosed cases (52.9%) were among Non-Hispanic (NH) Blacks. Diagnosed cases of gestational malaria are on the rise in the US. Mothers …


Analysis Of Factors Contributing To The Severity Of Large Truck Crashes, Jinhong Li, Jinli Liu, Pengfei Liu, Yi Qi Nov 2020

Analysis Of Factors Contributing To The Severity Of Large Truck Crashes, Jinhong Li, Jinli Liu, Pengfei Liu, Yi Qi

Faculty Publications

Crashes that involved large trucks often result in immense human, economic, and social losses. To prevent and mitigate severe large truck crashes, factors contributing to the severity of these crashes need to be identified before appropriate countermeasures can be explored. In this research, we applied three tree‐based machine learning (ML) techniques, i.e., random forest (RF), gradient boost decision tree (GBDT), and adaptive boosting (AdaBoost), to analyze the factors contributing to the severity of large truck crashes. Besides, a mixed logit model was developed as a baseline model to compare with the factors identified by the ML models. The analysis was …


The Remand Power And The Supreme Court's Role, Aaron-Andrew P. Bruhl Nov 2020

The Remand Power And The Supreme Court's Role, Aaron-Andrew P. Bruhl

Faculty Publications

"Reversed and remanded." Or "vacated and remanded." These familiar words, often found at the end of an appellate decision, emphasize that an appellate court's conclusion that the lower court erred generally does not end the litigation. The power to remand for further proceedings rather than wrap up a case is useful for appellate courts because they may lack the institutional competence to bring the case to a final resolution (as when new factual findings are necessary) or lack an interest in the fact-specific work of applying a newly announced legal standard to the particular circumstances at hand. The modern Supreme …


Locked, Loaded, And Ready For School: The Association Of Safety Concerns With Weapon-Carrying Behavior Among Adolescents In The United States, Soumyadeep Mukherjee, Ziyad Ben Taleb, Philip Baiden Nov 2020

Locked, Loaded, And Ready For School: The Association Of Safety Concerns With Weapon-Carrying Behavior Among Adolescents In The United States, Soumyadeep Mukherjee, Ziyad Ben Taleb, Philip Baiden

Faculty Publications

There is limited, if any, prior research exploring the potential link between adolescents’ safety concerns and their predisposition to possess weapons has been limited. This study aimed to examine the relationship between high school students’ perceived lack of safety and their weapons carrying behavior in a multiyear nationally representative sample of high school students. Information on self-reported weapons carrying in past month and gun carrying in past year, perceived lack of safety at school or during commute, being bullied and/or threatened, involvement in physical fights, and demographic characteristics were retrieved from Youth Risk Behavior Surveillance Survey data for 1991-2017. Generalized …


Extensions Of Real Bounded Symmetric Domains, Gestur Ólafsson, Robert J. Stanton Nov 2020

Extensions Of Real Bounded Symmetric Domains, Gestur Ólafsson, Robert J. Stanton

Faculty Publications

For a real bounded symmetric domain, G/K, we construct various natural enlargements to which several aspects of harmonic analysis on G/K and G have extensions. Our starting point is the realization of G/K as a totally real submanifold in a bounded domain Gh/Kh. We describe the boundary orbits and relate them to the boundary orbits of Gh/Kh. We relate the crown and the split-holomorphic crown of G/K to the crown Ξh of Gh/Kh. We identify an extension of a representation of K to a larger group Lc and use that to extend sections of vector bundles over the Borel compactification …


Microbiological, Physicochemical, And Immunological Analysis Of A Commercial Cashew Nut-Based Yogurt, Christopher P. Mattison, Kayanush Aryana, Kristen Clermont, Eric Prestenburg, Steven W. Lloyd, Casey .. Grimm, Richard L. Wasserman Nov 2020

