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Measuring Inflammation In The Entire Myocardium In A Canine Model Of Myocardial Infarction With Hybrid Pet/Mri, Benjamin Wilk
Measuring Inflammation In The Entire Myocardium In A Canine Model Of Myocardial Infarction With Hybrid Pet/Mri, Benjamin Wilk
Electronic Thesis and Dissertation Repository
Background: After myocardial infarction (MI), fibrosis and an ongoing dysregulated inflammatory response are associated with adverse cardiac remodeling. Fluorodeoxyglucose (FDG) positron emission tomography (PET) is sensitive to inflammation provided suppression protocols are implemented to restrict the uptake of glucose in myocytes. Magnetic resonance imaging can be used to determine extracellular volume, a surrogate measure of fibrosis. In some cases, patients present with markedly reduced flow in the setting of a large infarct, i.e. microvascular obstruction, restricting the delivery of FDG and contrast agents. To overcome this problem, a constant infusion was explored as an alternative to the clinical standard bolus …
Ischemic Stroke Thrombus Characterization Through Quantitative Magnetic Resonance Imaging, Spencer D. Christiansen
Ischemic Stroke Thrombus Characterization Through Quantitative Magnetic Resonance Imaging, Spencer D. Christiansen
Electronic Thesis and Dissertation Repository
Stroke is a pervasive, devastating disease and remains one of the most challenging conditions to treat. In particular, risk of recurrence is dramatically heightened after a primary stroke and requires urgent preventative therapy to effectively mitigate. However, the appropriate preventative therapy depends on the underlying source of the stroke, known as etiology, which is challenging to determine promptly. Current diagnostic tests for determining etiology underwhelm in both sensitivity and specificity, and in as much as 35% of cases etiology is never determined. In ischemic stroke, the composition of the occluding thrombus, specifically its red blood cell (RBC) content, has been …