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The Modeling And Control Of Freeze Dryers, Martin James Millman

Doctoral Dissertations

"Two models of the freeze drying process were constructed and used to study various operational policies in order to determine the policy that would provide the shortest drying times.

The sublimation model which accounts only for the removal of frozen water, is found to predict shorter times for the free water removal phase than the sorption-sublimation model which properly accounts for the removal of frozen and bound water.

This study shows that the policy which produces the shortest free water removal phase, also produces the shortest overall drying time. This policy, predicted by both models, holds the chamber pressure at …