Microbiological, Physicochemical, And Immunological Analysis Of A Commercial Cashew Nut-Based Yogurt, Christopher P. Mattison, Kayanush Aryana, Kristen Clermont, Eric Prestenburg, Steven W. Lloyd, Casey .. Grimm, Richard L. Wasserman

Faculty Publications

Nut-based milks and yogurts are gaining popularity, but may not offer the same benefits as dairy yogurts to consumers. Cashew nuts often cause severe allergic reactions, and cashew nut allergens are stable to several types of processing. To compare its characteristics to dairy yogurt and characterize the effects of fermentation on the Ana o 1-3 cashew nut allergens, a commercial yogurt made from cashew nuts (Cashewgurt) was evaluated for microbiological, physiochemical, and immunological properties. Average counts for lactobacilli and Streptococcus thermophilus were greater than 10 million colony forming units per milliliter, indicating the capacity to provide a health benefit. Cashewgurt …


Scale(S) Matter: Deconstructing An Area Of Endemism For Middle American Freshwater Fishes, Diego J. Elías, Caleb D. Mcmahan, Wilfredo A. Matamoros, Adan E. Gómez-González, Kyle R. Piller, Prosanta Chakrabarty Nov 2020

Scale(S) Matter: Deconstructing An Area Of Endemism For Middle American Freshwater Fishes, Diego J. Elías, Caleb D. Mcmahan, Wilfredo A. Matamoros, Adan E. Gómez-González, Kyle R. Piller, Prosanta Chakrabarty

Faculty Publications

© 2020 John Wiley & Sons Ltd Aim: The processes that generate biodiversity occur at finer scales than are often studied, particularly in freshwater systems of the northern Neotropics. We investigate whether fine-scale biogeographic patterns are present within the larger Grijalva–Usumacinta Area of Endemism (AoE) —a region in Middle America where nearly 60% of freshwater fishes are endemic—and if present-day river basins are single historical units. Location: Northern Central America and southern Mexico. Taxon: Freshwater fishes (e.g., Cichlidae, Poeciliidae, Ostariophysi). Methods: We used fine-scale distributional data for freshwater fishes in northern Middle America (based on museum records and fieldwork) and …


Speciation-By-Depth On Coral Reefs: Sympatric Divergence With Gene Flow Or Cryptic Transient Isolation?, Carlos Prada, Michael E. Hellberg Nov 2020

Speciation-By-Depth On Coral Reefs: Sympatric Divergence With Gene Flow Or Cryptic Transient Isolation?, Carlos Prada, Michael E. Hellberg

Faculty Publications

The distributions of many sister species in the sea overlap geographically but are partitioned along depth gradients. The genetic changes leading to depth segregation may evolve in geographic isolation as a prerequisite to coexistence or may emerge during primary divergence leading to new species. These alternatives can now be distinguished via the power endowed by the thousands of scorable loci provided by second-generation sequence data. Here, we revisit the case of two depth-segregated, genetically isolated ecotypes of the nominal Caribbean candelabrum coral Eunicea flexuosa. Previous analyses based on a handful of markers could not distinguish between models of genetic exchange …


Community Context And Dispersal Stochasticity Drive Variation In Spatial Spread, Tad Dallas, Brett Melbourne, Alan Hastings Nov 2020

Community Context And Dispersal Stochasticity Drive Variation In Spatial Spread, Tad Dallas, Brett Melbourne, Alan Hastings

Faculty Publications

© 2020 British Ecological Society Dispersal is a key process in shaping species spatial distributions. Species interactions and variation in dispersal probabilities may jointly influence species spatial dynamics. However, many studies examine dispersal as a neutral process, independent of community context or intraspecific variation in dispersal behaviour. Here, we use controlled, replicated communities of two Tribolium species (T. castaneum and T. confusum) to examine how intraspecific variation in dispersal behaviour and community context influence dispersal dynamics in simple experimental landscapes composed of homogeneous habitat patches. We found considerable individual-level variation in dispersal probability that was unrelated to body size variation. …